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For people with uncontrolled asthma on inhaled steroids, is it better to increase the dose or add a long-acting muscarinic antagonist? | Cochrane

We don't yet know whether adding LAMA to ICS is better or worse than increasing the dose of ICS. It is important that future studies include a treatment group for people given a double dose of ICS, because this is an option for doctors treating people with asthma.  
cochrane.org
almost 6 years ago
Www.bmj
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Self management for a man with asthma

A 35 year old man with a history of asthma attended the practice asthma clinic a few weeks after an acute exacerbation. He was a non-smoker who had asthma as a child but “grew out of” the more troublesome symptoms in his teens. He regards his asthma as well controlled, although his computer record suggested that he has had six short acting bronchodilator inhalers in the past year. He is more troubled by hay fever, which he manages with antihistamines that he buys from the pharmacy. He has a sedentary lifestyle so avoids exercise induced symptoms. He has a repeat prescription for an inhaled steroid (which he takes “when he needs it”) and carries a salbutamol inhaler with him in case he experiences any chest tightness. Despite annual invitations to the asthma clinic he last attended six years ago.  
feeds.bmj.com
almost 6 years ago
Www.bmj
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Antibiotics in fetal and early life and subsequent childhood asthma: nationwide population based study with sibling analysis

Objective To investigate the association between exposure to antibiotics in fetal and early life and asthma in childhood, with adjustment for confounding factors.  
feeds.bmj.com
almost 6 years ago
Static.www.bmj
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Adenotonsillectomy reduces acute asthma exacerbations in children, study shows

Children who undergo adenotonsillectomy have a 30% reduction in acute exacerbations of asthma in the year after their surgery compared with the year before, a large US study has shown.1  
feeds.bmj.com
almost 6 years ago
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Mepolizumab as opposed to placebo for asthma | Cochrane

Asthma is an inflammatory lung condition characterised by the narrowing of the airways, breathlessness, a tight chest and reduced quality of life. By the year 2025, there may be up to 400 million people with asthma worldwide. Mepolizumab is one treatment that may help to reduce the symptoms.  
cochrane.org
almost 6 years ago
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Severe Asthma Exacerbation

This week's case is written by Dr. Andrew Hall. He is an Assistant Professor in the Department of Emergency Medicine at Queen’s University where he is a Simulation-based Resuscitation Rounds Instructor and runs the Simulation-based OSCE Assessment Program for EM residents. He's also one of the advisory board members here at EMSimCases. Why it Matters…  
emsimcases.com
almost 6 years ago
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Management of Mild to Moderate Asthma Exacerbations - R.E.B.E.L. EM - Emergency Medicine Blog

This post accompanies the REBEL Cast episode on The Crashing Asthmatic from June 2015 and about management of the mild to moderate asthma exacerbation  
rebelem.com
almost 6 years ago
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Does adding a long-acting muscarinic antagonist (LAMA) to an inhaled steroid help people with uncontrolled asthma more than an inhaled steroid alone? | Cochrane

Main point: People with poorly controlled asthma are less likely to have an asthma attack needing treatment with oral steroids if they take a LAMA on top of their inhaled steroid. LAMA also improve lung function compared with inhaled steroids alone, but their benefit is uncertain for hospital admissions, serious adverse events, quality of life and asthma control.  
cochrane.org
almost 6 years ago
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Sublingual immunotherapy for asthma | Cochrane

We assessed the evidence on the use of sublingual immunotherapy (SLIT) for people with asthma compared with placebo or with normal treatment for asthma. We focused on whether SLIT is a good treatment for asthma and whether it is safe.  
cochrane.org
almost 6 years ago
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Should macrolides be used for chronic asthma? | Cochrane

Main point: Studies do not show that macrolides are better than placebo for most outcomes. There may be a benefit on lung function but it depends on how this is measured. The evidence was very low quality so we can't rule out the possibility of other benefits or harms.  
cochrane.org
almost 6 years ago
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Reslizumab Works Best in Late-Onset Eosinophilic Asthma

A new analysis of phase 3 data shows that the anti-interleukin-5 antibody is more effective in patients older than 40 years.  
medscape.com
over 5 years ago
Is 150930 gut microbiomes bacteria 800x600
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Gut Bacteria Disparities Offer Clues to Asthma Etiology

Children at the highest risk for asthma had a lower abundance of four bacteria in their gut in their first 3 months of life, a critical period that may offer future opportunities for prevention.  
medscape.com
over 5 years ago
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H3K18 Acetylation in Epithelial Cells of Asthmatic Subjects

What's the interaction between histone modifications and gene regulation in asthma?  
medscape.com
over 5 years ago