Atherosclerosis

This animation shows a simplified version of the macrophage's role in the initiation of atherosclerosis. In an atherosclerotic-prone blood vessel, macrophages invade the subendothelial space. Oxidised Low-Density Lipoproteins (oxLDL) present within the vessel wall will bind to scavenger receptors on the macrophage's surface, such as CD36. This will activate the macrophage, and it will phagocytose the oxLDL. As this process continues, the macrophage increases in size and forms a Foam Cell, which is too large to pass between the endothelial cells back into the lumen. Therefore, the foam cells remain in the subendothelial space and are the main cells present within an atherosclerotic plaque. *** Done for Student Selected Component (SSC), University of Aberdeen. Year 2. 2011. Made in Adobe Photoshop CS2 and Adobe Imageready.  

This animation shows a simplified version of the macrophage's role in the initiation of atherosclerosis. In an atherosclerotic-prone blood vessel, macrophages invade the subendothelial space. Oxidised Low-Density Lipoproteins (oxLDL) present within the vessel wall will bind to scavenger receptors on the macrophage's surface, such as CD36. This will activate the macrophage, and it will phagocytose the oxLDL. As this process continues, the macrophage increases in size and forms a Foam Cell, which is too large to pass between the endothelial cells back into the lumen. Therefore, the foam cells remain in the subendothelial space and are the main cells present within an atherosclerotic plaque. *** Done for Student Selected Component (SSC), University of Aberdeen. Year 2. 2011. Made in Adobe Photoshop CS2 and Adobe Imageready.  

Covers the pathogenesis myocardial ischemia, risk factors (eg: atherosclerosis), the spectrum of acute coronary syndrome, reliable investigation and treatment of choice.  

Atherosclerosis is the condition in which an artery wall thickens as the result of a build-up of fatty materials such as cholesterol.It most commonly becomes seriously symptomatic when interfering with the coronary circulation supplying the heart or cerebral circulation supplying the brain, and is considered the most important underlying cause of strokes, heart attacks, and most cardiovascular diseases, in general. A stent is a man-made 'tube' inserted into a natural passage/conduit in the body to prevent, or counteract, a disease-induced, localized flow constriction. Stents are used to counter narrowing of arteries due to plaque deposition and hardening.  

A concise tutorial about the clinical aspects of peripheral arterial disease affecting the lower limb, from history to management and prognosis. Included in this multimedia tutorial is a definition of claudication, an explanation and audio example of a normal arterial doppler waveform, and a visual run-through of bypass grafts.  

Outline and pathogenesis.  

 

Peripheral vascular disease (PVD) is due to atherosclerosis of arteries in the limbs. The level of arterial occlusion present is proportional to the symptoms. The pathogenesis and risk factors are the same as for coronary artery disease (CAD), and include: Hypertension Dyslipidaemia High LDL and low LDL levels Diabetes Obesity FH of arterial disease Smoking Age Male gender   Epidemiology  

 

Atherosclerosis of a coronary artery Shown is a typical eccentric atherosclerotic plaque. A central necrotic core shows dystrophic calcification. Note the fibrous cap and that the media is thinned...  

Abdominal aneurysm of aorta secondary to atherosclerosis.  

This animation reviews the physiological effects of Angiotensin II in the cardiovascular system that contribute to the development of atherosclerosis.  

In this video lecture, Professor Fink reviews the pathophysiology of Cardiovascular Disease (describing relationships between atherosclerosis, increased risk...  

Learn about atherosclerosis and why it's bad for the blood vessels  

Learn about atherosclerosis and why it's bad for the blood vessels  

The story of the formation of an atheroma 1 four stages.  

UPDATE 07/2014: A newer version of this animation is now available! Watch it here: https://www.youtube.com/watch?v=wbShOXhO6p8 This 3d medical animation illu...  

This animation reviews the physiological effects of Angiotensin II in the cardiovascular system that contribute to the development of atherosclerosis.  

1. Early menopausal hormone therapy shows no effect on atherosclerosis progressionEarly initiation of menopausal hormone therapy (MHT) improves some markers of...  

Nanometer-sized 'drones' that deliver a special type of healing molecule to fat deposits in arteries could become a new way to prevent heart attacks caused by atherosclerosis, according to a...