Researchers at UT Southwestern Medical Center have uncovered how the body's inflammatory response can alter how estrogen promotes the growth of breast cancer cells.
almost 6 years ago
The Michaelis-Menten Model Accounts for the Kinetic Properties of Many Enzymes - Biochemistry - NCBI Bookshelf
The primary function of enzymes is to enhance rates of reactions so that they are compatible with the needs of the organism. To understand how enzymes function, we need a kinetic description of their activity. For many enzymes, the rate of catalysis V0, which is defined as the number of moles of product formed per second, varies with the substrate concentration [S] in a manner shown in Figure 8.11. The rate of catalysis rises linearly as substrate concentration increases and then begins to level off and approach a maximum at higher substrate concentrations. Before we can accurately interpret this graph, we need to understand how it is generated. Consider an enzyme that catalyzes the S to P by the following pathway: Figure 8.11Michaelis-Menten KineticsA plot of the reaction velocity (V0) as a function of the substrate concentration [S] for an enzyme that obeys Michaelis-Menten kinetics shows that the maximal velocity (Vmax) is approached asymptotically. The Michaelis constant (KM) is the substrate concentration yielding a velocity of Vmax/2.
over 5 years ago
The Cori Cycle is responsible for removing excess Lactic acid or Lactate from the muscle. It is then uptaken by the Liver where it is converted back into Pyruvate, then into Glucose again. This video explains how!
about 5 years ago