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BiomedicalResearch

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National Institutes of Health (NIH)

Official website of the National Institutes of Health (NIH). NIH is one of the world's foremost medical research centers. An agency of the U.S. Department of Health and Human Services, the NIH is the Federal focal point for health and medical research. The NIH website offers health information for the public, scientists, researchers, medical professionals, patients, educators, and students. The Site has extensive information on funding and training opportunities, clinical trials, health news and links to the many Institutes and Centers that make-up the NIH.  
nih.gov
over 3 years ago
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EQUATOR Network - Wikipedia, the free encyclopedia

The EQUATOR (Enhancing the QUAlity and Transparency Of health Research)[1] Network is an international initiative aimed at promoting transparent and accurate reporting of health research studies to enhance the value and reliability of medical research literature.[2] The EQUATOR Network was established with the goals of raising awareness of the importance of good reporting of research, assisting in the development, dissemination and implementation of reporting guidelines for different types of study designs, monitoring the status of the quality of reporting of research studies in the health sciences literature, and conducting research relating to issues that impact the quality of reporting of health research studies.[3] The Network acts as an “umbrella” organisation, bringing together developers of reporting guidelines, medical journal editors and peer reviewers, research funding bodies, and other key stakeholders with a mutual interest in improving the quality of research publications and research itself.  
en.wikipedia.org
over 3 years ago
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Epidemiology and Reporting Characteristics of Systematic Reviews of Biomedical Research: A Cross-Sectional Study

In a cross-sectional manuscript analysis, David Moher and colleagues score the prevalence, quality of conduct and completeness of reporting among systematic reviews published across medical disciplines in 2014.  
journals.plos.org
over 3 years ago
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PLOS Medicine: A Peer-Reviewed Open-Access Journal

PLOS Medicine publishes research and commentary of general interest with clear implications for patient care, public policy or clinical research agendas.  
journals.plos.org
over 3 years ago
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The Perils of Reliance on Industry Funding of Medical Research

As the incremental benefits of new therapies diminish, perhaps the next big innovation in cardiovascular medicine is basic lifestyle changes. But how will we know if no one funds that research, argues Dr Mandrola.  
medscape.com
over 3 years ago
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Harvard relaxes COI rules for clinical researchers

Harvard Medical School has relaxed its conflicts of interest (COI) rules for faculty members who conduct clinical research, more than doubling the amount they can receive from the companies whose products they are investigating.  
feeds.bmj.com
over 3 years ago
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Pursuit of truly independent data monitoring committees in research

Independent data monitoring committees aim to protect the interests of trial participants, and their duty of care towards participants should not be affected by conflicting interests. Many agencies overseeing medical research have drawn up guidance on the topic. The International Conference on Harmonisation states: “All staff involved in the conduct of the trial should remain blind to the results of [interim] analyses, because of the possibility that their attitudes to the trial will be modified and cause changes in the characteristics of patients to be recruited or biases in treatment comparisons.”1 2  
feeds.bmj.com
over 3 years ago
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Clinical Research, Controversies Highlight Thoracic Meeting

Controversy about e-cigarettes, debates on topics in chronic obstructive pulmonary disease, and a report on Ebola will all be featured at the American Thoracic Society 2016 International Conference.  
medscape.com
over 3 years ago
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SGEM#149: Share Decision Making for Pain Control in Older ED Patients

Guest Skeptic: Dr. Tim Platts-Mills. Tim is an Assistant Professor of Emergency Medicine; Director, Clinical Research; Co-Director of Geriatric Emergency Medicine at the University of North Carolina. His career goal is to improve the quality of emergency care for older adults through research, research mentorship, and support of the larger community of geriatric emergency medicine researchers. Tim’s research group is currently developing a protocol to screen for elder abuse in the emergency department. He also serves as a decision editor in geriatrics for Annals of Emergency Medicine.  
thesgem.com
almost 4 years ago
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'Failing Fast' and Moving Forward in Clinical Cancer Research

The goal of clinical research in cancer should not be to conduct trials the fastest or achieve the largest number of positive trials at all costs, argues Dr Jack West.  
medscape.com
almost 4 years ago
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Regression discontinuity designs in healthcare research

Clinical decisions are often driven by decision rules premised around specific thresholds. Specific laboratory measurements, dates, or policy eligibility criteria create cut-offs at which people become eligible for certain treatments or health services. The regression discontinuity design is a statistical approach that utilizes threshold based decision making to derive compelling causal estimates of different interventions. In this review, we argue that regression discontinuity is underutilized in healthcare research despite the ubiquity of threshold based decision making as well as the design’s simplicity and transparency. Moreover, regression discontinuity provides evidence of “real world” therapeutic and policy effects, circumventing a major limitation of randomized controlled trials. We discuss the implementation, strengths, and weaknesses of regression discontinuity and review several examples from clinical medicine, public health, and health policy. We conclude by discussing the wide array of open research questions for which regression discontinuity stands to provide meaningful insights to clinicians and policymakers  
feeds.bmj.com
almost 4 years ago
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Rare Diseases and Translational Research at NIH

Dr Marshall Summar interviews Dr Petra Kauffman about the National Institutes of Health's initiatives to bring more new treatments to more patients more quickly.  
medscape.com
almost 4 years ago
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Brazil Finds Zika in Saliva, Urine; Expert Warns Against Kissing

Scientists identified the Zika virus in the saliva and urine of two infected patients, a top Brazilian biomedical research institution said on Friday, prompting its president to urge pregnant women not to kiss strangers just as local carnival celebrations begin.  
medscape.com
almost 4 years ago
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Anti-VEGF Therapy for Persistent Diabetic Macular Edema

In patients with persistent diabetic macular edema (DME), there may be long-term benefits to be gained from continuing with anti-vascular endothelial growth factor (anti-VEGF) therapy, according to a post hoc analysis of a Diabetic Retinopathy Clinical Research (DRCR) Network trial.  
medscape.com
almost 4 years ago
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The Alphabet Soup of Clinical Trial Acronyms

Cardiologist Christopher Labos takes a humorous look at the evolution and explosion in the use of catchy acronyms for naming clinical research trials.  
medscape.com
almost 4 years ago
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Are we finally getting serious about fixing science?

Chris Chambers: Biomedical research has faced criticism for being unreliable, but today’s report from the Academy of Medical Sciences might change all that  
theguardian.com
almost 4 years ago
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Will PCORnet Save US Clinical Research?

Drs Harrington and Hernandez discuss the inefficiencies of the US clinical trial system and their involvement in the National Patient-Centered Clinical Research Network's first trial on aspirin dose.  
medscape.com
almost 4 years ago
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Five minutes with . . . Wellcome Trust’s Nicola Perrin

The UK biomedical research charity the Wellcome Trust has appointed an independent panel to review requests to access data from industry sponsored clinical trials. The BMJ asked the trust’s head of policy, Nicola Perrin, to explain why  
feeds.bmj.com
about 4 years ago
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Mary Lasker - Wikipedia, the free encyclopedia

Mary Woodard Lasker (November 30, 1900 – February 21, 1994) was an American health activist and philanthropist. She worked to raise funds for medical research, and founded the Lasker Foundation.  
en.wikipedia.org
about 4 years ago
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Lasker Award - Wikipedia, the free encyclopedia

The Lasker Awards have been awarded annually since 1945 to living persons who have made major contributions to medical science or who have performed public service on behalf of medicine. They are administered by the Lasker Foundation, founded by Albert Lasker and his wife Mary Woodard Lasker (later a medical research activist). The awards are sometimes referred to as "America's Nobels". Eighty-six Lasker laureates have received the Nobel Prize, including 32 in the last two decades.[1][2] Claire Pomeroy is the current President of the Foundation.  
en.wikipedia.org
about 4 years ago