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Is adrenaline safe and effective as a treatment for out of hospital cardiac arrest?

Adrenaline (epinephrine) has been an integral component of advanced resuscitation algorithms since the early 1960s. Initial guidelines for the treatment of cardiac arrest recommended the use of intracardiac adrenaline (0.5 mg) or high dose intravenous adrenaline (10 mg), repeating with larger doses if required.1 The mechanism of action for adrenaline in cardiac arrest is attributed to stimulation of α2 receptors in vascular smooth muscle, causing vasoconstriction. This increases aortic diastolic pressure, which in turn leads to increased coronary perfusion pressures, which improves short term survival. Experimental studies, however, suggest that adrenaline impairs cerebral macrovascular2 and microvascular blood flow,3 4 increases ventricular arrhythmias, and increases myocardial dysfunction after return of spontaneous circulation.5 This creates the paradox of better short term survival but at the potential cost of worse long term outcomes.  
bmj.com
over 5 years ago
Static.www.bmj
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19

Influence of blood prostate specific antigen levels at age 60 on benefits and harms of prostate cancer screening: population based cohort study

Objective To determine the relative risks of prostate cancer incidence, metastasis, and mortality associated with screening by serum prostate specific antigen (PSA) levels at age 60.  
bmj.com
over 5 years ago
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241

ABG & VBG - Arterial and Venous Blood Gas - interpreting results

 
almostadoctor.com - free medical student revision notes
over 5 years ago
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68

LFTs - Liver Function Tests

Almost every patient admitted to hospital will have their liver function tested, along with a full blood count, urea and electrolytes, glucose, and probably CRP. A typical set of LFTS will include: Bilirubin - can show pre-hepatic, intra-hepatic and post-hepatic causes of jaundice. A patient won't necessarily be visibly jaundiced if bilirubin is raised, especially if the bilirubin is not grossly elevated.  
almostadoctor.co.uk
over 5 years ago
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11

Robot Draws Blood

This robot system can find a vein and place a needle at least as well as a human can. Veebot, a start-up in Mountain View, Calif., is hoping to automate draw...  
YouTube
over 5 years ago
Static.www.bmj
1
6

Interpreting raised serum prolactin results

A 29 year old woman working in a solicitor’s office presented with secondary amenorrhoea and was found to have a serum prolactin concentration of 2940 mIU/L (upper reference limit <600) and thyroid stimulating hormone (TSH) concentration of 5.2 mIU/L (reference range 0.27-4.2 mIU/L). She had a history of depression and had previously been treated for anxiety and hyperthyroidism. There was no history of acne or hirsutism, and, until eight months before presentation, her periods had been regular. Her body mass index (BMI) was 18 compared with 19.8 the previous year.  
bmj.com
over 5 years ago
Static.www.bmj
1
7

Interpreting raised serum prolactin results

A 29 year old woman working in a solicitor’s office presented with secondary amenorrhoea and was found to have a serum prolactin concentration of 2940 mIU/L (upper reference limit <600) and thyroid stimulating hormone (TSH) concentration of 5.2 mIU/L (reference range 0.27-4.2 mIU/L). She had a history of depression and had previously been treated for anxiety and hyperthyroidism. There was no history of acne or hirsutism, and, until eight months before presentation, her periods had been regular. Her body mass index (BMI) was 18 compared with 19.8 the previous year.  
bmj.com
over 5 years ago
Static.www.bmj
1
14

Interpreting raised serum prolactin results

A 29 year old woman working in a solicitor’s office presented with secondary amenorrhoea and was found to have a serum prolactin concentration of 2940 mIU/L (upper reference limit <600) and thyroid stimulating hormone (TSH) concentration of 5.2 mIU/L (reference range 0.27-4.2 mIU/L). She had a history of depression and had previously been treated for anxiety and hyperthyroidism. There was no history of acne or hirsutism, and, until eight months before presentation, her periods had been regular. Her body mass index (BMI) was 18 compared with 19.8 the previous year.  
bmj.com
over 5 years ago
Static.www.bmj
1
6

Interpreting raised serum prolactin results

A 29 year old woman working in a solicitor’s office presented with secondary amenorrhoea and was found to have a serum prolactin concentration of 2940 mIU/L (upper reference limit <600) and thyroid stimulating hormone (TSH) concentration of 5.2 mIU/L (reference range 0.27-4.2 mIU/L). She had a history of depression and had previously been treated for anxiety and hyperthyroidism. There was no history of acne or hirsutism, and, until eight months before presentation, her periods had been regular. Her body mass index (BMI) was 18 compared with 19.8 the previous year.  
bmj.com
over 5 years ago
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22

Internal medicine on Instagram: “Hemoglobin H disease: Peripheral blood smear from a patient with hemoglobin H disease and an intact spleen. The smear shows target cells…”

“Hemoglobin H disease: Peripheral blood smear from a patient with hemoglobin H disease and an intact spleen. The smear shows target cells (blue arrows),…”  
Instagram
over 5 years ago
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47

Internal medicine on Instagram: “Peripheral blood smear from a patient with multiple myeloma shows red blood cell rouleaux (arrows), giving the appearance of stacked coins.”

“Peripheral blood smear from a patient with multiple myeloma shows red blood cell rouleaux (arrows), giving the appearance of stacked coins.”  
Instagram
over 5 years ago
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Internal medicine on Instagram: “Peripheral blood smear from a patient with a microangiopathic hemolytic anemia with marked red cell fragmentation. The smear shows multiple…”

“Peripheral blood smear from a patient with a microangiopathic hemolytic anemia with marked red cell fragmentation. The smear shows multiple helmet cells…”  
Instagram
over 5 years ago
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23

External jugular vein - Wikipedia, the free encyclopedia

The external jugular vein receives the greater part of the blood from the exterior of the cranium and the deep parts of the face, being formed by the junction of the posterior division of the retromandibular vein with the posterior auricular vein.  
en.wikipedia.org
about 5 years ago
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WHO | What we know about transmission of the Ebola virus among humans

The Ebola virus is transmitted among humans through close and direct physical contact with infected bodily fluids, the most infectious being blood, faeces and vomit.  
who.int
about 5 years ago
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Freeze-dried Blood! - The Naked Scientists

Naked Scientists - 9th Jun 2014 - Freeze-dried Blood!  
thenakedscientists.com
about 5 years ago
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20

Arterial blood gas interpretation in 5 min

The basics of analysing an ABG in 5 min  
YouTube
about 5 years ago
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Bilirubin 1 - Bilirubin Pathway

http://www.handwrittentutorials.com - This tutorial is the first of the Bilirubin series. It explains the Bilirubin Pathway from the destruction of Red Blood...  
YouTube
about 5 years ago
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19

Peripheral Resistance and Blood Flow

http://www.interactive-biology.com - This is an answer to a question that was asked when I did my Anatomy & Physiology Academy on how exactly resistance work...  
YouTube
about 5 years ago
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Plant protein could be used for blood, say scientists - BBC News

A protein found in sugar beet that is related to haemoglobin in human blood could be used as a blood substitute, say researchers in Sweden.  
BBC News
about 5 years ago