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CriticalCare

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Critical Care

Neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (Cys-C), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) are novel diagnostic biomarkers of acute kidney injury (AKI). We aimed to determine the diagnostic properties of these biomarkers for detecting AKI in critically ill patients with sepsis.  
ccforum.com
almost 6 years ago
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15

Critical Care

Acute Kidney Injury (AKI) is common in critical ill populations and its association with high short-term mortality is well established. However, long-term risks of death and renal dysfunction are poorly understood and few studies exclude patients with pre-existing renal disease, meaning outcome for de novo AKI has been difficult to elicit. We aimed to compare the long-term risk of Chronic Kidney Disease (CKD), End Stage Renal Disease (ESRD) and mortality in critically ill patients with and without severe de novo AKI.  
ccforum.com
almost 6 years ago
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6

Critical Care

Pseudomonas aeruginosa nosocomial pneumonia (Pa-NP) is associated with considerable morbidity, prolonged hospitalization, increased costs, and mortality.  
ccforum.com
almost 6 years ago
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7

Critical Care

The modern-era abdominal compartment syndrome (ACS) was first described as a ‘new’ clinical entity in the 1980s in emergency surgery patients, despite being described over 100 years earlier [1]. This stimulated scientific research leading to a better understanding of ACS, and the development of strategies to prevent and treat the condition [2]. Simultaneously, several investigators described the impact of the prelude to ACS – intra-abdominal hypertension (IAH), where organ function is impaired at lower intra-abdominal pressure (IAP) in the range of 12–20 mmHg [3]. This new knowledge has improved our understanding of the interactions between the different body compartments and new pathophysiologic terms have been coined, such as the polycompartment syndrome [4]. Within this concept, abdominal wall compliance seems to be a key factor that has only recently been better investigated [5].  
ccforum.com
almost 6 years ago
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3

Radiology Case 21 - Intensive Care Network

Aortic dissection case presentation & CT scan.  
intensivecarenetwork.com
almost 6 years ago
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2

Critical Care

Diffuse alveolar damage (DAD) is the pathological hallmark of acute respiratory distress syndrome (ARDS), however, the presence of DAD in the clinical criteria of ARDS patients by Berlin definition is little known. This study is designed to investigate the role of DAD in ARDS patients who underwent open lung biopsy.  
ccforum.com
almost 6 years ago
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Critical Care

The purpose of this study was to evaluate the clinical relevance of high values of central venous-to-arterial carbon dioxide difference (PCO2 gap) in high-risk surgical patients admitted to a postoperative ICU. We hypothesized that PCO2 gap could serve as a useful tool to identify patients still requiring hemodynamic optimization at ICU admission.  
ccforum.com
almost 6 years ago
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1

Critical Care

Acute respiratory distress syndrome (ARDS) is a major cause of mortality in intensive care units. As there is rising evidence about immuno-modulatory effects of lipid emulsions required for parenteral nutrition of ARDS patients, we sought to investigate whether infusion of conventional soybean oil (SO)-based or fish oil (FO)-based lipid emulsions rich in either n-6 or n-3 fatty acids, respectively, may influence subsequent pulmonary inflammation.  
ccforum.com
almost 6 years ago
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4

Critical Care

The Tie2/angiopoietin (Tie2/Ang) and vascular endothelial growth factor receptor-ligand systems (VEGFR/VEGF) are recognized to play important roles in the regulation of microvascular endothelial function. Downregulation of these genes during sepsis has been implicated in the pathogenesis of sepsis-related microvascular leak and multiple organ dysfunction syndrome. Mechanisms responsible for dysregulation of angiogenic genes in sepsis are poorly defined.  
ccforum.com
almost 6 years ago
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Critical Care

There is increasing recognition of the stress and burnout suffered by critical care workers. Physicians have a responsibility to teach learners the skills required not only to treat patients, but to cope with the demands of a stressful profession. Humor has been neglected as a strategy to help learners develop into virtuous and resilient physicians. Humor can be used to reduce stress, address fears, and to create effective health care teams. However, there are forms of humor which can be hurtful or discriminatory. In order to maximize the benefits of humor and to reduce its harms, we need to teach and model the effective and virtuous use of humor in the intensive care unit.  
ccforum.com
almost 6 years ago
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11

Radiology Case 22 - Intensive Care Network

The CT Cerebral Angiogram and 3D Reconstruction confirmed a 12 x 18mm basilar tip aneurysm. Incidentally, the left posterior cerebral artery has a fetal origin (supplied by left posterior communicating artery) – a normal variant.  
intensivecarenetwork.com
almost 6 years ago