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BNPA special: The prospects of a vaccine for Alzheimer's disease

Stream BNPA special: The prospects of a vaccine for Alzheimer's disease by BMJ talk medicine from desktop or your mobile device  
feeds.bmj.com
over 5 years ago
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Diagnosing the dementias

Stream Diagnosing the dementias by BMJ talk medicine from desktop or your mobile device  
feeds.bmj.com
over 5 years ago
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Dimebon for Alzheimer's disease | Cochrane

Alzheimer’s disease (AD) is a degenerative disorder of the brain. It is expected to be four times more common in 2050 than it was in 2006. Common symptoms of AD include memory loss, difficulties completing daily tasks, and changes in mood, behaviour and personality. Currently approved drug treatments for AD have only modest benefits and have not been shown to slow down the progression of the disease. There is a need for more effective drugs. Latrepirdine (also known as Dimebon) has been suggested as a potential treatment for AD and other dementias. Clinical studies have had conflicting findings, so we conducted a systematic review and pooled all the available data to assess the effects of latrepirdine. We looked for studies to help us answer this question by conducting a literature search in June 2014. We combined data from seven studies with a total of 1697 patients with AD. We were unable to conclude whether latrepirdine has any beneficial effect on cognition and function in people with AD due to variations in the results between studies and because the effects we estimated were too imprecise. However, the evidence suggests that latrepirdine may have a positive effect in treating behavioural symptoms, and that it is not associated with adverse effects in people with AD. Although seven studies have been done, data from only six studies were available and most of the studies were not fully reported. We contacted the investigators for additional data but received no response.  
cochrane.org
over 5 years ago
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Exercise programs for people with dementia | Cochrane

In future, as the population ages, the number of people in our communities suffering with dementia will rise dramatically. This will not only affect the quality of life of people with dementia but also increase the burden on family caregivers, community care, and residential care services. Exercise is one lifestyle factor that has been identified as a potential means of reducing or delaying progression of the symptoms of dementia.  
cochrane.org
over 5 years ago
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Rivastigmine for people with Alzheimer's disease | Cochrane

We reviewed evidence comparing the effectiveness and safety of rivastigmine with placebo in people with Alzheimer's disease. Background  
cochrane.org
over 5 years ago
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143

A Guide to Dementia

Epidemiology & societal impact, genetic and other risk factors, differential diagnosis of dementia assessment methods, agitation, treatment & management and references.  
hopkinsmedicine.org
over 5 years ago
 82929886 de30
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How dance classes are helping people with dementia - BBC News

Studies have shown that dance could improve the lives of dementia sufferers - Lizzie Crouch visits a class in east London.  
bbc.co.uk
over 5 years ago
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Opioids for agitation in dementia | Cochrane

Opioids (such as morphine and codeine) are strong painkillers best known as treatments for post-surgical and cancer pain. They are also used for long-term painful conditions other than cancer and sometimes for symptoms other than pain. They have a number of important adverse effects and their use involves a balance of risks and benefits.  
cochrane.org
over 5 years ago
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Frontotemporal Dementia | Signs, Symptoms, & Diagnosis

Frontotemporal dementia is a rare disorder, related to Alzheimer's disease. Learn about frontotemporal dementia and Pick's disease causes, signs and symptoms and treatment and get support resources.  
alz.org
over 5 years ago
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The top four modern killers in the west

Cancer, dementia, heart disease and new – or new strains of – infectious diseases are what modern westerners are dying of now  
theguardian.com
over 5 years ago
Www.bmj
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Dementia: timely diagnosis and early intervention

Dementia is a major global health problem; in the absence of a cure there is increasing focus on risk reduction, timely diagnosis, and early intervention  
feeds.bmj.com
over 5 years ago
Www.bmj
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Naturally occurring genetic variation that prevents prion disease is identified

A naturally occurring variant of the human prion protein that produces complete resistance to prion diseases such as Creutzfeldt-Jakob disease (CJD) has been identified. The researchers said that the findings, published in Nature, could provide important insights into dementia and help to guide research into new treatments.1  
feeds.bmj.com
over 5 years ago
Www.bmj
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Naturally occurring genetic variation that prevents prion disease is identified

A naturally occurring variant of the human prion protein that produces complete resistance to prion diseases such as Creutzfeldt-Jakob disease (CJD) has been identified. The researchers said that the findings, published in Nature, could provide important insights into dementia and help to guide research into new treatments.1  
feeds.bmj.com
over 5 years ago
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Cognivue Automated Cerebral Assessment System FDA Approved to Detect Early Signs of Dementia |

Cognitive assessment for detecting early signs of dementia and for tracking therapy effectiveness is normally performed by trained professionals using spec  
medgadget.com
over 5 years ago
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Rehabilitation for people with dementia following a hip fracture operation | Cochrane

Hip fracture is an injury primarily of elderly people, usually caused by a fall. It can affect a person's ability to walk, perform activities of daily living and remain independent. Hip fracture is more common in people with dementia and they can find it more difficult to recover. This is because they are at greater risk of becoming more confused and developing additional complications such as pressure sores and chest infections after their operation. They may also find it more difficult to express their pain and discomfort.  
cochrane.org
over 5 years ago
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Drivers with early dementia are a 'risk to the public' - BBC News

Drivers in the early stages of dementia could be posing a risk to the public, doctors are warning.  
bbc.co.uk
over 5 years ago
Www.bmj
0
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Predicting dementia

Nobody will dispute that people seeking medical advice for cognitive complaints, behavioural problems, or mood changes deserve access to a careful clinical assessment. Above all, comprehensive appraisal of possible early signs of dementia requires time, knowledge, and experience. It can lead to either reassurance, identification of remediable causes for the complaints, or a diagnosis of dementia. In the latter case, people with dementia and their carers could benefit from professional support to prepare for the important changes in functioning that lie ahead and the necessary decisions on living accommodation or any other aspect of care. Depending on the specific clinical profile of symptoms, they can be offered symptomatic drug treatment.  
feeds.bmj.com
over 5 years ago
Www.bmj
0
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Predicting dementia

Nobody will dispute that people seeking medical advice for cognitive complaints, behavioural problems, or mood changes deserve access to a careful clinical assessment. Above all, comprehensive appraisal of possible early signs of dementia requires time, knowledge, and experience. It can lead to either reassurance, identification of remediable causes for the complaints, or a diagnosis of dementia. In the latter case, people with dementia and their carers could benefit from professional support to prepare for the important changes in functioning that lie ahead and the necessary decisions on living accommodation or any other aspect of care. Depending on the specific clinical profile of symptoms, they can be offered symptomatic drug treatment.  
feeds.bmj.com
over 5 years ago
Www.bmj
0
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Usefulness of data from magnetic resonance imaging to improve prediction of dementia: population based cohort study

Objective To determine whether the addition of data derived from magnetic resonance imaging (MRI) of the brain to a model incorporating conventional risk variables improves prediction of dementia over 10 years of follow-up.  
feeds.bmj.com
over 5 years ago
Www.bmj
0
2

Predicting dementia

Nobody will dispute that people seeking medical advice for cognitive complaints, behavioural problems, or mood changes deserve access to a careful clinical assessment. Above all, comprehensive appraisal of possible early signs of dementia requires time, knowledge, and experience. It can lead to either reassurance, identification of remediable causes for the complaints, or a diagnosis of dementia. In the latter case, people with dementia and their carers could benefit from professional support to prepare for the important changes in functioning that lie ahead and the necessary decisions on living accommodation or any other aspect of care. Depending on the specific clinical profile of symptoms, they can be offered symptomatic drug treatment.  
feeds.bmj.com
over 5 years ago