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Idarubicin for treatment of newly diagnosed acute myeloid leukaemia | Cochrane

Acute myeloid leukaemia (AML) is a type of cancer that mainly affects bone marrow and peripheral blood. Although 40% to 45% of AML patients enjoy long-term disease-free survival, most patients will die of the disease. Induction therapy is the first phase of treatment of newly diagnosed AML which is essential for prolonging survival. An anthracycline (a class of chemotherapy drugs derived from the Streptomyces bacterium Streptomyces peucetius var. caesius) combined with cytarabine (a chemotherapy drug used mainly in treatment of haematological malignancies) has remained the standard of induction therapy for several decades. Nowadays there are several kinds of anthracyclines available, among which idarubicin (IDA) draws more attention because of its theoretical advantages in improving efficacy and reducing side effects. However, clinical trials comparing IDA with other anthracyclines have conflicting results.  
cochrane.org
about 5 years ago
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Taxane-containing regimens for metastatic breast cancer | Cochrane

We reviewed the evidence about the effect of taxane-containing chemotherapy regimens in women with metastatic breast cancer. This is an update of a Cochrane review first published in 2003.  
cochrane.org
about 5 years ago
Www.bmj
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Overdiagnosis of bone fragility in the quest to prevent hip fracture

Despite widespread endorsement, Teppo Järvinen and colleagues argue that evidence for stratifying risk of fracture and subsequent drug therapy to prevent hip fracture is insufficient to warrant our current approach  
feeds.bmj.com
about 5 years ago
Www.bmj
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Overdiagnosis of bone fragility in the quest to prevent hip fracture

Despite widespread endorsement, Teppo Järvinen and colleagues argue that evidence for stratifying risk of fracture and subsequent drug therapy to prevent hip fracture is insufficient to warrant our current approach  
feeds.bmj.com
about 5 years ago
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Cost-effectiveness of hormone replacement therapy for menopausal symptoms in the UK

This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn.  
crd.york.ac.uk
about 5 years ago
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Hormone replacement therapy (HRT) - Side effects - NHS Choices

Both of the hormones that are used in hormone replacement therapy (HRT), oestrogen and progestogen, have side effects.  
nhs.uk
about 5 years ago
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Hormone replacement therapy (HRT) - NHS Choices

Hormone replacement therapy (HRT) is a treatment used to relieve symptoms of the menopause. It replaces female hormones that are at a lower level as you approach the menopause.  
nhs.uk
about 5 years ago
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'Prostate cancer drug Docetaxel extended my life' - BBC News

Early treatment with a chemotherapy drug, Docetaxel, extends the lives of patients with advanced prostate cancer by nearly two years, a major study shows.  
bbc.co.uk
about 5 years ago
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Prostate cancer drug 'extends lives' - BBC News

A chemotherapy drug can extend the lives of patients with advanced prostate cancer by nearly two years, a major "game-changing" study shows.  
bbc.co.uk
about 5 years ago
Identrx
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IdentRx Promises to Prevent Nearly All Medication Errors |

Medication errors continue to plague the clinical community and even rare cases of mistakes can make a big splash in the news. And for a good reason: we al  
medgadget.com
over 5 years ago
Www.bmj
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PET after chemotherapy identifies Hodgkin’s lymphoma patients who can avoid radiotherapy

Positron emission tomography (PET) scanning immediately after chemotherapy for Hodgkin’s lymphoma can identify patients who are likely to have good survival without radiotherapy, a study reported in the New England Journal of Medicine has found.1  
feeds.bmj.com
over 5 years ago
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WHAT IS DENTAL ONCOLOGY? — Something to Sink Your Teeth Into

Dental Oncology is an area of dentistry focusing on the dental and oral manifestations of chemotherapy, radiation therap…  
medium.com
over 5 years ago
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Cancer vaccines

Cancer vaccines are designed to promote tumor specific immune responses, particularly cytotoxic CD8 positive T cells that are specific to tumor antigens. The earliest vaccines, which were developed in 1994-95, tested non-mutated, shared tumor associated antigens that had been shown to be immunogenic and capable of inducing clinical responses in a minority of people with late stage cancer. Technological developments in the past few years have enabled the investigation of vaccines that target mutated antigens that are patient specific. Several platforms for cancer vaccination are being tested, including peptides, proteins, antigen presenting cells, tumor cells, and viral vectors. Standard of care treatments, such as surgery and ablation, chemotherapy, and radiotherapy, can also induce antitumor immunity, thereby having cancer vaccine effects. The monitoring of patients’ immune responses at baseline and after standard of care treatment is shedding light on immune biomarkers. Combination therapies are being tested in clinical trials and are likely to be the best approach to improving patient outcomes.  
feeds.bmj.com
over 5 years ago
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Cancer vaccines

Cancer vaccines are designed to promote tumor specific immune responses, particularly cytotoxic CD8 positive T cells that are specific to tumor antigens. The earliest vaccines, which were developed in 1994-95, tested non-mutated, shared tumor associated antigens that had been shown to be immunogenic and capable of inducing clinical responses in a minority of people with late stage cancer. Technological developments in the past few years have enabled the investigation of vaccines that target mutated antigens that are patient specific. Several platforms for cancer vaccination are being tested, including peptides, proteins, antigen presenting cells, tumor cells, and viral vectors. Standard of care treatments, such as surgery and ablation, chemotherapy, and radiotherapy, can also induce antitumor immunity, thereby having cancer vaccine effects. The monitoring of patients’ immune responses at baseline and after standard of care treatment is shedding light on immune biomarkers. Combination therapies are being tested in clinical trials and are likely to be the best approach to improving patient outcomes.  
feeds.bmj.com
over 5 years ago
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Avoiding Resuscitation Medication Errors - Part I

I am joined by Bryan Hayes to discuss the avoidance of critical medication errors during resuscitations.  
emcrit.org
over 5 years ago
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Concurrent chemoradiation treatment at high-volume facilities improves survival for NSCLC

Patients treated with definitive concurrent chemotherapy and radiation therapy (CCRT) for stage III non-small cell lung cancer (NSCLC) have longer overall survival when treated by highly...  
medicalnewstoday.com
over 5 years ago
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Label design may affect risk of medication errors in OR, reports Journal of Patient Safety

Redesigned labels reduce the number of errors in simulated surgical emergency, study findsSpecial redesigned labels for intravenous (IV) medication bags may help to...  
medicalnewstoday.com
over 5 years ago
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Seeking new targets for ovarian cancer treatment

Identifying molecular changes that occur in tissue after chemotherapy could be crucial in advancing treatments for ovarian cancer, according to research from Magee-Womens Research Institute and...  
medicalnewstoday.com
over 5 years ago
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Magee, UPCI researchers seek new targets for ovarian cancer treatment

Identifying molecular changes that occur in tissue after chemotherapy could be crucial in advancing treatments for ovarian cancer, according to research from Magee-Womens Research Institute...  
medicalnewstoday.com
over 5 years ago
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Women with ovarian cancer gain extra months with addition of drug to standard chemotherapy

Medical researchers are always looking for ways to prevent or cure cancer. Given the complexity of this disease, reaching these milestones has been difficult.  
medicalnewstoday.com
over 5 years ago