New to Meducation?
Sign up
Already signed up? Log In

Category

Preview
0
0

The Underutilization of Intraperitoneal Chemotherapy

Dr Maurie Markman expresses concern over a recent report illustrating the underuse of intraperitoneal chemotherapy for ovarian cancer, despite evidence that this therapy improves survival rates.  
medscape.com
about 4 years ago
Preview
0
6

Nivolumab: Immunotherapy in Malignant Melanoma

Melanoma rates have been steadily increasing since the 1970s, but cytotoxic chemotherapy generally prolongs survival.  
medscape.com
about 4 years ago
Preview
0
0

With better adjuvant therapy, does breast cancer stage still matter?

Breast cancer mortality is declining throughout the Western world.1 2 3 If, as J F Kennedy said, “victory has a thousand fathers,” then progress in breast cancer surely has a lot of parents. In the late 1970s, guidelines recommended screening mammography for women over the age of 40, resulting in implementation of national and regional screening programmes in most developed countries. Soon after, adjuvant endocrine therapy and chemotherapy were found to reduce the risk of breast cancer recurrence and death.4 5 Meanwhile, the combination of early detection and effective radiation therapy enabled breast conserving surgery as an option for most women.6 The implementation of these truly multidisciplinary treatment programmes, combining local and systemic treatments with public health screening initiatives and health awareness campaigns, revolutionised and improved breast cancer care.  
feeds.bmj.com
about 4 years ago
Preview
0
0

With better adjuvant therapy, does breast cancer stage still matter?

Breast cancer mortality is declining throughout the Western world.1 2 3 If, as J F Kennedy said, “victory has a thousand fathers,” then progress in breast cancer surely has a lot of parents. In the late 1970s, guidelines recommended screening mammography for women over the age of 40, resulting in implementation of national and regional screening programmes in most developed countries. Soon after, adjuvant endocrine therapy and chemotherapy were found to reduce the risk of breast cancer recurrence and death.4 5 Meanwhile, the combination of early detection and effective radiation therapy enabled breast conserving surgery as an option for most women.6 The implementation of these truly multidisciplinary treatment programmes, combining local and systemic treatments with public health screening initiatives and health awareness campaigns, revolutionised and improved breast cancer care.  
feeds.bmj.com
about 4 years ago
Preview
0
0

Combining Immunotherapy and Anticancer Agents

Learn more about the immune-mediated effects of chemotherapy and their clinical relevance, the biological and clinical features of immune checkpoint blockers and more.  
medscape.com
about 4 years ago
Preview
0
0

High-dose chemotherapy and stem cell transplant compared to conventional therapy for children with high-risk neuroblastoma | Cochrane

Despite the development of new treatment options, the prognosis of high-risk neuroblastoma patients still remains poor; in more than half of patients the disease returns. Stem cell rescue replaces blood-forming stem cells that were destroyed by high-dose chemotherapy in order to recover the bone marrow. It is also known as myeloablative therapy and might improve the survival of these patients. A well-informed decision on the use of myeloablative therapy in the treatment of children with high-risk neuroblastoma should be based on high quality evidence of effectiveness for treating tumours and side effects.  
cochrane.org
about 4 years ago
Preview
0
0

Brentuximab -- First-Line Option in Elderly Hodgkin's Lymphoma

A phase 2 trial has shown that brentuximab vedotin monotherapy is safe and effective as first-line therapy in elderly lymphoma patients who cannot tolerate standard chemotherapy.  
medscape.com
about 4 years ago
Preview
1
77

Rethink urged on prostate drug use - BBC News

Senior doctors are calling for a rethink over the use of a chemotherapy drug to treat prostate cancer.  
bbc.co.uk
about 4 years ago
Preview
0
8

Prototype Device Allows for Real-Time White Cell Counts Through the Skin, Personalized Chemotherapy |

Team Leuko, an international group collaborating between the Massachusetts Institute of Technology (MIT) and a handful of centers, hospitals, and foundatio  
medgadget.com
about 4 years ago
Preview
0
24

Pharmacotherapy for Bipolar Depression

While this meta-analysis is the most current and comprehensive summary regarding drug treatments for bipolar depression--both approved and off-label--some of the conclusions may be controversial.  
medscape.com
about 4 years ago
Preview
0
0

Platelet transfusions to treat bleeding compared with platelet transfusions to prevent bleeding in people with blood cancers receiving intensive treatment | Cochrane

We evaluated the evidence regarding whether giving platelet transfusions to patients with low platelets who are bleeding (therapeutically) is as effective and safe as giving platelet transfusions regularly to prevent bleeding (prophylactically). Our target population was people with blood cancers who were receiving intensive myelosuppressive (causing decreased blood cell production) chemotherapy treatments or stem cell transplantation.  
cochrane.org
about 4 years ago
Preview
0
3

Guiding Fluid Therapy in High-Risk Thoracic Surgery

In 2009 the institutional guidelines changed for perioperative fluid therapy in patients undergoing extrapleural pneumonectomy. This study assesses the consequences of those changes.  
medscape.com
about 4 years ago
Preview
0
0

FDA OKs New Oral Drug for Refractory Colorectal Cancer

A new oral drug has been approved for use in patients with advanced colorectal cancer who are no longer responding to chemotherapy and biological agents.  
medscape.com
about 4 years ago
Preview
0
0

Microbiome Diversity Affects Chemotherapy-Related Infection

Analyzing the microbiome of patients with acute myelogenous leukemia during chemotherapy could help risk-stratify patients for infection, a new study suggests.  
medscape.com
about 4 years ago
Preview
0
0

Transiently Pink-Tinged Serum in a Patient on Lenalidomide

What was the cause of discolored serum in this multiple myeloma patient undergoing chemotherapy with lenalidomide?  
medscape.com
about 4 years ago
Preview
1
8

Evidence based medicine: what it is and what it isn't

Evidence based medicine, whose philosophical origins extend back to mid-19th century Paris and earlier, remains a hot topic for clinicians, public health practitioners, purchasers, planners, and the public. There are now frequent workshops in how to practice and teach it (one sponsored by the BMJ will be held in London on 24 April); undergraduate1 and postgraduate2 training programmes are incorporating it3 (or pondering how to do so); British centres for evidence based practice have been established or planned in adult medicine, child health, surgery, pathology, pharmacotherapy, nursing, general practice, and dentistry; the Cochrane Collaboration and Britain's Centre for Review and Dissemination in York are providing systematic reviews of the effects of health care; new evidence based practice journals are being launched; and it has become a common topic in the lay media. But enthusiasm has been mixed with some negative reaction.4 5 6 Criticism has ranged from evidence based medicine being old hat to it being a dangerous innovation, perpetrated by the arrogant to serve cost cutters and suppress clinical freedom. As evidence based medicine continues to evolve and adapt, now is a useful time to refine the discussion of what it is and what it is not.  
bmj.com
about 4 years ago
Preview
0
0

Smoking cessation and reduction in people with chronic mental illness

The high prevalence of cigarette smoking and tobacco related morbidity and mortality in people with chronic mental illness is well documented. This review summarizes results from studies of smoking cessation treatments in people with schizophrenia, depression, anxiety disorders, and post-traumatic stress disorder. It also summarizes experimental studies aimed at identifying biopsychosocial mechanisms that underlie the high smoking rates seen in people with these disorders. Research indicates that smokers with chronic mental illness can quit with standard cessation approaches with minimal effects on psychiatric symptoms. Although some studies have noted high relapse rates, longer maintenance on pharmacotherapy reduces rates of relapse without untoward effects on psychiatric symptoms. Similar biopsychosocial mechanisms are thought to be involved in the initiation and persistence of smoking in patients with different disorders. An appreciation of these common factors may aid the development of novel tobacco treatments for people with chronic mental illness. Novel nicotine and tobacco products such as electronic cigarettes and very low nicotine content cigarettes may also be used to improve smoking cessation rates in people with chronic mental illness.  
feeds.bmj.com
about 4 years ago
Preview
0
6

Electronic Medication Reconciliation and Medication Errors

This report evaluates the use of an electronic tool to reduce non-intercepted admission medication reconciliation errors in a children's hospital.  
medscape.com
about 4 years ago
Preview
0
12

Polypharmacy: An Obvious Problem in Need of Attention

A review paper questions the indefinite prescription of the big four cardiac drugs, reminding Dr Mandrola of David Foster Wallace's "This is Water" commencement speech challenging us to choose what to pay attention to.  
medscape.com
about 4 years ago
Preview
0
0

Risk-Adapted Therapy for Early-Stage Extranodal Nasal-Type NK/T-Cell Lymphoma: Analysis From a Multicenter Study: Abstract and Introduction

Abstract and Introduction: For patients with early-stage nasal-type extranodal NK/T-cell lymphoma, the most effective treatment was risk-adapted therapy of radiotherapy alone for the low-risk group and radiotherapy consolidated by chemotherapy for the high-risk group.  
medscape.org
about 4 years ago