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14

PET after chemotherapy identifies Hodgkin’s lymphoma patients who can avoid radiotherapy

Positron emission tomography (PET) scanning immediately after chemotherapy for Hodgkin’s lymphoma can identify patients who are likely to have good survival without radiotherapy, a study reported in the New England Journal of Medicine has found.1  
feeds.bmj.com
over 4 years ago
Identrx
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11

IdentRx Promises to Prevent Nearly All Medication Errors |

Medication errors continue to plague the clinical community and even rare cases of mistakes can make a big splash in the news. And for a good reason: we al  
medgadget.com
over 4 years ago
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3

Prostate cancer drug 'extends lives' - BBC News

A chemotherapy drug can extend the lives of patients with advanced prostate cancer by nearly two years, a major "game-changing" study shows.  
bbc.co.uk
over 4 years ago
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10

'Prostate cancer drug Docetaxel extended my life' - BBC News

Early treatment with a chemotherapy drug, Docetaxel, extends the lives of patients with advanced prostate cancer by nearly two years, a major study shows.  
bbc.co.uk
over 4 years ago
Www.bmj
0
7

Overdiagnosis of bone fragility in the quest to prevent hip fracture

Despite widespread endorsement, Teppo Järvinen and colleagues argue that evidence for stratifying risk of fracture and subsequent drug therapy to prevent hip fracture is insufficient to warrant our current approach  
feeds.bmj.com
over 4 years ago
Www.bmj
0
4

Overdiagnosis of bone fragility in the quest to prevent hip fracture

Despite widespread endorsement, Teppo Järvinen and colleagues argue that evidence for stratifying risk of fracture and subsequent drug therapy to prevent hip fracture is insufficient to warrant our current approach  
feeds.bmj.com
over 4 years ago
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0
2

Taxane-containing regimens for metastatic breast cancer | Cochrane

We reviewed the evidence about the effect of taxane-containing chemotherapy regimens in women with metastatic breast cancer. This is an update of a Cochrane review first published in 2003.  
cochrane.org
over 4 years ago
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9

Idarubicin for treatment of newly diagnosed acute myeloid leukaemia | Cochrane

Acute myeloid leukaemia (AML) is a type of cancer that mainly affects bone marrow and peripheral blood. Although 40% to 45% of AML patients enjoy long-term disease-free survival, most patients will die of the disease. Induction therapy is the first phase of treatment of newly diagnosed AML which is essential for prolonging survival. An anthracycline (a class of chemotherapy drugs derived from the Streptomyces bacterium Streptomyces peucetius var. caesius) combined with cytarabine (a chemotherapy drug used mainly in treatment of haematological malignancies) has remained the standard of induction therapy for several decades. Nowadays there are several kinds of anthracyclines available, among which idarubicin (IDA) draws more attention because of its theoretical advantages in improving efficacy and reducing side effects. However, clinical trials comparing IDA with other anthracyclines have conflicting results.  
cochrane.org
over 4 years ago
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12

Antibiotic prophylaxis during the second and third trimester in pregnancy to reduce adverse pregnancy outcomes and morbidity | Cochrane

Antibiotics are administered to pregnant women during the second and third trimester of pregnancy (before labour) to prevent bacteria in the vagina and cervix affecting the pregnancy. Infection by some infectious organisms in a woman’s genital tract can cause health problems for the mother and her baby, and has been associated with preterm births. This review of eight randomised trials involved approximately 4300 women in their second or third trimester. We found that antibiotics did not reduce the risk of preterm prelabour rupture of the membranes (one trial, low quality of evidence), or the risk of preterm birth (six trials, high quality of evidence). Preterm delivery was reduced in pregnant women who had a previous preterm birth and an imbalance of bacteria in the vagina (bacterial vaginosis) during the current pregnancy. There was no reduction in preterm delivery in pregnant women with previous preterm birth without a bacterial imbalance during the current pregnancy (two trials). Postpartum endometritis, or infection of the uterus following birth, was reduced overall (three trials, moderate quality of evidence), as well as in a trial of high-risk women who had a previous preterm birth (one trial, moderate quality of evidence). No reduction in neonatal illness was observed. Outcomes of interest were available in trials with high losses to follow-up. We could not estimate the side effects of antibiotics since side effects were rare; however, antibiotics may still have serious side effects on women and their babies.  
cochrane.org
over 4 years ago
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0

Lab-on-a-Chip Simulates Heartbeat for Testing New Drug Therapies (VIDEO) |

Our hearts evolved to pump blood in a pulsing manner. The heartbeat that nearly the entire body experiences may be important for a variety of biological pr  
medgadget.com
over 4 years ago
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7

Drug therapy for treating systemic intravascular activation of coagulation in patients with leukemia | Cochrane

Review question We reviewed the clinical benefits and harms of anticoagulant and antifibrinolytic therapy for treating disseminated intravascular coagulation (DIC) in patients with acute or chronic leukemia.  
cochrane.org
over 4 years ago
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6

Tumour biomarkers: diagnostic, prognostic, and predictive

A 63 year old woman presented with a one month history of difficulty speaking and imbalance. She had been diagnosed with breast cancer two years earlier and had been treated with surgery, chemotherapy, and radiotherapy. This was followed by a year of trastuzumab (Herceptin) and continuous tamoxifen treatment.  
feeds.bmj.com
over 4 years ago
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8

Drug prescriptions rise in England - BBC News

An extra 34.5 million drugs and other prescription items were given out in 2014 compared to the year before, the latest snapshot for England shows.  
bbc.co.uk
over 4 years ago
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5

'Softener' may help kill cancers - BBC News

It may be possible to "soften-up" cancer cells before hitting them with chemotherapy drugs, researchers suggest.  
bbc.co.uk
over 4 years ago
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9

Pharmacotherapy for weight loss

A severely obese 28 year old woman (body mass index (BMI) 37.9) with type 2 diabetes, controlled hypertension, and sleep apnoea is seeking your advice about weight loss. She has lost 6 kg over the past year by reducing portion sizes, but her weight has recently plateaued. She does not want to consider bariatric surgery and asks instead about drug treatments.  
feeds.bmj.com
about 4 years ago
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8

Chemotherapy does not improve quality of life in cancer patients at end of life, US study finds

Chemotherapy for patients with end stage cancer did not improve quality of life in those with poor or moderate performance status and worsened it in those with good performance status, US researchers have found.1  
feeds.bmj.com
about 4 years ago
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2

A comparison of platinum-based and non-platinum-based chemotherapy regimens for the treatment of small cell lung cancer | Cochrane

Do patients with small cell lung cancer (SCLC) who receive platinum-based chemotherapy treatment live longer than those who receive non-platinum-based chemotherapy treatment?  
cochrane.org
about 4 years ago
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13

Effective ovarian cancer treatment is underused, US study finds

Six years after the US National Cancer Institute issued a special clinical announcement encouraging the use of intraperitoneal and intravenous chemotherapy for ovarian cancer, less than half of eligible women were being treated with it, a new study has found.1  
feeds.bmj.com
about 4 years ago
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2

Interventions for leg cramps during pregnancy | Cochrane

Leg cramps are experienced as sudden, intense involuntary contractions of the leg muscles. They are a common problem in pregnancy, especially in the third trimester. They are painful and can interfere with daily activities, disrupt sleep, and reduce quality of life. Various interventions have been used during pregnancy to treat leg cramps, including drug, electrolyte (magnesium, calcium, sodium) and vitamin therapies, and non-drug therapies such as muscle stretching. The goal of this review was to find out what is effective and safe for treating leg cramps during pregnancy.  
cochrane.org
about 4 years ago
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8

Oncologic Emergencies Part I: Pearls and Pitfalls - emdocs

A great review of emergencies caused by metastatic cancer, chemotherapy, and radiation  
emdocs.net
about 4 years ago