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Adding Chemotherapy to Radiotherapy Extends Glioma Survival

For patients with low-grade glioma, progression-free and overall survival are better when chemotherapy is added to radiotherapy, long-term results confirm.  
medscape.com
over 3 years ago
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A Major Advance Against Chemotherapy's Most Feared Side Effect

Dr Mark Kris discusses a study showing that olanzapine is safe and effective for chemotherapy-induced nausea and emesis.  
medscape.com
over 3 years ago
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Pharmacotherapies in Cardiac Critical Care Immune Therapy

In this article, the current immunomodulatory treatments in pediatric cardiac disease and heart transplantation patients are reviewed.  
medscape.com
over 3 years ago
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Uneven Use of Antibiotic Prophylaxis in Pediatric Surgery

Antibiotic prophylaxis rates varied greatly among pediatric hospitals; it was both over- and underused.  
medscape.com
over 3 years ago
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1

MammaPrint Shows Which Breast Cancer Patients Can Skip Chemo

The first outcome data from a huge European trial show that the 70-gene assay can identify patients who can safety skip chemotherapy.  
medscape.com
over 3 years ago
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Large B-Cell Transformation in Nodular Lymphocyte-Predominant Hodgkin Lymphoma: 40-Year Experience from a Single Institution: Abstract and Introduction

Abstract and Introduction: Risk factors for transformation of nodular lymphocyte predominant Hodgkin lymphoma to diffuse large B-cell lymphoma include previous chemotherapy and splenic involvement at the time of diagnosis.  
medscape.org
over 3 years ago
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Bacterial Product Boosts Mesothelioma Chemotherapy Response

Response rates to chemotherapy among patients with mesothelioma are substantially increased by adding a live, attenuated bacterium expressing a tumor-associated antigen, US trial results indicate.  
medscape.com
over 3 years ago
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Anthracyclines No Worse for Cognition in Breast Cancer Study

Cognitive decline was not in evidence for up to 7 years in a longitudinal prospective study of patients who did and did not receive chemotherapy (including anthracyclines).  
medscape.com
over 3 years ago
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Pulmonary nodules in a man with a history of bone marrow transplantation

Our patient was diagnosed as having Philadelphia chromosome positive pre-B acute lymphoblastic leukaemia with lymphoid blast crisis (blast crisis of chronic myeloid leukaemia) in 2011. Treatment with two cycles of hyper-CVAD (alternating cyclophosphamide+vincristine+doxorubicin+dexamethasone with methotrexate+cytarabine) plus dasatinib resulted in a negative bone marrow biopsy (remission). He had an allogeneic peripheral blood stem cell transplant from a 10/10 HLA matched unrelated donor in 2013. Conditioning was with cyclophosphamide and 1200 cGy total body irradiation. Graft versus host disease prophylaxis was with tacrolimus and methotrexate. Dasatinib was continued after his transplant. In late 2013 he developed relapsed acute lymphoblastic leukaemia. He was treated with fludarabine, cytarabine, and granulocyte colony stimulating factor. Bone marrow biopsy after chemotherapy showed persistent acute lymphoblastic leukaemia, even after he was switched to ponatinib and dexamethasone. Daunorubicin and vincristine were added for one cycle but were discontinued when he was admitted to hospital for cellulitis. Bone marrow biopsy was negative but one three months later showed recurrent acute B lymphoblastic leukaemia. Remission occurred after re-induction with clofarabine in the autumn of 2014; this was followed by 6-mercaptopurine, methotrexate, vincristine, and prednisone maintenance therapy.  
feeds.bmj.com
over 3 years ago
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9

Pulmonary nodules in a man with a history of bone marrow transplantation

Our patient was diagnosed as having Philadelphia chromosome positive pre-B acute lymphoblastic leukaemia with lymphoid blast crisis (blast crisis of chronic myeloid leukaemia) in 2011. Treatment with two cycles of hyper-CVAD (alternating cyclophosphamide+vincristine+doxorubicin+dexamethasone with methotrexate+cytarabine) plus dasatinib resulted in a negative bone marrow biopsy (remission). He had an allogeneic peripheral blood stem cell transplant from a 10/10 HLA matched unrelated donor in 2013. Conditioning was with cyclophosphamide and 1200 cGy total body irradiation. Graft versus host disease prophylaxis was with tacrolimus and methotrexate. Dasatinib was continued after his transplant. In late 2013 he developed relapsed acute lymphoblastic leukaemia. He was treated with fludarabine, cytarabine, and granulocyte colony stimulating factor. Bone marrow biopsy after chemotherapy showed persistent acute lymphoblastic leukaemia, even after he was switched to ponatinib and dexamethasone. Daunorubicin and vincristine were added for one cycle but were discontinued when he was admitted to hospital for cellulitis. Bone marrow biopsy was negative but one three months later showed recurrent acute B lymphoblastic leukaemia. Remission occurred after re-induction with clofarabine in the autumn of 2014; this was followed by 6-mercaptopurine, methotrexate, vincristine, and prednisone maintenance therapy.  
feeds.bmj.com
over 3 years ago
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0
8

Pulmonary nodules in a man with a history of bone marrow transplantation

Our patient was diagnosed as having Philadelphia chromosome positive pre-B acute lymphoblastic leukaemia with lymphoid blast crisis (blast crisis of chronic myeloid leukaemia) in 2011. Treatment with two cycles of hyper-CVAD (alternating cyclophosphamide+vincristine+doxorubicin+dexamethasone with methotrexate+cytarabine) plus dasatinib resulted in a negative bone marrow biopsy (remission). He had an allogeneic peripheral blood stem cell transplant from a 10/10 HLA matched unrelated donor in 2013. Conditioning was with cyclophosphamide and 1200 cGy total body irradiation. Graft versus host disease prophylaxis was with tacrolimus and methotrexate. Dasatinib was continued after his transplant. In late 2013 he developed relapsed acute lymphoblastic leukaemia. He was treated with fludarabine, cytarabine, and granulocyte colony stimulating factor. Bone marrow biopsy after chemotherapy showed persistent acute lymphoblastic leukaemia, even after he was switched to ponatinib and dexamethasone. Daunorubicin and vincristine were added for one cycle but were discontinued when he was admitted to hospital for cellulitis. Bone marrow biopsy was negative but one three months later showed recurrent acute B lymphoblastic leukaemia. Remission occurred after re-induction with clofarabine in the autumn of 2014; this was followed by 6-mercaptopurine, methotrexate, vincristine, and prednisone maintenance therapy.  
feeds.bmj.com
over 3 years ago
Preview
0
8

Pulmonary nodules in a man with a history of bone marrow transplantation

Our patient was diagnosed as having Philadelphia chromosome positive pre-B acute lymphoblastic leukaemia with lymphoid blast crisis (blast crisis of chronic myeloid leukaemia) in 2011. Treatment with two cycles of hyper-CVAD (alternating cyclophosphamide+vincristine+doxorubicin+dexamethasone with methotrexate+cytarabine) plus dasatinib resulted in a negative bone marrow biopsy (remission). He had an allogeneic peripheral blood stem cell transplant from a 10/10 HLA matched unrelated donor in 2013. Conditioning was with cyclophosphamide and 1200 cGy total body irradiation. Graft versus host disease prophylaxis was with tacrolimus and methotrexate. Dasatinib was continued after his transplant. In late 2013 he developed relapsed acute lymphoblastic leukaemia. He was treated with fludarabine, cytarabine, and granulocyte colony stimulating factor. Bone marrow biopsy after chemotherapy showed persistent acute lymphoblastic leukaemia, even after he was switched to ponatinib and dexamethasone. Daunorubicin and vincristine were added for one cycle but were discontinued when he was admitted to hospital for cellulitis. Bone marrow biopsy was negative but one three months later showed recurrent acute B lymphoblastic leukaemia. Remission occurred after re-induction with clofarabine in the autumn of 2014; this was followed by 6-mercaptopurine, methotrexate, vincristine, and prednisone maintenance therapy.  
feeds.bmj.com
over 3 years ago
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Pharmacotherapies in Cardiac Critical Care

What do we know about the currently available sedative and analgesic agents for pediatric cardiac ICU patients?  
medscape.com
over 3 years ago
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Scalp Cooling Safe, Long-term European Data Show

Scalp cooling, which reduces hair loss during chemotherapy, has not been embraced in the United States, although 40 years of European data show that it is safe.  
medscape.com
over 3 years ago
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VANISH: Ablation for Recurrent VT Bests Intensified Amiodarone

Catheter ablation reduced the primary outcome compared with aggressive drug therapy and should be the preferred treatment in this population, the authors said.  
medscape.com
over 3 years ago
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Surgical Management of Intrahepatic Cholangiocarcinoma

Learn about new post-surgical options for intrahepatic cholangiocarcinoma treatment including proton beam therapy and updated chemotherapy regimens.  
medscape.com
over 3 years ago
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1

Pancreatic Cancer: Chemoradiotherapy vs Chemo Alone

Results from the LAP07 trial show no survival advantage for chemoradiotherapy vs chemotherapy alone in locally advanced pancreatic cancer.  
medscape.com
over 3 years ago
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1

Antipsychotics for Prevention and Treatment of Delirium

Antipsychotic pharmacotherapy is often used to prevent or treat delirium in hospitalized adults, but does evidence support its effectiveness?  
medscape.com
over 3 years ago
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1

Neoadjuvant Chemoradiotherapy and Surgery in Rectal Cancer

A longer waiting interval between the end of neoadjuvant chemoradiotherapy and surgery may increase the rate of pathological complete response in rectal cancer.  
medscape.com
over 3 years ago
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CAM Use May Delay Chemotherapy in Breast Cancer

Breast cancer patients with early-stage disease who use dietary supplements are less likely to initiate recommended chemotherapy, new research shows.  
medscape.com
over 3 years ago