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Chemotherapy near the end of life

Even as cancer treatments become more effective, we can still wonder about the symbolic meaning behind decisions to pursue chemotherapy near the end of life. Although most patients with metastatic cancer choose to receive palliative chemotherapy, evidence suggests that most do not clearly understand its intent.1 In decision making about chemotherapy, doctors are supposed to describe, and patients are supposed to understand, the direct outcomes of the proposed treatment (for example, clinical response rates and side effects). However, the broader implications of such decisions can be just as important. In the linked paper by Wright and colleagues (doi:10.1136/bmj.g1219),2 choosing palliative chemotherapy was associated with a whole set of outcomes that may not have been known, expected, or discussed by patients, their family caregivers, and their oncologists.  
bmj.com
over 5 years ago
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1
30

Should doctors prescribe cannabinoids?

The medical use of cannabis was advocated in the United States in the 1970s and 1980s when clinical trials of oral synthetic tetrahydrocannabinol (THC) and other oral synthetic cannabinoids reported efficacy in controlling nausea in patients with cancer who were undergoing chemotherapy.1 Dronabinol (an oral synthetic THC) was approved by the Food and Drug Administration in 1985 for this indication,1 but it was not widely used because patients were unable to titrate doses or disliked its psychoactive effects.1 It is still available in the US, United Kingdom, and the rest of Europe.  
www.bmj.com
over 5 years ago
Www.bmj
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22

Should doctors prescribe cannabinoids?

The medical use of cannabis was advocated in the United States in the 1970s and 1980s when clinical trials of oral synthetic tetrahydrocannabinol (THC) and other oral synthetic cannabinoids reported efficacy in controlling nausea in patients with cancer who were undergoing chemotherapy.1 Dronabinol (an oral synthetic THC) was approved by the Food and Drug Administration in 1985 for this indication,1 but it was not widely used because patients were unable to titrate doses or disliked its psychoactive effects.1 It is still available in the US, United Kingdom, and the rest of Europe.  
bmj.com
over 5 years ago
Preview
1
16

Should doctors prescribe cannabinoids?

The medical use of cannabis was advocated in the United States in the 1970s and 1980s when clinical trials of oral synthetic tetrahydrocannabinol (THC) and other oral synthetic cannabinoids reported efficacy in controlling nausea in patients with cancer who were undergoing chemotherapy.1 Dronabinol (an oral synthetic THC) was approved by the Food and Drug Administration in 1985 for this indication,1 but it was not widely used because patients were unable to titrate doses or disliked its psychoactive effects.1 It is still available in the US, United Kingdom, and the rest of Europe.  
www.bmj.com
over 5 years ago
Www.bmj
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Chemotherapy near end of life is linked with greater emergency intervention

Patients who are terminally ill with cancer who have chemotherapy in the last months of life are more likely to undergo resuscitation and die in an intensive care unit than in a hospice or at home, a study has found.  
bmj.com
over 5 years ago
Www.bmj
1
19

Should doctors prescribe cannabinoids?

The medical use of cannabis was advocated in the United States in the 1970s and 1980s when clinical trials of oral synthetic tetrahydrocannabinol (THC) and other oral synthetic cannabinoids reported efficacy in controlling nausea in patients with cancer who were undergoing chemotherapy.1 Dronabinol (an oral synthetic THC) was approved by the Food and Drug Administration in 1985 for this indication,1 but it was not widely used because patients were unable to titrate doses or disliked its psychoactive effects.1 It is still available in the US, United Kingdom, and the rest of Europe.  
bmj.com
over 5 years ago
Www.bmj
1
20

Should doctors prescribe cannabinoids?

The medical use of cannabis was advocated in the United States in the 1970s and 1980s when clinical trials of oral synthetic tetrahydrocannabinol (THC) and other oral synthetic cannabinoids reported efficacy in controlling nausea in patients with cancer who were undergoing chemotherapy.1 Dronabinol (an oral synthetic THC) was approved by the Food and Drug Administration in 1985 for this indication,1 but it was not widely used because patients were unable to titrate doses or disliked its psychoactive effects.1 It is still available in the US, United Kingdom, and the rest of Europe.  
bmj.com
over 5 years ago
Preview
1
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Big Pharma, my cancer patient and me | Ranjana Srivastava

Ranjana Srivastava: My patient was refused compassionate access to a cheap chemotherapy. Why? Because pharmaceutical companies are often guilty of selling an ethically murky kind of hope  
the Guardian
over 5 years ago
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Leukemia treatment

There are three main solutions to treat leukemia. Chemotherapy is a collection of drugs which target cells that rapidly multiply (a key characteristic in can...  
YouTube
over 5 years ago
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Quizlet QWait('dom',function(){document.getElementById('PrintLogo').setAttribute('src',"https://quizlet.com/a/i/global/logo_print.du83.png")});

Vocabulary words for Pharmacy Pharmacotherapy Cardiology Atrial Fib Arrhythmia. Includes studying games and tools such as flashcards.  
quizlet.com
about 5 years ago
Www.bmj
1
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Urinary incontinence in women

Urinary incontinence affects women of all ages. History, physical examination, and certain tests can guide specialists in diagnosing stress urinary incontinence, urgency urinary incontinence, and mixed urinary incontinence. First line management includes lifestyle and behavior modification, as well as pelvic floor strength and bladder training. Drug therapy is helpful in the treatment of urgency incontinence that does not respond to conservative measures. In addition, sacral neuromodulation, intravesical onabotulinumtoxinA injections, and posterior tibial nerve stimulation can be used in select patient populations with drug refractory urgency incontinence. Midurethral synthetic slings, including retropubic and transobturator approaches, are safe and efficacious surgical options for stress urinary incontinence and have replaced more invasive bladder neck slings that use autologous or cadaveric fascia. Despite controversy surrounding vaginal mesh for prolapse, synthetic slings for the treatment of stress urinary incontinence are considered safe and minimally invasive.  
bmj.com
about 5 years ago
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Rationally Coping With High Blood Pressure or Hypertension

Rationally Coping, High Blood Pressure, Multifaceted Menace, Hypertension, Silent Killer, HBP, Blood Pressure, BP, Lifestyle Changes, DASH, medicines  
adidarwinian
almost 5 years ago
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1
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Ashya King 'not receiving chemotherapy' - BBC News

The hospital in Prague which treated Ashya King, the young boy recovering from a brain tumour, confirms he has received no chemotherapy - an important part of his original treatment plan.  
BBC News
almost 5 years ago
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Molecular Pathology of Lung Cancer

As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.  
Google Books
over 4 years ago
Www.bmj
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Guidelines, polypharmacy, and drug-drug interactions in patients with multimorbidity

Polypharmacy, defined as the chronic co-prescription of several drugs, is often the consequence of the application of disease specific guidelines, targeting disease specific goals, to patients with multiple chronic diseases. One common consequence of polypharmacy is the high rate of adverse drug reactions, mainly from drug-drug interactions (the ability of a drug to modify the action or effect of another drug administered successively or simultaneously).1 The risk of a drug-drug interaction in any particular patient increases with the number of co-existing diseases and the number of drugs prescribed.2  
bmj.com
over 4 years ago
Www.bmj
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Guidelines, polypharmacy, and drug-drug interactions in patients with multimorbidity

Polypharmacy, defined as the chronic co-prescription of several drugs, is often the consequence of the application of disease specific guidelines, targeting disease specific goals, to patients with multiple chronic diseases. One common consequence of polypharmacy is the high rate of adverse drug reactions, mainly from drug-drug interactions (the ability of a drug to modify the action or effect of another drug administered successively or simultaneously).1 The risk of a drug-drug interaction in any particular patient increases with the number of co-existing diseases and the number of drugs prescribed.2  
bmj.com
over 4 years ago
Www.bmj
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A rash in a patient with neutropenia

A 72 year old man with relapsed acute myeloid leukaemia developed a rash seven days after starting a combined chemotherapy regimen (fludarabine, cytarabine, granulocyte colony stimulating factor, and idarubicin). He first noticed a painful lesion on his left forefoot, and over the next seven days he developed similar lesions on the left lower limb (fig 1⇓), right thigh, and face. He was referred for a dermatological opinion on day 14.  
bmj.com
over 4 years ago
Www.bmj
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Another patient with low back pain

A 52 year old man was admitted to our oncology unit owing to the side effects of ongoing chemotherapy; he also gave a 10 day history of back pain. In 2008, after a bowel resection for colonic obstruction, he had been diagnosed with diffuse large B cell lymphoma. This was treated with eight cycles of R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone) and a complete response was achieved.  
bmj.com
over 4 years ago
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Goserelin reduces ovarian failure associated with breast cancer chemotherapy, study shows

Treating women with the gonadotrophin releasing hormone agonist goserelin during chemotherapy for breast cancer significantly reduced the subsequent risk of ovarian failure and improved fertility, an international randomised trial reported in the New England Journal of Medicine has shown.1  
bmj.com
over 4 years ago