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Concurrent chemoradiation treatment at high-volume facilities improves survival for NSCLC

Patients treated with definitive concurrent chemotherapy and radiation therapy (CCRT) for stage III non-small cell lung cancer (NSCLC) have longer overall survival when treated by highly...  
medicalnewstoday.com
over 4 years ago
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Avoiding Resuscitation Medication Errors - Part I

I am joined by Bryan Hayes to discuss the avoidance of critical medication errors during resuscitations.  
emcrit.org
over 4 years ago
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9

Cancer vaccines

Cancer vaccines are designed to promote tumor specific immune responses, particularly cytotoxic CD8 positive T cells that are specific to tumor antigens. The earliest vaccines, which were developed in 1994-95, tested non-mutated, shared tumor associated antigens that had been shown to be immunogenic and capable of inducing clinical responses in a minority of people with late stage cancer. Technological developments in the past few years have enabled the investigation of vaccines that target mutated antigens that are patient specific. Several platforms for cancer vaccination are being tested, including peptides, proteins, antigen presenting cells, tumor cells, and viral vectors. Standard of care treatments, such as surgery and ablation, chemotherapy, and radiotherapy, can also induce antitumor immunity, thereby having cancer vaccine effects. The monitoring of patients’ immune responses at baseline and after standard of care treatment is shedding light on immune biomarkers. Combination therapies are being tested in clinical trials and are likely to be the best approach to improving patient outcomes.  
feeds.bmj.com
over 4 years ago
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Cancer vaccines

Cancer vaccines are designed to promote tumor specific immune responses, particularly cytotoxic CD8 positive T cells that are specific to tumor antigens. The earliest vaccines, which were developed in 1994-95, tested non-mutated, shared tumor associated antigens that had been shown to be immunogenic and capable of inducing clinical responses in a minority of people with late stage cancer. Technological developments in the past few years have enabled the investigation of vaccines that target mutated antigens that are patient specific. Several platforms for cancer vaccination are being tested, including peptides, proteins, antigen presenting cells, tumor cells, and viral vectors. Standard of care treatments, such as surgery and ablation, chemotherapy, and radiotherapy, can also induce antitumor immunity, thereby having cancer vaccine effects. The monitoring of patients’ immune responses at baseline and after standard of care treatment is shedding light on immune biomarkers. Combination therapies are being tested in clinical trials and are likely to be the best approach to improving patient outcomes.  
feeds.bmj.com
over 4 years ago
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WHAT IS DENTAL ONCOLOGY? — Something to Sink Your Teeth Into

Dental Oncology is an area of dentistry focusing on the dental and oral manifestations of chemotherapy, radiation therap…  
medium.com
over 4 years ago
Www.bmj
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PET after chemotherapy identifies Hodgkin’s lymphoma patients who can avoid radiotherapy

Positron emission tomography (PET) scanning immediately after chemotherapy for Hodgkin’s lymphoma can identify patients who are likely to have good survival without radiotherapy, a study reported in the New England Journal of Medicine has found.1  
feeds.bmj.com
over 4 years ago
Identrx
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IdentRx Promises to Prevent Nearly All Medication Errors |

Medication errors continue to plague the clinical community and even rare cases of mistakes can make a big splash in the news. And for a good reason: we al  
medgadget.com
over 4 years ago
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Prostate cancer drug 'extends lives' - BBC News

A chemotherapy drug can extend the lives of patients with advanced prostate cancer by nearly two years, a major "game-changing" study shows.  
bbc.co.uk
over 4 years ago
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'Prostate cancer drug Docetaxel extended my life' - BBC News

Early treatment with a chemotherapy drug, Docetaxel, extends the lives of patients with advanced prostate cancer by nearly two years, a major study shows.  
bbc.co.uk
over 4 years ago
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15

Hormone replacement therapy (HRT) - NHS Choices

Hormone replacement therapy (HRT) is a treatment used to relieve symptoms of the menopause. It replaces female hormones that are at a lower level as you approach the menopause.  
nhs.uk
over 4 years ago
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Hormone replacement therapy (HRT) - Side effects - NHS Choices

Both of the hormones that are used in hormone replacement therapy (HRT), oestrogen and progestogen, have side effects.  
nhs.uk
over 4 years ago
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Cost-effectiveness of hormone replacement therapy for menopausal symptoms in the UK

This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn.  
crd.york.ac.uk
over 4 years ago
Www.bmj
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Overdiagnosis of bone fragility in the quest to prevent hip fracture

Despite widespread endorsement, Teppo Järvinen and colleagues argue that evidence for stratifying risk of fracture and subsequent drug therapy to prevent hip fracture is insufficient to warrant our current approach  
feeds.bmj.com
over 4 years ago
Www.bmj
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Overdiagnosis of bone fragility in the quest to prevent hip fracture

Despite widespread endorsement, Teppo Järvinen and colleagues argue that evidence for stratifying risk of fracture and subsequent drug therapy to prevent hip fracture is insufficient to warrant our current approach  
feeds.bmj.com
over 4 years ago
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Taxane-containing regimens for metastatic breast cancer | Cochrane

We reviewed the evidence about the effect of taxane-containing chemotherapy regimens in women with metastatic breast cancer. This is an update of a Cochrane review first published in 2003.  
cochrane.org
over 4 years ago
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Idarubicin for treatment of newly diagnosed acute myeloid leukaemia | Cochrane

Acute myeloid leukaemia (AML) is a type of cancer that mainly affects bone marrow and peripheral blood. Although 40% to 45% of AML patients enjoy long-term disease-free survival, most patients will die of the disease. Induction therapy is the first phase of treatment of newly diagnosed AML which is essential for prolonging survival. An anthracycline (a class of chemotherapy drugs derived from the Streptomyces bacterium Streptomyces peucetius var. caesius) combined with cytarabine (a chemotherapy drug used mainly in treatment of haematological malignancies) has remained the standard of induction therapy for several decades. Nowadays there are several kinds of anthracyclines available, among which idarubicin (IDA) draws more attention because of its theoretical advantages in improving efficacy and reducing side effects. However, clinical trials comparing IDA with other anthracyclines have conflicting results.  
cochrane.org
over 4 years ago
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Antibiotic prophylaxis during the second and third trimester in pregnancy to reduce adverse pregnancy outcomes and morbidity | Cochrane

Antibiotics are administered to pregnant women during the second and third trimester of pregnancy (before labour) to prevent bacteria in the vagina and cervix affecting the pregnancy. Infection by some infectious organisms in a woman’s genital tract can cause health problems for the mother and her baby, and has been associated with preterm births. This review of eight randomised trials involved approximately 4300 women in their second or third trimester. We found that antibiotics did not reduce the risk of preterm prelabour rupture of the membranes (one trial, low quality of evidence), or the risk of preterm birth (six trials, high quality of evidence). Preterm delivery was reduced in pregnant women who had a previous preterm birth and an imbalance of bacteria in the vagina (bacterial vaginosis) during the current pregnancy. There was no reduction in preterm delivery in pregnant women with previous preterm birth without a bacterial imbalance during the current pregnancy (two trials). Postpartum endometritis, or infection of the uterus following birth, was reduced overall (three trials, moderate quality of evidence), as well as in a trial of high-risk women who had a previous preterm birth (one trial, moderate quality of evidence). No reduction in neonatal illness was observed. Outcomes of interest were available in trials with high losses to follow-up. We could not estimate the side effects of antibiotics since side effects were rare; however, antibiotics may still have serious side effects on women and their babies.  
cochrane.org
over 4 years ago
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Lab-on-a-Chip Simulates Heartbeat for Testing New Drug Therapies (VIDEO) |

Our hearts evolved to pump blood in a pulsing manner. The heartbeat that nearly the entire body experiences may be important for a variety of biological pr  
medgadget.com
over 4 years ago
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Propofol versus thiopental sodium for the treatment of refractory status epilepticus (RSE) | Cochrane

Persistent convulsions (lasting 30 minutes or more) are a major medical emergency associated with significant morbidity and mortality. At times, these convulsions fail to respond to first- and second-line drug therapy and may occur in up to 31% of patients suffering from persistent seizure or convulsive activities. Persistent seizure activity may become unresponsive to antiepileptic drugs. Anaesthetics such as thiopental sodium and propofol are frequently given for control of seizures in such situations. Both agents have their own side effects and complications. This review evaluates the evidence for the use of these anaesthetic drugs in controlling seizure activity in patients with RSE.  
cochrane.org
about 4 years ago
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Drug therapy for treating systemic intravascular activation of coagulation in patients with leukemia | Cochrane

Review question We reviewed the clinical benefits and harms of anticoagulant and antifibrinolytic therapy for treating disseminated intravascular coagulation (DIC) in patients with acute or chronic leukemia.  
cochrane.org
about 4 years ago