Endocrinology

Here is a simplified pathway of glucose processing on entering the hepatocyte. The synthesis of cholesterol in the liver is insulin dependent. Glycogenesis is also insulin dependent however the interaction has not been drawn on here. The pathogenesis of metabolic syndrome is complex, but appears to be underpinned by insulin resistance within the liver. Metformin and Statins also act directly and indirectly to reduce cholesterol synthesis. Both of which (logically) form a crucial part in the treatment of metabolic syndrome.  

Type 2 diabetes is a complex systems disease, caused by interactions between lifestyle and genes. It is an illusion to believe that it can be cured by medication. Lifestyle change should always be at the heart of treatment.  

By Amy Podmolik, RD, CDE Type 2 diabetes risk factors. Metabolic syndrome. Insulin Resistance. The Role Of Exercise. Eating with Intent.  

How do patients with adrenal insufficiency feel about glucocorticoid therapy -- and how common is the problem of non-adherence?  

An unrestricted calorie Mediterranean diet enriched with healthy vegetable fats does not increase weight gain or waist circumference more than a low fat diet, a five year study published in The Lancet Diabetes and Endocrinology has suggested, bolstering the argument that total fat content is not a useful measure of harms or benefits of food.1  

An unrestricted calorie Mediterranean diet enriched with healthy vegetable fats does not increase weight gain or waist circumference more than a low fat diet, a five year study published in The Lancet Diabetes and Endocrinology has suggested, bolstering the argument that total fat content is not a useful measure of harms or benefits of food.1  

An unrestricted calorie Mediterranean diet enriched with healthy vegetable fats does not increase weight gain or waist circumference more than a low fat diet, a five year study published in The Lancet Diabetes and Endocrinology has suggested, bolstering the argument that total fat content is not a useful measure of harms or benefits of food.1  

Toxicities with cisplatin-based regimens may be overcome with carboplatin.  

Progress is being made in the treatment of the 'ruthless dictator of all cancers.'  

African-American women who reported regular use of body power were at greater risk for ovarian cancer compared to their peers who didn't use talc, a new study shows.  

A new combination of chemotherapy drugs should become the main therapy for pancreatic cancer, say UK researchers.  

A review of data from 19 studies and the author's own patient population suggest an overinterpretation of the RAS mutation as malignant in cytologically indeterminate thyroid nodules.  

Can programs such as Weight Watchers reduce weight among persons with prediabetes as effectively as an individual counseling program?  

Measuring hCG levels in pregnant women helps identify those at risk of preeclampsia due to underlying abnormal thyroid function rather than simply pregnancy-raised thyroid activity.  

A systematic review and meta-analysis find association, but the mechanism isn't clear, and no randomized clinical trials of supplementation have been conducted as yet.  

Everything you need to know about Increased Prolactin.  

The advice is similar to that in the 2015 American Thyroid Association guidance but focuses on thyroid nodules (excluding cancer) and uses a simpler classification scheme to determine biopsy need.  

Diagnostic molecular testing of thyroid nodules did not significantly affect decision-making in thyroid surgery and may even have led to some overtreatment in a recent trial.  

Dr Charles C. Wykoff reviews recent data showing that more timely treatment has a significant upside.  

Overview and concise explanation of syndrome of inappropriate antidiuretic hormone (SIADH)