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GeneExpression

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Protein translation 2

Visit us (http://www.khanacademy.org/science/healthcare-and-medicine) for health and medicine content or (http://www.khanacademy.org/test-prep/mcat) for MCAT...  
YouTube
about 5 years ago
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11

Protein Translation 1

Visit us (http://www.khanacademy.org/science/healthcare-and-medicine) for health and medicine content or (http://www.khanacademy.org/test-prep/mcat) for MCAT...  
YouTube
about 5 years ago
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37

Gene Expression

Gene Expression At http://bergmanchiropractic.com and http://Owners-Guide.com we strive to educate people on natural solutions to health. -------------------...  
youtube.com
over 4 years ago
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TSRI scientists find molecular trigger of schizophrenia-like behaviors and brain changes

Scientists at The Scripps Research Institute (TSRI) have identified a molecule in the brain that triggers schizophrenia-like behaviors, brain changes and global gene expression in an animal...  
medicalnewstoday.com
over 4 years ago
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Gene signatures predict doxorubicin response in K9 osteosarcoma

COXEN gene expression model matches dogs with bone cancer to most effective drugThere are two chemotherapies commonly used to treat bone cancer in dogs: doxorubicin and...  
medicalnewstoday.com
over 4 years ago
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Scientists discover drug that benefits offspring of mice with Huntington's

A new study from scientists at The Scripps Research Institute suggests therapies that change gene expression in parents can help their children and generations to come.  
medicalnewstoday.com
over 4 years ago
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2

Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth

Cell growth is orchestrated by changes in gene expression that respond to developmental and environmental cues. Among the signaling pathways that direct growth are enzymes of the protein kinase C (PKC) family, which are ubiquitous proteins belonging to three distinct subclasses: conventional PKCs, novel PKCs, and atypical PKCs. Functional overlap makes determining the physiological actions of different PKC isoforms difficult. We showed that two novel PKC isoforms, PKCδ and PKCε, redundantly govern stress-reactive and developmental heart growth by modulating the expression of cardiac genes central to stress-activated protein kinase and periostin signaling. Mice with combined postnatal cardiomyocyte-specific genetic ablation of PKCδ and germline deletion of PKCε (DCKO) had normally sized hearts, but their hearts had transcriptional changes typical of pathological hypertrophy. Cardiac hypertrophy and dysfunction induced by hemodynamic overloading were greater in DCKO mice than in mice with a single deletion of either PKCδ or PKCε. Furthermore, gene expression analysis of the hearts of DCKO mice revealed transcriptional derepression of the genes encoding the kinase ERK (extracellular signal–regulated kinase) and periostin. Mice with combined embryonic ablation of PKCδ and PKCε showed enhanced growth and cardiomyocyte hyperplasia that induced pathological ventricular stiffening and early lethality, phenotypes absent in mice with a single deletion of PKCδ or PKCε. Our results indicate that novel PKCs provide retrograde feedback inhibition of growth signaling pathways central to cardiac development and stress adaptation. These growth-suppressing effects of novel PKCs have implications for therapeutic inhibition of PKCs in cancer, heart, and other diseases.  
stke.sciencemag.org
over 4 years ago
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Can blocking gene expression prevent a heart disease?

Blocking the expression of a gene may help prevent illnesses linked to excessive fat in blood such as cardiovascular and pancreatic diseases, says a new study.The researchers found that shutting down - Can blocking gene expression prevent a heart disease?  
thehealthsite.com
over 4 years ago
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Gene Expression Classifier Test Does Not Change Thyroid Surgery Decisions

Gene expression classifier (GEC) molecular testing does not alter surgical decisions for most patients with thyroid nodules, researchers report.  
medscape.com
almost 4 years ago
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Brain BDNF Expression May Explain Cognitive Reserve

Boosting BDNF gene expression might be a good therapeutic strategy to prevent Alzheimer's disease, researchers speculate.  
medscape.com
almost 4 years ago