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Precision Medicine Needs 'Precision Genomics'

In half of all cancer patients, tumor-only gene sequencing is not enough to guide therapeutic decisions on the use of precision cancer agents.  
medscape.com
about 5 years ago
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Gigantic Data and Genomics

Pat Salber (@docweighsin) chats with Oracle's Jonathan Sheldon (Global VP for Health Care) about meeting the data demands of Precision Medicine. He says that...  
youtube.com
about 5 years ago
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Gigantic Data and Genomics - YouTube

Pat Salber (@docweighsin) chats with Oracle's Jonathan Sheldon (Global VP for Health Care) about meeting the data demands of Precision Medicine. He says that...  
youtube.com
about 5 years ago
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83

A Conversation with Oxford's Peter Donnelly: Genomics and Personalized Medicine

The TDWI/Hatch team had good fortune to attend the amazing Personalized Medicine World Conference put on by Tal and Gadi Behar at the Computer History Museum...  
youtube.com
about 5 years ago
Www.bmj
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The role of pathogen genomics in assessing disease transmission

Whole genome sequencing (WGS) of pathogens enables the sources and patterns of transmission to be identified during specific disease outbreaks and promises to transform epidemiological research on communicable diseases. This review discusses new insights into disease spread and transmission that have come from the use of WGS, particularly when combined with genomic scale phylogenetic analyses. These include elucidation of the mechanisms of cross species transmission, the potential modes of pathogen transmission, and which people in the population contribute most to transmission. Particular attention is paid to the ability of WGS to resolve individual patient to patient transmission events. Importantly, WGS data seem to be sufficiently discriminatory to target cases linked to community or hospital contacts and hence prevent further spread, and to investigate genetically related cases without a clear epidemiological link. Approaches to combine evidence from epidemiological with genomic sequencing observations are summarised. Ongoing genomic surveillance can identify determinants of transmission, monitor pathogen evolution and adaptation, ensure the accurate and timely diagnosis of infections with epidemic potential, and refine strategies for their control.  
feeds.bmj.com
about 5 years ago
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17

The role of pathogen genomics in assessing disease transmission

Whole genome sequencing (WGS) of pathogens enables the sources and patterns of transmission to be identified during specific disease outbreaks and promises to transform epidemiological research on communicable diseases. This review discusses new insights into disease spread and transmission that have come from the use of WGS, particularly when combined with genomic scale phylogenetic analyses. These include elucidation of the mechanisms of cross species transmission, the potential modes of pathogen transmission, and which people in the population contribute most to transmission. Particular attention is paid to the ability of WGS to resolve individual patient to patient transmission events. Importantly, WGS data seem to be sufficiently discriminatory to target cases linked to community or hospital contacts and hence prevent further spread, and to investigate genetically related cases without a clear epidemiological link. Approaches to combine evidence from epidemiological with genomic sequencing observations are summarised. Ongoing genomic surveillance can identify determinants of transmission, monitor pathogen evolution and adaptation, ensure the accurate and timely diagnosis of infections with epidemic potential, and refine strategies for their control.  
feeds.bmj.com
about 5 years ago
Www.bmj
0
5

Diagnosis and treatment of cancer using genomics

The field of cancer diagnostics is in constant flux as a result of the rapid discovery of new genes associated with cancer, improvements in laboratory techniques for identifying disease causing events, and novel analytic methods that enable the integration of many different types of data. These advances have helped in the identification of novel, informative biomarkers. As more whole genome sequence data are generated and analyzed, emerging information on the baseline variability of the human genome has shown the importance of the ancestral genomic background in patients with a potential disease causing variant. The recent discovery of many novel DNA sequence variants, advances in sequencing and genomic technology, and improved analytic methods enable the impact of germline and somatic genome variation on tumorigenesis and metastasis to be determined. New molecular targets and companion diagnostics are changing the way geneticists and oncologists think about the causes, diagnosis, and treatment of cancer.  
feeds.bmj.com
almost 5 years ago
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Translational Psychiatry - Functional genomics indicate that schizophrenia may be an adult vascular-ischemic disorder

Translational Psychiatry explores the more translational area between the research in neuroscience and conceptually novel treatments  
nature.com
almost 5 years ago
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152

Epigenetics - An Introduction

This sketch video about epigenetics was created by Armando Hasudungan, in collaboration with Professor Susan Clark and Dr Kate Patterson at the Garvan Instit...  
youtube.com
almost 5 years ago
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14

The Epigenetics of Acute and Chronic Kidney Disease

This new article discusses the emerging field of epigenetic therapy, and the evolving role that it could play in the future treatment of renal disease.  
medscape.com
over 4 years ago
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16

WCLC Presidential Symposium: Summary, Clinical Implications

Dr Gilberto Lopes reviews the four top abstracts from the 16th World Conference on Lung Cancer, including treatments for NSCLC as well as genomics and lung cancer prevention.  
medscape.com
over 4 years ago
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New Clues That Sexual Orientation Could Be Epigenetic

Investigators have developed a preliminary biomarker-based model that predicts the sexual orientation of men.  
medscape.com
over 4 years ago
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Critical Care

Epigenetics is the study of how cells, organs, and even individuals utilize their genes over specific periods of time, and under specific environmental constraints. Very importantly, epigenetics is now expanding into the field of medicine and hence should provide new information for the development of drugs. Bomsztyk and colleagues have detected major epigenetic changes occurring in several organs as early as 6 h after the onset of a mouse model of multiple organ dysfunction syndrome induced by Staphylococcus aureus lung injury. Decrease in mRNA of key genes involved in endothelial function was found to be associated with (and potentially explained by) a decrease in permissive histone marks, while repressive marks were unchanged. We discuss here the limitations of a whole-organ as opposed to a cell-specific approach, the nature of the controls that were chosen, and the pitfalls of histone modifications as a cause of the eventual phenotype. While the use of ‘epidrugs’ is definitely welcome in the clinic, how and when they will be used in sepsis-related multiple organ dysfunction will require further experimental studies.  
ccforum.com
over 4 years ago
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First Clinical Single Molecule Genome Sequencer Unveiled |

According to claims by Direct Genomics, a Chinese firm, it is introducing the first single molecule DNA sequencer for clinical use that does not require an  
medgadget.com
over 4 years ago
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Former Duke University oncologist is guilty of research misconduct, US officials find

A cancer genomics researcher, whose reported findings appeared in some of the world’s most prestigious journals and prompted the initiation of several clinical trials, has been found guilty of research misconduct by the US Department of Health and Human Services’ Office of Research Integrity (ORI).  
feeds.bmj.com
over 4 years ago
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Exponential Medicine 2015 Day 1: Genomics, Big Data, AI, and Bitcoin? |

Welcome back for Medgadget's coverage of Exponential Medicine in San Diego, CA, a Singularity University event. Exponential Medicine promises four days of  
medgadget.com
over 4 years ago
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Huge Cancer Research Fraud, But Only One Doc Blamed

Why has only one researcher has been punished for the false research in cancer genomics at Duke University that led to clinical trials in hundreds of patients?  
medscape.com
over 4 years ago