New to Meducation?
Sign up
Already signed up? Log In

Category

Preview
0
8

Hormonal birth control and fracture risk in observational studies | Cochrane

When bone mass declines with age, the risk of fractures increases. Birth control methods that have hormones may lead to changes in women’s bone density. Worry about fractures may limit the use of these effective methods. Observational studies can collect data on birth control use as well as fractures later in life. Through June 2015, we searched for such studies in several databases.   
cochrane.org
over 4 years ago
Www.bmj
0
13

The safety of incretin based drugs

Important concerns have been raised about the impact of incretin based drugs on the risk of acute pancreatitis in patients with type 2 diabetes. Two linked papers by Li and colleagues (doi:10.1136/bmj.g2366) and Faillie and colleagues (doi:10.1136/bmj.g2780) could help us decide whether patients and clinicians should consider these concerns when choosing an antihyperglycemic drug.1 2  
feeds.bmj.com
over 4 years ago
Www.bmj
0
17

Incretin based drugs and risk of acute pancreatitis in patients with type 2 diabetes: cohort study

Objectives To determine whether the use of incretin based drugs, compared with sulfonylureas, is associated with an increased risk of acute pancreatitis.  
feeds.bmj.com
over 4 years ago
Preview
0
0

Methods to reduce pain with insertion of intrauterine contraception | Cochrane

Fear of pain with insertion of intrauterine contraception (IUC) may cause women to avoid using this very effective method of birth control. IUC includes devices with copper and with the hormone levonorgestrel. Researchers have studied many ways of reducing pain with IUC insertion. These include drugs that lessen uterine cramps, soften and open the cervix (uterus opening), or numb the cervix.  
cochrane.org
over 4 years ago
Preview
0
1

Welltwigs Tracks Hormone and Basal Body Temperature to Predict Best Time to Conceive |

A new startup hopes to offer a new option to help women conceive children by timing when best to have sex based on the basal body temperature and the prese  
medgadget.com
over 4 years ago
Preview
0
2

Corticosteroids for treating optic neuritis | Cochrane

Review question We reviewed the evidence about the effects of corticosteroids on visual recovery of people with acute optic neuritis.  
cochrane.org
about 4 years ago
Preview
0
5

The risk of heart attack and stroke in women using birth control pills | Cochrane

Since their introduction, combined oral contraceptive pills have become one of the most popular birth control methods. These pills contain two types of female hormones, estrogen and progestagen. When used correctly, the failure rate (i.e. the occurrence of unwanted pregnancy) is less than one per 100 women per year. Despite their reliability, oral contraceptive pills have been found to increase the risk of a blood clot forming in an artery, i.e. arterial thrombosis (heart attack or stroke). As arterial thrombosis is rare in young women, and as many types of oral contraceptive pills exist, the size of the risk is unclear. Furthermore, the effect of different types of progestagens or different doses of estrogen on the risk of arterial thrombosis is unknown.  
cochrane.org
about 4 years ago
Preview
0
0

Interventions for treating constipation in pregnancy | Cochrane

The term 'constipation' is defined as difficulty in passing stool and reduced frequency of bowel movements. It is characterised by discomfort, excessive straining, hard or lumpy stools, a sensation of incomplete evacuation, and infrequent bowel movements. Constipation is a common symptom experienced during pregnancy. This can result from a combination of factors, including changes in hormones during pregnancy affecting the digestive system, reduced physical activity and changes in dietary habits during pregnancy. In addition, as the baby grows it can press on the mother's intestines and cause digestive delays/obstructions.  
cochrane.org
about 4 years ago
Preview
2
45

Neurotransmitter Receptors Alter Postsynaptic Membrane Permeability - Neuroscience - NCBI Bookshelf

In 1907, the British physiologist John N. Langley introduced the concept of receptor molecules to explain the specific and potent actions of certain chemicals on muscle and nerve cells. Much subsequent work has shown that receptor molecules do indeed account for the ability of neurotransmitters, hormones, and drugs to alter the functional properties of neurons. While it has been clear since Langley's day that receptors are important for synaptic transmission, their identity and detailed mechanism of action remained a mystery until quite recently. It is now known that neurotransmitter receptors are proteins embedded in the plasma membrane of postsynaptic cells. Domains of receptor molecules that extend into the synaptic cleft bind neurotransmitters that are released into this space by the presynaptic neuron. The binding of neurotransmitters, either directly or indirectly, causes ion channels in the postsynaptic membrane to open or close (Figure 7.1). Typically, the resulting ion fluxes change the membrane potential of the postsynaptic cell, thus mediating the transfer of information across the synapse. Figure 7.1Receptors that mediate the postsynaptic actions of neurotransmitters have two functions. First, specific binding sites on the extracellular side of receptors allow these proteins to detect the presence of neurotransmitters in the synaptic cleft. Second, transmitter-bound receptors alter the ionic permeability of the postsynaptic membrane by virtue of being coupled, directly or indirectly, to ion channels in the postsynaptic membrane. Opening or closing these channels as a result of transmitter binding allows ionic currents to flow, thus changing the postsynaptic membrane potential.  
ncbi.nlm.nih.gov
about 4 years ago
Preview
0
1

Corticosteroids for bacterial meningitis | Cochrane

We reviewed the evidence about the effect of corticosteroids on mortality, hearing loss and/or neurological sequelae (such as hearing loss, neurologic deficits) in adults and children with acute bacterial meningitis.  
cochrane.org
about 4 years ago
Preview
0
2

Chemohormonal Therapy Effective in Metastatic Prostate Cancer CME/CE

: A randomized study shows that docetaxel from the start, alongside androgen deprivation therapy, improves survival outcomes in a new study of men with advanced hormone-sensitive prostate cancer.  
medscape.org
about 4 years ago
Preview
0
1

Corticosteroids Improve CAP Outcomes CME/CE

: For adult inpatients with community-acquired pneumonia, systemic corticosteroids may lower mortality rates by 3%, the need for mechanical ventilation by 5%, and length of hospital stay by 1 day.  
medscape.org
about 4 years ago
Preview
0
0

Study Suggests Incretin Drugs Don't Cause Pancreatic Cancer

A 7-year Danish population-based study found pancreatic cancer risks elevated for all glucose-lowering agents, not just incretin-based therapies, suggesting that diabetes itself may be the cause.  
medscape.com
about 4 years ago
Preview
0
6

Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies

Objective To investigate the risk of pancreatitis associated with the use of incretin-based treatments in patients with type 2 diabetes mellitus.  
feeds.bmj.com
about 4 years ago
Preview
0
0

Treating Transgender Patients: A Primer

Dr Ranit Mishori discusses transgender patient sensitivity, diagnosis, and treatment, encouraging doctors to ask about more than just hormone use.  
medscape.com
about 4 years ago
Preview
0
0

Critical Care

There is a sex difference in the risk of ischemic acute kidney injury (AKI), and estrogen mediates the protective effect of female sex. We previously demonstrated that preprocedural chronic restoration of physiologic estrogen to ovariectomized female mice ameliorated AKI after cardiac arrest and cardiopulmonary resuscitation (CA/CPR). In the present study, we hypothesized that male mice and aged female mice would benefit from estrogen administration after CA/CPR. We tested the effect of estrogen in a clinically relevant manner by administrating it after CA/CPR.  
ccforum.com
about 4 years ago
Preview
0
23

Fibromyalgia Linked to Deficiencies in RBC Magnesium, IGF-1

A small study shows deficiencies in red blood cell magnesium and insulin-like growth factor 1 in patients with fibromyalgia and reflects growing interest in the role of hormones and endocrine factors in chronic pain.  
medscape.com
about 4 years ago
Preview
0
7

Critical Care

Endotracheal intubation is frequently complicated by laryngeal edema, which may present as postextubation stridor or respiratory difficulty or both. Ultimately, postextubation laryngeal edema may result in respiratory failure with subsequent reintubation. Risk factors for postextubation laryngeal edema include female gender, large tube size, and prolonged intubation. Although patients at low risk for postextubation respiratory insufficiency due to laryngeal edema can be identified by the cuff leak test or laryngeal ultrasound, no reliable test for the identification of high-risk patients is currently available. If applied in a timely manner, intravenous or nebulized corticosteroids can prevent postextubation laryngeal edema; however, the inability to identify high-risk patients prevents the targeted pretreatment of these patients. Therefore, the decision to start corticosteroids should be made on an individual basis and on the basis of the outcome of the cuff leak test and additional risk factors. The preferential treatment of postextubation laryngeal edema consists of intravenous or nebulized corticosteroids combined with nebulized epinephrine, although no data on the optimal treatment algorithm are available. In the presence of respiratory failure, reintubation should be performed without delay. Application of noninvasive ventilation or inhalation of a helium/oxygen mixture is not indicated since it does not improve outcome and increases the delay to intubation.  
ccforum.com
about 4 years ago
Preview
1
3

Synacthen Test. Investigations in to addison's, synacthen. | Patient

A synacthen test checks the function of the adrenal glands. It can help to see whether your body is producing enough steroid hormone (cortisol). Note :...  
patient.info
about 4 years ago