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ImmuneSystem

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Immune Signature May Aid Prognosis, Therapy in Glioblastoma

Researchers have developed a risk 'signature' based on expression of eight immune genes related to glioblastoma, and they believe the immune system could be a target for therapy in this disease.  
medscape.com
about 4 years ago
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Infections in first six months of life show link to type 1 diabetes

Recurrent viral respiratory tract infections in the first six months of life are associated with developing type 1 diabetes, a study published in JAMA has shown.1 The German researchers said their findings suggested that the first half year of life is crucial for the development of the immune system and autoimmunity.  
feeds.bmj.com
over 4 years ago
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Infections in first six months of life show link to type 1 diabetes

Recurrent viral respiratory tract infections in the first six months of life are associated with developing type 1 diabetes, a study published in JAMA has shown.1 The German researchers said their findings suggested that the first half year of life is crucial for the development of the immune system and autoimmunity.  
feeds.bmj.com
over 4 years ago
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Pulmonary nodules in a man with a history of bone marrow transplantation

Our patient was diagnosed as having Philadelphia chromosome positive pre-B acute lymphoblastic leukaemia with lymphoid blast crisis (blast crisis of chronic myeloid leukaemia) in 2011. Treatment with two cycles of hyper-CVAD (alternating cyclophosphamide+vincristine+doxorubicin+dexamethasone with methotrexate+cytarabine) plus dasatinib resulted in a negative bone marrow biopsy (remission). He had an allogeneic peripheral blood stem cell transplant from a 10/10 HLA matched unrelated donor in 2013. Conditioning was with cyclophosphamide and 1200 cGy total body irradiation. Graft versus host disease prophylaxis was with tacrolimus and methotrexate. Dasatinib was continued after his transplant. In late 2013 he developed relapsed acute lymphoblastic leukaemia. He was treated with fludarabine, cytarabine, and granulocyte colony stimulating factor. Bone marrow biopsy after chemotherapy showed persistent acute lymphoblastic leukaemia, even after he was switched to ponatinib and dexamethasone. Daunorubicin and vincristine were added for one cycle but were discontinued when he was admitted to hospital for cellulitis. Bone marrow biopsy was negative but one three months later showed recurrent acute B lymphoblastic leukaemia. Remission occurred after re-induction with clofarabine in the autumn of 2014; this was followed by 6-mercaptopurine, methotrexate, vincristine, and prednisone maintenance therapy.  
feeds.bmj.com
over 4 years ago
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9

Pulmonary nodules in a man with a history of bone marrow transplantation

Our patient was diagnosed as having Philadelphia chromosome positive pre-B acute lymphoblastic leukaemia with lymphoid blast crisis (blast crisis of chronic myeloid leukaemia) in 2011. Treatment with two cycles of hyper-CVAD (alternating cyclophosphamide+vincristine+doxorubicin+dexamethasone with methotrexate+cytarabine) plus dasatinib resulted in a negative bone marrow biopsy (remission). He had an allogeneic peripheral blood stem cell transplant from a 10/10 HLA matched unrelated donor in 2013. Conditioning was with cyclophosphamide and 1200 cGy total body irradiation. Graft versus host disease prophylaxis was with tacrolimus and methotrexate. Dasatinib was continued after his transplant. In late 2013 he developed relapsed acute lymphoblastic leukaemia. He was treated with fludarabine, cytarabine, and granulocyte colony stimulating factor. Bone marrow biopsy after chemotherapy showed persistent acute lymphoblastic leukaemia, even after he was switched to ponatinib and dexamethasone. Daunorubicin and vincristine were added for one cycle but were discontinued when he was admitted to hospital for cellulitis. Bone marrow biopsy was negative but one three months later showed recurrent acute B lymphoblastic leukaemia. Remission occurred after re-induction with clofarabine in the autumn of 2014; this was followed by 6-mercaptopurine, methotrexate, vincristine, and prednisone maintenance therapy.  
feeds.bmj.com
over 4 years ago
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8

Pulmonary nodules in a man with a history of bone marrow transplantation

Our patient was diagnosed as having Philadelphia chromosome positive pre-B acute lymphoblastic leukaemia with lymphoid blast crisis (blast crisis of chronic myeloid leukaemia) in 2011. Treatment with two cycles of hyper-CVAD (alternating cyclophosphamide+vincristine+doxorubicin+dexamethasone with methotrexate+cytarabine) plus dasatinib resulted in a negative bone marrow biopsy (remission). He had an allogeneic peripheral blood stem cell transplant from a 10/10 HLA matched unrelated donor in 2013. Conditioning was with cyclophosphamide and 1200 cGy total body irradiation. Graft versus host disease prophylaxis was with tacrolimus and methotrexate. Dasatinib was continued after his transplant. In late 2013 he developed relapsed acute lymphoblastic leukaemia. He was treated with fludarabine, cytarabine, and granulocyte colony stimulating factor. Bone marrow biopsy after chemotherapy showed persistent acute lymphoblastic leukaemia, even after he was switched to ponatinib and dexamethasone. Daunorubicin and vincristine were added for one cycle but were discontinued when he was admitted to hospital for cellulitis. Bone marrow biopsy was negative but one three months later showed recurrent acute B lymphoblastic leukaemia. Remission occurred after re-induction with clofarabine in the autumn of 2014; this was followed by 6-mercaptopurine, methotrexate, vincristine, and prednisone maintenance therapy.  
feeds.bmj.com
over 4 years ago
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0
7

Pulmonary nodules in a man with a history of bone marrow transplantation

Our patient was diagnosed as having Philadelphia chromosome positive pre-B acute lymphoblastic leukaemia with lymphoid blast crisis (blast crisis of chronic myeloid leukaemia) in 2011. Treatment with two cycles of hyper-CVAD (alternating cyclophosphamide+vincristine+doxorubicin+dexamethasone with methotrexate+cytarabine) plus dasatinib resulted in a negative bone marrow biopsy (remission). He had an allogeneic peripheral blood stem cell transplant from a 10/10 HLA matched unrelated donor in 2013. Conditioning was with cyclophosphamide and 1200 cGy total body irradiation. Graft versus host disease prophylaxis was with tacrolimus and methotrexate. Dasatinib was continued after his transplant. In late 2013 he developed relapsed acute lymphoblastic leukaemia. He was treated with fludarabine, cytarabine, and granulocyte colony stimulating factor. Bone marrow biopsy after chemotherapy showed persistent acute lymphoblastic leukaemia, even after he was switched to ponatinib and dexamethasone. Daunorubicin and vincristine were added for one cycle but were discontinued when he was admitted to hospital for cellulitis. Bone marrow biopsy was negative but one three months later showed recurrent acute B lymphoblastic leukaemia. Remission occurred after re-induction with clofarabine in the autumn of 2014; this was followed by 6-mercaptopurine, methotrexate, vincristine, and prednisone maintenance therapy.  
feeds.bmj.com
over 4 years ago
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Final piece of type 1 diabetes puzzle solved - BBC News

A complete picture of what the immune system attacks to cause type 1 diabetes is revealed by scientists.  
bbc.co.uk
over 4 years ago
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MRI, Macrophages Help Predict Prognosis in Glioblastoma

For patients with glioblastoma multiforme, combining MRI tumor features with cancer-associated macrophage status could allow clinicians to more accurately predict outcomes.  
medscape.com
over 4 years ago
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Head and neck cancer drug 'game changer' - BBC News

A new type of cancer drug that wakes up the patient's own immune system to fight tumours could be a game changer for tackling head and neck cancers, say experts.  
bbc.co.uk
over 4 years ago
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Gene editing 'boosts' cancer-killing cells - BBC News

Cancer scientists have genetically modified the immune system to help them attack tumours in mice.  
bbc.co.uk
over 4 years ago
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Acquired Immunity

Acquired (adaptive or specific) immunity is not present at birth. It is learned. As a person’s immune system encounters foreign substances (antigens), the components of acquired immunity learn the best way to attack each antigen and begin to develop a memory for that antigen. Acquired immunity is also called specific immunity because it tailors its attack to a specific antigen previously encountered. Its hallmarks are its ability to learn, adapt, and remember.  
merckmanuals.com
over 4 years ago
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Immunotherapy: T-Cell Engaging Antibodies and Immune Checkpoint Blockade CME/CE

: Dr Gore reviews clinical examples of how antibodies harness the immune system to fight cancer  
medscape.org
over 4 years ago
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Immune Activation in the Course of HIV-1 Infection

What factors are responsible for the global activation of the immune system observed in HIV-1 infected patients?  
medscape.com
over 4 years ago
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Scientists 'find cancer's Achilles heel' - BBC News

Scientists from University College, London believe they have discovered a way to "steer" the immune system to kill cancers.  
bbc.co.uk
over 4 years ago
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'Releasing the Dogs’ in the Body’s War on Cancer

Drs Lou Weiner and Chris Heery vividly describe strategies that prompt the immune system to attack and kill cancer cells, and offer a view from the trenches of cancer immunotherapy.  
medscape.com
over 4 years ago
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White blood cell found in birds 'can destroy fatal infection' - BBC News

A specialised white blood cell found in birds can destroy an infection which is thought to cause thousands of deaths a year worldwide, scientists claim.  
bbc.co.uk
over 4 years ago
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Excitement at new cancer treatment - BBC News

A therapy that retrains the body's immune system to fight cancer has provoked excitement after more than 90% of terminally ill patients entered remission.  
bbc.co.uk
over 4 years ago
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Breakthrough for Diabetes: Material Protects Transplanted Pancreatic Islet Cells from Immune System |

Glucose-stimulated insulin-producing cells, derived from stem cells, are protected inside capsules that are engineered to be invisible to the host immune s  
medgadget.com
over 4 years ago