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ImmuneSystem

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Johns Hopkins Lupus Center

Antibodies form in the body as a response to infection. When an invader (antigen) enters the body, white blood cells known as B lymphocytes react by making special types of proteins called antibodies. Antibodies are your body’s way of remembering an antigen; if it enters the body again, the antibodies will recognize it, combine with it, and neutralize it to prevent you from becoming infected. However, with autoimmune diseases such as lupus, the immune system can produce antibodies (auto-antibodies) that attack your body’s cells as though they were invaders, causing inflammation, damage, and even destruction. Several blood tests can be performed to detect specific auto-antibodies and help make the diagnosis of lupus. These blood tests are not conclusive by themselves, but combining the tests with certain physical findings can help to corroborate a diagnosis.  
hopkinslupus.org
over 5 years ago
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Virscan, A New Technology to Analyze Virus Attack History from a Single Drop of Blood |

Our immune system develops antibodies to any virus that it encounters, and these antibodies are present in our blood anywhere from years to decades. Resear  
medgadget.com
over 5 years ago
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Asthma and COPD - Pathogenesis and Pathophysiology

A review of the pathology of asthma and COPD, including the role of the immune system, along with the mechanisms behind the hypercapnia and hypoxemia of COPD...  
youtube.com
over 5 years ago
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Critical Care

Since the critical care physician will most likely be involved in a life-threatening expression of systemic mastocytosis, recognition of this disease is of utmost importance in the critical care management of these patients. Mastocytosis is a severely under-recognized disease because it typically occurs secondary to another condition and thus may occur more frequently than assumed. In this article, we will review the current knowledge on the treatment of mastocytosis crises with an emphasis on critical care management. Mastocytosis is characterized by the clonal proliferation and accumulation of mast cells in different tissues. Mast cell mediators contain a wide range of biologically active substances that may lead to itching and hives but may ultimately lead to anaphylactic shock caused by the release of histamine and other mediators from mast cells. The mainstay of therapy is the avoidance of potential triggers of mast cell degranulation and, if unsuccessful, blocking the cascade of mast cell mediators. The critical care physician should be well aware of the special precautions which should be kept in mind throughout the management of a mastocytosis crisis to avoid massive mast cell degranulation. Histamine-releasing drugs and certain physical triggers like temperature change should be avoided.  
ccforum.com
over 5 years ago
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Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis | Cochrane

Review question Are treatments with eye drops of antihistamines and mast cell stabilisers, alone or in combination, effective and safe in people with seasonal and allergic conjunctivitis? The main outcome measure was eye symptoms reported by participants, including eye itching, irritation (burning sensation), watering eyes (tearing), and photophobia (dislike of light). We found 30 trials.  
cochrane.org
over 5 years ago
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The Neuroendocrine Immune Network

This informative publication updates the study of interaction of the nervous and endocrine systems with the immune system in the body. It describes the anatomical basis of these interactions, reviewing the innervation of lymphoid tissue and mast cells. The book discusses the effect of the endocrine system on immune function, including the relation of sex to the immune response. Emphasis is given to opioids, substance P, neurotensin, vasoactive intestinal peptide, somatostatin and cholecystokinin. Also addressed is the immunoregulatory effect of leukotrienes and platelet-activating factors. Scrutinized within are stress as an aspect of neuro-immune interactions, and the central role of the hypothalamus in this context. The book reviews the eye and the gastrointestinal tract with respect to the coordination of the nervous, endocrine, and immune systems in serving these organs. This work is of particular value to those in immunology, endocrinology, gastroenterology, and developmental biology.  
books.google.co.uk
over 5 years ago
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What are the risks of drinking breast milk? - BBC News

One of the authors of a report into the risks of buying unregulated breast milk online, Dr Sarah Steele, says claims it boosts the adult immune system are misleading.  
bbc.co.uk
over 5 years ago
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Severe combined immunodeficiency

Severe combined immunodeficiency (SCID) represents a group of rare, sometimes fatal, congenital disorders characterized by little or no immune response. The defining feature of SCID, commonly known as "bubble boy" disease, is a defect in the specialized white blood cells (B- and T-lymphocytes) that defend us from infection by viruses, bacteria and fungi. Without a functional immune system, SCID patients are susceptible to recurrent infections such as pneumonia, meningitis and chicken pox, and can die before the first year of life. Though invasive, new treatments such as bone marrow and stem-cell transplantation save as many as 80% of SCID patients.  
ncbi.nlm.nih.gov
over 5 years ago
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Needle size for vaccination procedures in children and adolescents | Cochrane

Vaccines contain antigens that make our immune system produce antibodies that can protect against disease. Antigens are modified or partial forms of the virus, bacteria, or the toxin that cause the disease that the vaccine protects against. Because the antigen is altered from its original form it cannot cause disease, but it can produce an immune response.  
cochrane.org
over 5 years ago
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Cancer immunotherapy approved in UK - BBC News

A pioneering cancer drug that harnesses the power of the immune system is approved for use in the UK.  
bbc.co.uk
about 5 years ago
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Transfusions of white blood cells called granulocytes for preventing infections in people who lack functioning granulocytes | Cochrane

Review question We evaluated the evidence about whether granulocyte transfusions given to prevent infection are safe and decrease the risk of infection. Our target population was people with neutropenia (a very low count of a type of white blood cell (neutrophil), or white blood cells that did not function properly (neutrophil dysfunction).  
cochrane.org
about 5 years ago
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Fish oil (n-3 or omega-3) for pregnant mothers or breastfeeding mothers to prevent allergies in their young children | Cochrane

Fish and fish oil are the major sources of omega-3 long chain fatty acids. Dietary marine omega-3 fatty acid supplements during pregnancy may change the immune system of the newborn before allergic responses are established, particularly for those with a genetic predisposition to the production of the immunoglobulin E (IgE) antibody. Individuals with IgE-mediated allergies have both the signs and symptoms of the allergic disease and a positive skin prick test (SPT) to the allergen.  
cochrane.org
about 5 years ago
Www.bmj
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Skin disease in pregnancy

Pregnancy causes changes in the immune system that result in an increase in autoimmune disease and reduction in cell mediated immunity  
feeds.bmj.com
about 5 years ago
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Immunosuppressive agents for treating IgA nephropathy | Cochrane

IgA nephropathy is a common kidney disease that often leads to decreased kidney function and may result ultimately in kidney failure for one-third of affected people. The cause of IgA nephropathy is not known, although most people with the disease have abnormalities in their immune system. We identified 32 studies enrolling 1781 patients that met our inclusion criteria. This review found that if people with IgA nephropathy receive immunosuppressive drugs, particularly steroids, they may be less likely to develop kidney failure needing dialysis or transplantation. Few studies were available and the harms of therapy are currently not well understood. Larger placebo-controlled studies are now needed to be certain about the benefits and hazards of steroids on outcomes in IgA nephropathy and to identify which specific patients might benefit most from the treatment.  
cochrane.org
about 5 years ago
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Device Trains Immune Cells to Attack Cancer, Chronic Infections | Medgadget

Our immune systems have the capacity to fight many of what today are considered chronic conditions. Yet, unless there's an appropriate teaching exercise to  
medgadget.com
about 5 years ago
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Cryotherapy Procedure To Promotes Health and Wellness

The whole CRYO process re-energizes the body and promotes health and wellness. The CRYO procedure involves exposing the body or localized area to temperatures of -140C to unlock the body's self healing properties in addition to boosting your immune system and tripling your metabolism after each session where your body can burn up to 800 calories to assist in weight-loss!!! & tightens the face while increasing collagen production!!  
Max Anderson
about 5 years ago
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Dendritic cell - Wikipedia, the free encyclopedia

Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system. Their main function is to process antigen material and present it on the cell surface to the T cells of the immune system. They act as messengers between the innate and the adaptive immune systems.  
en.wikipedia.org
about 5 years ago
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Immune System Drives Pregnancy Complications after Fetal Surgery in Mice

UCSF researchers have shown that, in mice at least, pregnancy complications after fetal surgery are triggered by activation of the mother’s T cells.  
ucsf.edu
about 5 years ago
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New Matrix-based Neural Electrodes Offer Greater Biocompatibility for Brain Implants |

Brain implants that stay in the parenchyma for long periods of time can be attacked by the body's immune system or form an encapsulation layer referred to  
medgadget.com
about 5 years ago
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Polio: Vaccinated British man shed virus for 30 years - BBC News

A man with an immune system disorder has spread polio for nearly 30 years, despite having been vaccinated, British scientists have found.  
bbc.co.uk
about 5 years ago