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Innate immunity and normal flora (Medical Microbiology and Infection)

The innate immune system, which consists of the normal flora, physical barriers such as the skin, antibacterial proteins and phagocytic cells, is an important defence mechanism against infection. Many responses to ‘harm’ are detected by pattern recognition molecules such as […]  
what-when-how.com
over 5 years ago
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Mark Zuckerberg's book club fights US fear of vaccination

Facebook founder picks On Immunity by Eula Biss as American public health officials tackle major measles outbreak  
the Guardian
about 5 years ago
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Do all pathogens have associated molecules that can be detected by PRR in innate immunity?

I'm doing an essay on innate immunity and I need to know what it's pitfalls are  
Tamara Mulenga
over 7 years ago
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23

Encyclopedia of Stress: A-D

Stress is generally defined as a strain upon a bodily organ or mental power. Depending on its duration and intensity, stress can have short- or long-lasting effects: it has been linked to heart disease, immune deficiency, memory loss, behavioral disorders, and much more. These effects on the individual also have a major impact on health care costs and services, employee productivity, and even violent crime.The Encyclopedia of Stress is the first comprehensive reference source on stressors, the biological mechanisms involved in the stress response, the effects of activating the stress response mechanisms, and the disorders that may arise as a consequence of acute or chronic stress. While other books focus on specific aspects of stress, this three-volume set covers the entire spectrum of topics, with nearly 400 articles in all. In addition to the subjects traditionally associated with the hypothalamic-pituitary-adrenal axis (whereby the brain sends a message to the body to react), the Encyclopedia includes a wide range of related topics such as neuroimmune interactions, cytokines, enzymatic disorders, effects on the cardiovascular system, immunity and inflammation, and physical illnesses. It also goes beyond the biological aspects of stress to cover topics such as stress and behavior, psychiatric and psychosomatic disorders, workplace stress, post-traumatic stress, stress-reduction techniques, and current therapies. The Encyclopedia of Stress makes information easy to find and understand for a broad audience of researchers, clinicians, professionals, and students.Key Features* Presenting the first-ever encyclopedia on stress* Brings together the latest information on stressors, stress responses, and the disorders that can result* Covers stress from molecules to man to societies* Contains nearly 400 articles, covering a wide range of stress-related topics* Arranges topics in easily found alphabetical order* Supplements each article with a glossary and further reading list* Provides the most comprehensive coverage of stress available* Includes extensive cross-referencing between articles and a complete subject index* Covers hot topics, ranging from stress in the workplace and post-traumatic stress disorder to stress-related diseases* Edited by one of the world's leading authorities on stress* Written by more than 560 experts from 20 different countries* Appeals to a wide audience seeking information on topics within and outside their areas of expertise  
books.google.co.uk
about 5 years ago
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2

Skin based immunity secrets revealed

A team of international scientists has discovered a new mechanism by which immune cells in the skin function as the body's 'border control', revealing how these cells sense whether lipid or...  
medicalnewstoday.com
about 5 years ago
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Immunity to many types of flu viruses boosted by seasonal flu vaccines

Seasonal flu vaccines may protect individuals not only against the strains of flu they contain but also against many additional types, according to a study published this week in...  
medicalnewstoday.com
about 5 years ago
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Imaging immunity

Noninvasive imaging of immune system detects tumors, could monitor therapeutic responseA novel approach that allows real-time imaging of the immune system's response to...  
medicalnewstoday.com
about 5 years ago
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5

Scientists discover protein that boosts immunity to viruses and cancer

Scientists have discovered a protein that plays a central role in promoting immunity to viruses and cancer, opening the door to new therapies.  
medicalnewstoday.com
about 5 years ago
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3

New vaccine for Ebola found to provide long-lasting immunity in animals

Researchers have developed a new vaccine for Ebola virus they hope can be disseminated to provide vaccine coverage to inaccessible ape populations.  
medicalnewstoday.com
about 5 years ago
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12

Scientists discover robust evidence that chronic fatigue syndrome is a biological illness

Immune signatures in blood point to distinct disease stages, open door to better diagnosis and treatmentResearchers at the Center for Infection and Immunity at Columbia...  
medicalnewstoday.com
about 5 years ago
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6

Giving physicians immunity from malpractice claims does not reduce 'defensive medicine'

Changing laws to make it more difficult to sue physicians for medical malpractice may not reduce the amount of 'defensive medicine' practiced by physicians, according to a new RAND Corporation...  
medicalnewstoday.com
about 5 years ago
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5

Commensal microbiota influence systemic autoimmune responses

Antinuclear antibodies are a hallmark feature of generalized autoimmune diseases, including systemic lupus erythematosus and systemic sclerosis.  
medicalnewstoday.com
about 5 years ago
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2

'Substandard vaccination' blamed for measles outbreak

In a research letter, experts state that suboptimal vaccination levels have impaired community immunity to the disease and put the greater population at risk.  
medicalnewstoday.com
about 5 years ago
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2

Universal flu vaccine closer after natural immunity study

The solution to a universal flu vaccine may lie in stimulating the immune system's CD8 T cells, which attack the unchanging core of the virus and are high in the naturally immune.  
medicalnewstoday.com
about 5 years ago
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9

Cancer vaccines

Cancer vaccines are designed to promote tumor specific immune responses, particularly cytotoxic CD8 positive T cells that are specific to tumor antigens. The earliest vaccines, which were developed in 1994-95, tested non-mutated, shared tumor associated antigens that had been shown to be immunogenic and capable of inducing clinical responses in a minority of people with late stage cancer. Technological developments in the past few years have enabled the investigation of vaccines that target mutated antigens that are patient specific. Several platforms for cancer vaccination are being tested, including peptides, proteins, antigen presenting cells, tumor cells, and viral vectors. Standard of care treatments, such as surgery and ablation, chemotherapy, and radiotherapy, can also induce antitumor immunity, thereby having cancer vaccine effects. The monitoring of patients’ immune responses at baseline and after standard of care treatment is shedding light on immune biomarkers. Combination therapies are being tested in clinical trials and are likely to be the best approach to improving patient outcomes.  
feeds.bmj.com
about 5 years ago
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13

Cancer vaccines

Cancer vaccines are designed to promote tumor specific immune responses, particularly cytotoxic CD8 positive T cells that are specific to tumor antigens. The earliest vaccines, which were developed in 1994-95, tested non-mutated, shared tumor associated antigens that had been shown to be immunogenic and capable of inducing clinical responses in a minority of people with late stage cancer. Technological developments in the past few years have enabled the investigation of vaccines that target mutated antigens that are patient specific. Several platforms for cancer vaccination are being tested, including peptides, proteins, antigen presenting cells, tumor cells, and viral vectors. Standard of care treatments, such as surgery and ablation, chemotherapy, and radiotherapy, can also induce antitumor immunity, thereby having cancer vaccine effects. The monitoring of patients’ immune responses at baseline and after standard of care treatment is shedding light on immune biomarkers. Combination therapies are being tested in clinical trials and are likely to be the best approach to improving patient outcomes.  
feeds.bmj.com
about 5 years ago
C6b88f8f0764975b3ab68f0f2166e3a30ff94123964358951968523
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Innate immunity and Infection

A simplified schematic of innate immunity using Lobar pneumonia as an example  
Ken Laing
about 5 years ago
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Measures for preventing cold sores | Cochrane

A cold sore is an irritating recurrent viral infection with no proven cure. It gives rise to painful vesicles on the lips that form unsightly crusts, causing an unpleasant look and mental distress. We aimed to examine the effects of available measures for preventing recurrence of cold sores in people with normal immunity.  
cochrane.org
almost 5 years ago
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Generation and immunity testing of a recombinant adenovirus expressing NcSRS2-NcGRA7 fusion protein of bovine Neospora caninum

Korean J Parasitol. 2013 Apr;51(2):247-53. doi: 10.3347/kjp.2013.51.2.247. Epub 2013 Apr 25. Research Support, Non-U.S. Gov't  
ncbi.nlm.nih.gov
almost 5 years ago
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Wild forest lab studies immunity - BBC News

Patches of Kielder forest are being turned into a wild laboratories, to work out the environmental triggers for common diseases.  
bbc.co.uk
almost 5 years ago