Immunology

Young children with allergic rhinitis and allergic persistent wheezing may have increased risk for internalizing behaviors later on.  

Is it safe to use the intranasal attenuated influenza vaccine, which contains egg protein, in children and youth with egg allergy?  

Researchers suggest considering zoster vaccine for those aged 50 years and older with asthma. Their findings build on their previous work showing a link between childhood asthma and shingles.  

Clinicians from Massachusetts have developed an effective strategy to re-introduce taxane therapy after an initial hypersensitivity reaction.  

This activity is intended for dermatologists, pediatricians, and primary care/family practitioners who manage patients with atopic dermatitis.  

How does poorly controlled childhood asthma affect the stress and quality of life of the caregiver?  

A clear illustration of immunodeficiency disorders.  

Prothrombotic markers increase with asthma severity, potentially explaining increased risk for venous thromboembolism, according to a study from the Netherlands.  

Data from the ADEPT study provides insight into the clinical characteristics and biomarkers related to asthma.  

Rates of asthma prevalence in the United States are plateauing and possibly declining overall, but not for the poor.  

Switching from the older Zapletal reference values to the newer Global Lung Function Initiative (GLI) values can result in improved asthma treatment, researchers report.  

Low positive predictive value of serum immunoglobulin levels for the development of food allergies was seen in a longitudinal assessment of children with atopic dermatitis.  

An independent nonprofit organization that evaluates clinical and cost effectiveness of new medicines found the price of GlaxoSmithKline's new drug for severe asthma should be as much as 76% lower to justify its value, according to the group's latest draft report.  

: Experts in allergy immunotherapy discuss new findings presented at the ACAAI Annual Scientific Meeting.  

Is there a relationship between atopic dermatitis in childhood and the occurrence of hand eczema in adolescence?  

 

This review summarizes up-to-date insights and provides current management guidelines for Stevens-Johnson syndrome and toxic epidermal necrolysis, two life-threatening mucocutaneous drug reactions.  

The advisory committee ruled that evidence wasn't strong enough for recommending the drug for children aged 12 to 17 years, citing small numbers in studies; concerns include risk for anaphylaxis and muscle toxicity.  

What is the potential for anaphylaxis in oral allergy syndrome?  

Influenza vaccine is egg derived and has been contraindicated in people with egg allergy. It contains low residual levels of the egg protein ovalbumin and its use in people with egg allergy theoretically risks an allergic reaction.1 However, no study has shown that residual ovalbumin content can cause adverse events (including anaphylaxis related morbidity or mortality) in egg allergic recipients, or that vaccination is riskier for these recipients than for the general population.2 Many allergy specialists have circumvented the contraindication by using vaccine skin testing, vaccine desensitisation, and vaccines containing low concentrations of ovalbumin (<1.2 µg/mL). But governmental agencies and vaccine manufacturers have continued to issue this contraindication annually.2 3