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6

Plant chemicals may prevent liver damage caused by fat accumulated during menopause

Women going through menopause often struggle with weight gain that results when their estrogen levels drop, and many turn to weight-loss supplements to help them shed those extra pounds.  
medicalnewstoday.com
over 5 years ago
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5

D-LIVER: EU project designs home care system for liver patients

A European ICT for Health project aims to improve the quality of life of patients with chronic liver disease, by developing a remote support system to monitor their condition at home.  
medicalnewstoday.com
over 5 years ago
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6

Statin use associated with reduced risk of liver cancer among those in the UK

In a nested-case control study of individuals living in the UK, a part of the world with a relatively low incidence of liver cancer, statin use is associated with a decreased risk of liver...  
medicalnewstoday.com
over 5 years ago
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3

'Open' stem cell chromosomes reveal new possibilities for diabetes

Researchers map chromosomal changes that must take place before stem cells can be used to produce pancreatic and liver...  
medicalnewstoday.com
over 5 years ago
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Rebooting cell programming can reverse liver failure, says Children's Hospital/Pitt study

It might be possible to heal cirrhotic liver disease by rebooting the genes that control liver cell function, according to researchers at Children's Hospital of Pittsburgh of UPMC and the...  
medicalnewstoday.com
over 5 years ago
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Hepatitis C Will Share Spotlight This Year at Liver Congress

Specialists will learn how to prioritize hepatitis C drugs, and hear more about fatty liver disease, hepatocellular cancer, and the noninvasive assessment of liver disease.  
medscape.com
over 5 years ago
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20

Acute Liver Failure: Treatment (Part 2 of 2)

Management of acute liver failure is largely supportive critical care for the multiorgan failure that frequently results. Severe acute liver failure results in rapidly progressive hepatic encephalopathy and lethal cerebral edema; this complication requires special vigilance and expert management. Hypoglycemia, hyponatremia, and metabolic disturbances from renal failure may also require continual attention. Whenever possible, transfer to a liver transplant center should be considered for any patient with severe acute liver failure. If this is not possible, local or remote consultation of a liver transplant physician (hepatologist and/or transplant surgeon) should be sought, as well as a neurologist.  
pulmccm.org
over 5 years ago
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12

Acute Liver Failure: Causes & Initial Management (Part 1 of 2)

Acute liver failure, also called fulminant liver failure, has been defined as "a severe liver injury, potentially reversible in nature and with onset of hepatic encephalopathy within 8 weeks of the first symptoms in the absence of pre-existing liver disease." Acute liver failure is relatively uncommon (about 1 in 100,000 per year in developed countries), most often affects previously healthy young adults, and was historically usually fatal. Today, advances in emergency liver transplantation for acute liver failure have improved survival, making early recognition and proper management of acute liver failure more important than ever.  
pulmccm.org
over 5 years ago
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Episode 6 – Hepatic Emergencies

Episode 6 – Liver Emergencies (iTunes or Listen Here)  This episode is a response to Dr. Nick Genes tweet: Really, with all the #FOAMed goodness out there in EM, no love for the liver? I suppose not as sexy as other topics, right @TheSGEM ? — borborygmi (@nickgenes) June 11, 2014  Here's the slideset he posted, filled with excellent…  
foamcast.org
over 5 years ago
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1

First steps in basic process could be harnessed to make therapeutic cells

Understanding the molecular signals that guide early cells in the embryo to develop into different types of organs provides insight into how tissues regenerate and repair themselves. By knowing the principles that underlie the intricate steps in this transformation, researchers will be able to make new cells at will for transplantation and tissue repair in such situations as liver or heart disease.  
sciencedaily.com
over 5 years ago
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6

All in a Day's Work

This article was previously published In the Loop It began in the early afternoon of March 3 when the news was received that a liver w…  
newsnetwork.mayoclinic.org
over 5 years ago
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Critical Care

Although the prognostic value of persistent hyperlactatemia in septic shock is unequivocal, its physiological determinants are controversial. Particularly, the role of impaired hepatic clearance has been underestimated and is only considered relevant in patients with liver ischemia or cirrhosis. Our objectives were to establish whether endotoxemia impairs whole body net lactate clearance, and to explore a potential role for total liver hypoperfusion during the early phase of septic shock.  
ccforum.com
over 5 years ago
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1

Mini 3D printed organs mimic beating heart and liver

Watch a collection of tiny beating hearts and a heart fused to a liver, made using techniques that could one day help build a human on a chip  
feeds.newscientist.com
over 5 years ago
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53

Liver Pathology

This unique book provides detailed insight into a wealth of expert experience in liver pathology, with an in-depth review of the expertÌs analysis and diagnostic process supported by high-quality color photomicrographs and discussion of the diagnostic principles involved in evaluating these lesions. The diagnostic problems and cases selected show the wide range of specimens seen in liver pathology and address the difficult issues in diagnosis encountered in these lesions. Chapters and cases are authored by many of the leading experts and educators in liver pathology today. Liver Pathology will be essential reading for every pathologist who evaluates liver pathology specimens. In addition it will be a valuable resource for pathology residents and fellows. All Consultant Pathology Titles Provide: Actual consultation cases and expert analysis Expert analysis provides a detailed discussion of the reasoning behind the diagnosis of each case Comprehensive coverage of challenging diagnoses The cases are richly illustrated with high-quality photomicrographs  
books.google.co.uk
over 5 years ago
Www.bmj
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Transplant surgeon who fast tracked patients is found not guilty of attempted manslaughter

An organ transplantation surgeon who allegedly manipulated data to make some patients seem sicker than they were so that they could be moved up the waiting list for donated livers has been found not guilty of attempted manslaughter and premeditated bodily harm with fatal consequences by a German court.  
feeds.bmj.com
over 5 years ago
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Transplant surgeon who fast tracked patients is found not guilty of attempted manslaughter

An organ transplantation surgeon who allegedly manipulated data to make some patients seem sicker than they were so that they could be moved up the waiting list for donated livers has been found not guilty of attempted manslaughter and premeditated bodily harm with fatal consequences by a German court.  
feeds.bmj.com
over 5 years ago
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Tafenoquine for preventing relapse in people with vivax malaria | Cochrane

Vivax malaria is caused by the parasite Plasmodium vivax. The disease includes a stage of liver infection and this can cause relapse unless treated. The only drug available until recently was primaquine, but this requires a 14-day course of treatment. Alternatives have been tried, one of which is tafenoquine, which does not need such a long course of treatment. Both primaquine and tafenoquine can cause haemolysis in people with glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency, which is a common genetic defect. We conducted a Cochrane Review on the effect of the drug tafenoquine on clearing the dormant P. vivax parasites in infected patients to prevent a relapse.  
cochrane.org
over 5 years ago
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125

Gastrulation Lecture

Following the implantation of the blastocyst into the endometrium of uterus, the embryo begins another important embryological process called gastrulation. Gastrulation is the formation of the three distinct germ layers - the ectoderm, the mesoderm and the endoderm. The ectoderm is the outermost layer of the developing embryo and it consists of cells that eventually give rise to the integumentary system (the outer skin, nails and hair) as well as the nervous system (central and peripheral system). The mesoderm is the middle layer of the developing embryo and it consists of cells that eventually give rise to the musculoskeletal system (bone, cartilage, skeletal muscle, cardiac muscle, smooth muscle), cardiovascular system (the heart and blood vessels), excretory system (kidneys) and reproductive system (gonads). The endoderm is the innermost layer of the developing embryo and it gives rise to the epithelial layer of the digestive tract, lungs, pancreas, bladder, liver as well as the thyroid gland, parathyroid gland and thymus.  
aklectures.com
over 5 years ago
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108

Acetaminophen Pathway (therapeutic doses), Pharmacokinetics

Acetaminophen (N-acetyl-p-aminophenol, APAP, or paracetamol, PARA) is widely used for its analgesic and antipyretic properties in many over-the-counter formulations in both adults and children [Articles:21054454, 23719833]. APAP can be synthesized in the body through O-dealkylation of the prodrug phenacetin, a pain-killer that was withdrawn from the market due to nephrotoxicity and carcinogenesis [Article:7002186]. At the therapeutic adult dose of 1-2 g/day, oral APAP is indicated for fever and mild to moderate acute pain conditions [Article:23719833]. Administration of acetaminophen via intravenous route has become increasingly widespread and has been used as a safe and effective antipyretic and analgesic agent [Article:25521845]. Maximum recommended therapeutic dose of APAP is 4 g/day in adults and 50-75 mg/kg/day in children. Consumption of a single dose greater than 7 g in an adult and 150 mg/kg in a child is considered potentially toxic to the liver and kidneys due to the highly active metabolite N-acetyl-p-benzoquinone imine (NAPQI)[Article:22998987].  
pharmgkb.org
over 5 years ago