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Atypical Spitz Nevi

Atypical Spitz nevi can present a diagnostic challenge. How are they differentiated from malignant melanoma, and what management strategies are recommended?  
medscape.com
about 4 years ago
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NEJM Study: Mutations ID'd That Lead to Melanoma

An analysis of gene mutations showed that the path to melanoma varied according to precursor lesion, that 'high-risk' lesions had genetic markers, and that UV light played a role throughout.  
medscape.com
about 4 years ago
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FDA Approves Cotellic as Part of Melanoma Combination

The MEK inhibitor cobimetinib (Cotellic, Roche) works with already-approved vemurafenib for the treatment of advanced melanoma that is BRAF mutation-positive.  
medscape.com
about 4 years ago
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Sentinel lymph node biopsy in melanoma

There are two diametrically opposed positions on the role of sentinel lymph node biopsy in the management of patients with melanoma. Either sentinel node biopsy affords patients with the best prognostic information and biopsy followed by complete lymph node dissection provides a survival advantage for patients with intermediate thickness melanomas, or the procedures are expensive and invasive, add little or no prognostic information, and have no survival advantage. The lack of consensus is reflected in the ambiguity of guidelines internationally.1 2 3 4 5  
feeds.bmj.com
about 4 years ago
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Sentinel lymph node biopsy in melanoma

There are two diametrically opposed positions on the role of sentinel lymph node biopsy in the management of patients with melanoma. Either sentinel node biopsy affords patients with the best prognostic information and biopsy followed by complete lymph node dissection provides a survival advantage for patients with intermediate thickness melanomas, or the procedures are expensive and invasive, add little or no prognostic information, and have no survival advantage. The lack of consensus is reflected in the ambiguity of guidelines internationally.1 2 3 4 5  
feeds.bmj.com
about 4 years ago
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FDA Approves Ipilimumab (Yervoy) for Use in Stage III Melanoma

Ipilimumab is now approved for use as an adjuvant therapy for patients with resectable melanoma that has spread to the lymph nodes, the agency announced today.  
medscape.com
about 4 years ago
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Improving outcomes for people with skin tumours including melanoma | Guidance and guidelines | NICE

The NICE guidance on skin cancer services outlines how healthcare services for people with skin tumours should be organised. The key recommendations include:  
nice.org.uk
about 4 years ago
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Melanoma: assessment and management | Guidance and guidelines | NICE

Evidence-based recommendations on assessing and managing melanoma (a type of skin cancer).  
nice.org.uk
about 4 years ago
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FDA Approves Imlygic, First Oncolytic Viral Therapy in the US

The FDA has given the green light to talimogene laherparepvec for the treatment of advanced melanoma, making it the first oncolytic viral therapy to be approved for sale in the United States.  
medscape.com
about 4 years ago
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Systemic Options for Treating Brain Metastases

The therapeutic challenge of brain metastases in lung cancer, breast cancer, and melanoma is being met by a growing number of systemic therapies, as highlighted in an integrated session of ECC 2015.  
medscape.com
about 4 years ago
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Antioxidants May Promote Metastasis in Melanoma

An experimental study suggests that oxidative stress limits distant metastasis in melanoma, but administering antioxidants helps the cancer cells to survive and spread.  
medscape.com
about 4 years ago
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EU Likes Melanoma Therapy Injected Directly Into Lesions

The product, talimogene laherparepvec, has also recently been recommended for approval in the United States.  
medscape.com
about 4 years ago
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Simple Melanoma Risk Test: Count the Moles on an Arm

The total number of nevi on the body, which is a predictor of melanoma risk, can be estimated simply by counting the number of moles on an arm, say UK and Italian scientists.  
medscape.com
about 4 years ago
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Arm mole count 'predicts skin cancer risk' - BBC News

Having more than 11 moles on one arm could be an indication of a higher risk of skin cancer or melanoma, research suggests.  
bbc.co.uk
about 4 years ago
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Apple ResearchKit Data to Be Used in Three Clinical Studies

Academic medical centers will use iPhone apps to study autism, epilepsy, and melanoma; might later build marketable apps and apply for FDA clearance.  
medscape.com
about 4 years ago
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Nivolumab: Immunotherapy in Malignant Melanoma

Melanoma rates have been steadily increasing since the 1970s, but cytotoxic chemotherapy generally prolongs survival.  
medscape.com
about 4 years ago
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Cotellic Combination Therapy Effective in Melanoma

Final survival data from the Phase III coBRIM clinical trial showed the drug cobimetinib (Cotellic) used in combination with vemurafenib (Zelboraf) helped patients with previously untreated BRAF V600 mutation-positive advanced melanoma live significantly longer compared to Zelboraf alone.  
medscape.com
about 4 years ago
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Immunotherapy Combo for Melanoma Approved by FDA

This is the first FDA approval of an immunotherapy combination for a cancer.  
medscape.com
about 4 years ago
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EU Panel Likes Multiple Myeloma, Leukemia, Melanoma Drugs

A recommendation from the Committee for Medicinal Products for Human Use usually results in eventual marketing approval.  
medscape.com
about 4 years ago
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A Patient With BRAF Wild-Type Metastatic Melanoma CME

This activity is intended for oncologists, dermatologists, and other healthcare professionals who treat patients with melanoma.  
medscape.org
about 4 years ago