New to Meducation?
Sign up
Already signed up? Log In
view moderators

Meta-Analysis

Category

8
1
30

Meta-analysis of Glucose Control

Tight glucose control has been widely introduced into critical care This meta-analysis, recently published in JAMA, critically evaluate the effects of these trials in reduction of sepsis as well a mortality. The results might surprise you.  
Jeffrey S. Guy, MD, FACS
almost 9 years ago
7
1
38

Hemoglobin Based Blood Substitutes: Increased Morbidity and Mortality

In this week's <em>Journal of the American Medical Association</em> a meta-analysis was published that concluded that use of hemoglobin based blood substitutes result in an increased morbidity and mortality.&nbsp; Included in the same journal is an editorial critical of the method the research has been regulated by the US FDA.&nbsp;&nbsp;  
Jeffrey S. Guy, MD, FACS
almost 9 years ago
Podcast 5
8
43

Capnography for Diagnosis of Pulmonary Embolism; a Useful Tool or a Load of Hot Air?

What benefit does a recent meta-analysis show for the use of ETCO2 in the diagnosis of PE? A review of the results and a refresher on the use of likelihood ratios in clinical practice.  
heftemcast.co.uk
over 5 years ago
Www.bmj
1
29

Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis

Objective To provide an accurate assessment of complications of pregnancy in women with chronic hypertension, including comparison with population pregnancy data (US) to inform pre-pregnancy and antenatal management strategies.  
bmj.com
over 5 years ago
Www.bmj
1
27

Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies

Objective To investigate the risk of pancreatitis associated with the use of incretin-based treatments in patients with type 2 diabetes mellitus.  
bmj.com
over 5 years ago
Preview
1
17

Statins may have fewer side effects than is claimed, meta-analysis finds

Only a few types of side effect reported from use of statins are genuinely due to the drug itself, as almost all side effects were reported just as often with a placebo, a systematic review of randomised controlled trials has concluded.1  
bmj.com
over 5 years ago
Www.bmj
1
27

Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies

Objective To investigate the risk of pancreatitis associated with the use of incretin-based treatments in patients with type 2 diabetes mellitus.  
www.bmj.com
over 5 years ago
Www.bmj
1
16

Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies

Objectives To review, summarise, and compare the evidence for effectiveness of screening sigmoidoscopy and screening colonoscopy in the prevention of colorectal cancer occurrence and deaths.  
bmj.com
over 5 years ago
Www.bmj
1
14

Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies

Objectives To review, summarise, and compare the evidence for effectiveness of screening sigmoidoscopy and screening colonoscopy in the prevention of colorectal cancer occurrence and deaths.  
bmj.com
over 5 years ago
Www.bmj
1
13

Smoking bans are linked to reduction in preterm births and childhood asthma, says study

Rates of preterm births and paediatric hospital admissions for asthma fell by 10% within a year of smoke-free legislation taking effect, says a systematic review and meta-analysis on the issue.1  
bmj.com
over 5 years ago
Www.bmj
1
18

Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies

Objectives To review, summarise, and compare the evidence for effectiveness of screening sigmoidoscopy and screening colonoscopy in the prevention of colorectal cancer occurrence and deaths.  
bmj.com
over 5 years ago
Www.bmj
1
28

Discrepancies in autologous bone marrow stem cell trials and enhancement of ejection fraction (DAMASCENE): weighted regression and meta-analysis

Objective To investigate whether discrepancies in trials of use of bone marrow stem cells in patients with heart disease account for the variation in reported effect size in improvement of left ventricular function.  
www.bmj.com
over 5 years ago
Preview
2
35

Comparative effectiveness of long term drug treatment strategies to prevent asthma exacerbations: network meta-analysis

Objective To determine the comparative effectiveness and safety of current maintenance strategies in preventing exacerbations of asthma.  
bmj.com
over 5 years ago
Www.bmj
1
20

Maintenance treatment for adults with chronic asthma

Which treatment for asthma is most likely to reduce the risk of exacerbations in adults? In a linked paper, Loymans and colleagues (doi:10.1136/bmj.g3009) seek to address this question using network meta-analysis.1 The authors identified and compared 16 different treatment approaches, using evidence from randomised trials of at least 24 weeks’ duration. The primary outcome was severe exacerbations (leading to admission to hospital, a visit to the emergency department, or a course of oral steroids).  
bmj.com
over 5 years ago
Preview
1
19

Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trials

Objectives To determine whether searching for Helicobacter pylori and treating with eradication therapy leads to a reduction in incidence of gastric cancer among healthy asymptomatic infected individuals.  
bmj.com
over 5 years ago
Www.bmj
1
18

Cutaneous melanoma attributable to sunbed use: systematic review and meta-analysis

Data sources PubMed, ISI Web of Science (Science Citation Index Expanded), Embase, Pascal, Cochrane Library, LILACS, and MedCarib, along with published surveys reporting prevalence of sunbed use at national level in Europe.  
bmj.com
over 4 years ago
Preview
1
16

Blood pressure targets for type 2 diabetes should be lower, say researchers

Recent changes to guidelines on lowering blood pressure in patients with type 2 diabetes should be reconsidered to reinstate the lower target level, researchers have said in JAMA after carrying out a meta-analysis of randomised controlled trials.1  
bmj.com
over 4 years ago
Static.www.bmj
1
18

The diagnostic accuracy of the natriuretic peptides in heart failure: systematic review and diagnostic meta-analysis in the acute care setting

Objectives To determine and compare the diagnostic accuracy of serum natriuretic peptide levels (B type natriuretic peptide, N terminal probrain natriuretic peptide (NTproBNP), and mid-regional proatrial natriuretic peptide (MRproANP)) in people presenting with acute heart failure to acute care settings using thresholds recommended in the 2012 European Society of Cardiology guidelines for heart failure.  
bmj.com
over 4 years ago
Www.bmj
1
17

Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials

Objective To evaluate the relative risk of pulmonary disease among patients with psoriasis, psoriatic arthritis, and inflammatory bowel disease treated with methotrexate.  
bmj.com
over 4 years ago
Www.bmj
2
47

Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials

Objective To evaluate the relative risk of pulmonary disease among patients with psoriasis, psoriatic arthritis, and inflammatory bowel disease treated with methotrexate.  
bmj.com
over 4 years ago