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Meta-Analysis

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TAVI, SAVR Outcomes Not Significantly Different in Short Term

Early and midterm outcomes of transcatheter aortic valve implantation (TAVI) are not significantly different from those of surgical aortic valve replacement (SAVR) in patients treated for severe aortic stenosis, according to a new meta-analysis.  
medscape.com
about 4 years ago
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Most antidepressants are ineffective in children and teenagers, study shows

Most currently available antidepressants “do not seem to offer a clear advantage” in children and teenagers with major depression, a comprehensive meta-analysis has shown.1  
feeds.bmj.com
about 4 years ago
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Second-generation Antipsychotics: Not All Equal

A systematic review and meta-analysis of various second-generation antipsychotic agents in the treatment of first-episode psychosis finds that not all are created equal.  
medscape.com
about 4 years ago
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Under-representation of frail older people in meta-analysis of dipeptidyl peptidase-4 inhibitors and hypoglycaemia

Salvo and colleagues’ meta-analysis is limited by the under-representation of frail older people.1 The study by Barnett and colleagues was the only …  
feeds.bmj.com
about 4 years ago
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Inclusion of the EXAMINE study in a meta-analysis of the addition of dipeptidyl peptidase-4 inhibitors to sulphonylureas and risk of hypoglycaemia

The main eligibility criterion in Salvo and colleagues’ meta-analysis on the increased risk of hypoglycaemia was that trials studied the effect of adding one dipeptidyl peptidase-4 (DPP-4) inhibitor or placebo to sulphonylureas.1  
feeds.bmj.com
about 4 years ago
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Authors’ reply to Tufan and colleagues and Boucaud-Maitre

In response to Tufan and colleagues, it is true that older frail patients are under-represented in our meta-analysis, but such patients are under-represented in clinical trials in general, not just those investigating type 2 diabetes.1 2 Even when there is no formal age limit, the common exclusion of patients with organ dysfunction and comorbidities means that most older people are excluded.3 We can but hope that further trials will provide more information on benefits and risks of drugs in older people and will update …  
feeds.bmj.com
about 4 years ago
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Opioid Analgesics Subpar for Chronic Back Pain

Opioid analgesics are commonly prescribed but fail to have a significant effect, a meta-analysis has found. A pain medication specialist says even with low effect, it should remain a tool in the arsenal.  
medscape.com
about 4 years ago
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Tai Chi Resembles Drugs, Aerobics in Blood Pressure Lowering

Results from a new meta-analysis suggest that tai chi can lower blood pressure in older people as effectively as drugs or other exercise.  
medscape.com
about 4 years ago
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Could a Prior Pregnancy Termination Increase Preterm Delivery Risk?

Dr Peter Kovacs reviews a meta-analysis that evaluated the impact of prior pregnancy termination on subsequent risk for preterm delivery.  
medscape.com
about 4 years ago
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Vitamin D Deficiency Linked to Diabetic Retinopathy

A systematic review and meta-analysis find association, but the mechanism isn't clear, and no randomized clinical trials of supplementation have been conducted as yet.  
medscape.com
about 4 years ago
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NOACs Best Warfarin in Mortality Meta-analysis

Dr Goldhaber comments on a study that shows a lower risk for early mortality in patients who took NOACs compared with those who took warfarin.  
medscape.com
about 4 years ago
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Corticosteroids Reduce Exacerbations in Preschoolers With Recurrent Wheeze

Inhaled corticosteroids reduce exacerbations of recurrent wheezing in preschoolers, according to a meta-analysis.  
medscape.com
about 4 years ago
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Rind et al. controversy - Wikipedia, the free encyclopedia

The Rind et al. controversy was a debate in the scientific literature, public media, and government legislatures in the United States regarding a 1998 peer reviewed meta-analysis of the self-reported harm caused by child sexual abuse (CSA).[1] The debate resulted in the unprecedented condemnation of the paper by both Houses of the United States Congress. The social science research community was concerned that the condemnation by government legislatures might have a chilling effect on the future publication of controversial research results.  
en.wikipedia.org
about 4 years ago
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Mindfulness Therapy May Prevent Depression Relapse

Mindfulness-based cognitive therapy substantially reduces the risk for relapse in patients with recurrent depression, a new meta-analysis confirms.  
medscape.com
about 4 years ago
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Probiotics Keep C difficile at Bay in Patients on Antibiotics

Probiotics can protect against Clostridium difficile infection in hospitalized patients receiving antibiotics. In a new meta-analysis, infection rates were cut by more than half.  
medscape.com
about 4 years ago
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Supraglottoplasty Effective for Children With Laryngomalacia

Supraglottoplasty relieves obstructive sleep apnea (OSA) in children with laryngomalacia, but residual disease is common, according to a new meta-analysis of four studies.  
medscape.com
about 4 years ago
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Personalized Medicine Delivers Better Outcomes: More Proof

A large meta-analysis found that a personalized strategy was an independent predictor of improved outcomes even in phase 1 trials.  
medscape.com
about 4 years ago
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FDG-PET Is Prognostic in Soft-Tissue Bone Sarcomas

Patients whose tumors had higher uptake of radiotracer had significantly worse prognoses than patients whose tumors had low uptake, results of a systematic review and meta-analysis show.  
medscape.com
about 4 years ago
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Psoriatic Arthritis, Cardiovascular Disease Link Confirmed

Patients with psoriatic arthritis have a 55% higher risk for incident cardiovascular events than do people in the general population, according to a new meta-analysis.  
medscape.com
about 4 years ago
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Hemophilia Products Do Not Raise Antibody Risk, Says EMA

The evidence does not indicate that two recombinant factor VIII products from Bayer increase the risk for inhibitors that render treatment ineffective, EU regulators said in a meta-analysis.  
medscape.com
about 4 years ago