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31

Lifestyle changes or metformin reduce type 2 diabetes risk in women with gestational diabetes, US study shows

Women with gestational diabetes have an increased risk of type 2 diabetes for years after giving birth, but intensive lifestyle changes or metformin therapy reduce this risk by more than a third, a US study has found.  
bmj.com
over 5 years ago
Www.bmj
1
16

Improving diabetes prevention with benefit based tailored treatment: risk based reanalysis of Diabetes Prevention Program

Objective To determine whether some participants in the Diabetes Prevention Program were more or less likely to benefit from metformin or a structured lifestyle modification program.  
bmj.com
over 5 years ago
Www.bmj
1
39

A patient with type 2 diabetes and a burning sensation in his feet

A 64 year old man with type 2 diabetes diagnosed nine years earlier attended the outpatient diabetes clinic because of suboptimal diabetes control. His glycated haemoglobin over the past five years had been 64-77 mmol/mol (8-9.2%; optimal value <53 mmol/mol (7%)). He was being treated for diabetes with gliclazide and metformin. He also received simvastatin and enalapril for dyslipidaemia and hypertension, respectively, and 75 mg acetylsalicylic acid daily for the prevention of primary cardiovascular disease.  
bmj.com
over 5 years ago
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0
15

Using metformin in the presence of renal disease

In January, the electronic Medicines Compendium (eMC) updated the Summary of Product Characteristics for Glucophage (metformin), approved by the UK Medicines and Healthcare Products Regulatory Agency (MHRA). The summary states that “Metformin may be used in patients with moderate renal impairment, stage 3a (creatinine clearance [CrCl] 45-59 mL/min or estimated glomerular filtration rate [eGFR] 45-59 mL/min/1.73 m2) only in the absence of other conditions that may increase the risk of lactic acidosis . . . If CrCl or eGFR fall <45 mL/min or <45 mL/min/1.73 m2 respectively, metformin must be discontinued immediately.”1 This is reiterated in the patient information leaflet.  
feeds.bmj.com
over 5 years ago
Www.bmj
0
15

Lifestyle changes or metformin reduce type 2 diabetes risk in women with gestational diabetes, US study shows

Women with gestational diabetes have an increased risk of type 2 diabetes for years after giving birth, but intensive lifestyle changes or metformin therapy reduce this risk by more than a third, a US study has found.  
feeds.bmj.com
over 5 years ago
Www.bmj
0
9

Improving diabetes prevention with benefit based tailored treatment: risk based reanalysis of Diabetes Prevention Program

Objective To determine whether some participants in the Diabetes Prevention Program were more or less likely to benefit from metformin or a structured lifestyle modification program.  
feeds.bmj.com
over 5 years ago
Www.bmj
0
6

Using metformin in the presence of renal disease

Register for a free trial to thebmj.com to receive unlimited access to all content on thebmj.com for 14 days. Sign up for a free trial  
feeds.bmj.com
over 5 years ago
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0
5

Using metformin in the presence of renal disease

In January, the electronic Medicines Compendium (eMC) updated the Summary of Product Characteristics for Glucophage (metformin), approved by the UK Medicines and Healthcare Products Regulatory Agency (MHRA). The summary states that “Metformin may be used in patients with moderate renal impairment, stage 3a (creatinine clearance [CrCl] 45-59 mL/min or estimated glomerular filtration rate [eGFR] 45-59 mL/min/1.73 m2) only in the absence of other conditions that may increase the risk of lactic acidosis . . . If CrCl or eGFR fall <45 mL/min or <45 mL/min/1.73 m2 respectively, metformin must be discontinued immediately.”1 This is reiterated in the patient information leaflet.  
feeds.bmj.com
over 5 years ago
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0
3

Onion extract may improve high blood sugar and cholesterol

The extract of onion bulb, Allium cepa, strongly lowered high blood glucose (sugar) and total cholesterol levels in diabetic rats when given with the antidiabetic drug metformin, according to a...  
medicalnewstoday.com
over 5 years ago
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0
3

Two compounds target the gut to lower blood sugar -- in obese or diabetic rats

Researchers at the Toronto General Hospital Research Institute have discovered metformin (the most widely prescribed type 2 diabetic medication) and resveratrol, a compound found in red wine...  
medicalnewstoday.com
over 5 years ago
Www.bmj
0
3

Scant evidence on the effectiveness of metformin in type 2 diabetes

Metformin is remarkably safe compared with alternative drugs for type 2 diabetes, although it does cause at least chemical vitamin B12 deficiency.1 2 The “problem” of reduced glomerular filtration can be seen as an advantage for drugs like metformin that are eliminated through the kidney. Reduced …  
feeds.bmj.com
over 5 years ago
Preview
0
15

Scant evidence on the effectiveness of metformin in type 2 diabetes

Metformin is remarkably safe compared with alternative drugs for type 2 diabetes, although it does cause at least chemical vitamin B12 deficiency.1 2 The “problem” of reduced glomerular filtration can be seen as an advantage for drugs like metformin that are eliminated through the kidney. Reduced …  
feeds.bmj.com
about 5 years ago
Www.bmj
0
9

A patient with type 2 diabetes and a burning sensation in his feet

A 64 year old man with type 2 diabetes diagnosed nine years earlier attended the outpatient diabetes clinic because of suboptimal diabetes control. His glycated haemoglobin over the past five years had been 64-77 mmol/mol (8-9.2%; optimal value <53 mmol/mol (7%)). He was being treated for diabetes with gliclazide and metformin. He also received simvastatin and enalapril for dyslipidaemia and hypertension, respectively, and 75 mg acetylsalicylic acid daily for the prevention of primary cardiovascular disease.  
feeds.bmj.com
about 5 years ago
Www.bmj
0
21

A woman with macrocytic anaemia and confusion

An 82 year old woman with a history of type 2 diabetes presented with unsteady gait and confusion of two months’ duration. Her diabetes was controlled by metformin (500 mg, three times a day) and she had no other comorbidities. She was a non-smoker and did not drink alcohol. Dietary history showed an adequate intake of meat, vegetables, and calories.  
feeds.bmj.com
about 5 years ago
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325

Hypoglycemic drugs for diabetes treatment - Ahmados

One A3 note summarize the hypoglycemic drugs ( mechanism of action , uses , side effects ) and how to approach a patient with diabetes.  
Ahmados Academy
about 5 years ago
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0

Metformin Link to Vitamin B12 Deficiency, Neuropathy in Diabetes

Researchers link 4 years of metformin use to a net worsening of peripheral neuropathy in type 2 diabetes, even after accounting for improvements from HbA1c lowering.  
medscape.com
almost 5 years ago
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1

How Effective Is Metformin Plus Clomiphene in Women With PCOS?

Dr Peter Kovacs summarizes a systemic review comparing metformin plus clomiphene vs gonadotropins and other treatments for improving fertility in women with clomiphene-resistant PCOS.  
medscape.com
almost 5 years ago
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0

Metformin May Increase Height in Children, Adolescents

Higher cumulative doses of metformin may promote small increases in height in children and adolescents compared with patients who do not receive the drug.  
medscape.com
almost 5 years ago
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0
1

The Pleiotropic Effects of Metformin

This commentary discusses the need for well-designed studies that examine the cardioprotective role of the glucose-lowering agent metformin.  
medscape.com
almost 5 years ago
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0

Metformin Intolerance Increased by Genes, Other Meds

In two studies, certain gene variants and medications that inhibit the action of a metformin transporter in the gut increased the likelihood of drug gastrointestinal side effects.  
medscape.com
almost 5 years ago