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Treat Neonatal Diabetes Early With Sulfonylureas

Children with neonatal diabetes due to potassium-channel mutations show neurodevelopmental benefits from treatment with sulfonylureas. The earlier they are treated, the better.  
medscape.com
almost 5 years ago
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Microbiome May Predict Colon Cancer Tumor Mutational Status

The characterization of the microbiome of a tumor can be used to predict the presence of a specific mutation, new research shows.  
medscape.com
almost 5 years ago
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Gene Mutation Signals Poor Prognosis for Pancreatic Tumors

Recently identified mutations in two key genes are prognostic of poor outcome in patients with pancreatic neuroendocrine tumors, researchers report.  
medscape.com
almost 5 years ago
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Cotellic Combination Therapy Effective in Melanoma

Final survival data from the Phase III coBRIM clinical trial showed the drug cobimetinib (Cotellic) used in combination with vemurafenib (Zelboraf) helped patients with previously untreated BRAF V600 mutation-positive advanced melanoma live significantly longer compared to Zelboraf alone.  
medscape.com
almost 5 years ago
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Mutations in Brain Metastases Raise Hope for Therapy

More than half of brain metastases from primary tumors have unique genetic mutations that may make them targets for effective therapy, say US researchers.  
medscape.com
almost 5 years ago
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CHMP Backs Combo Drug Orkambi for Cystic Fibrosis

Orkambi combines lumacaftor and ivacaftor and is indicated for patients with CF aged 12 years and older who are homozygous for the F508del mutation in the CFTR gene.  
medscape.com
almost 5 years ago
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Young Lung Cancer Patients: Prime for Targeted Therapies

Individuals younger than 40 years who develop lung cancer tend to have high rates of actionable mutations, making them candidates for new targeted therapies.  
medscape.com
about 5 years ago
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254

AZD9291 Produces Strong Responses in EGFR-Mutated NSCLC

The investigational third-generation tyrosine kinase inhibitor has shown promising results both as a first-line therapy and in pretreated patients who harbor EGFR mutations.  
medscape.com
about 5 years ago
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What is The Calmare Pain Therapy treatment? -

Chronic pain is at an epidemic level in the United States. Many types of chronic pain are very difficult to diagnosis and treat, as it can be a genetic code mutation (hereditary), the result of another underlying cause, or progressive or chronic Peripheral Neuropathy. A new neurotheraphy has been helping Peripheral Neuropathy sufferers across the globe alleviate advanced cases of pain by a non-invasive FDA cleared electrostimulation therapy: The Calmare Pain Therapy treatment.  
calmareaz.com
about 5 years ago
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Will my peripheral neuropathy get worse? -

With peripheral neuropathy, there is not a medical solution for a cure with inherited impaired function and nerve damage through inborn or a genetic mutation to the genetic code. Therapies can help with the identified 100 classifications of peripheral neuropathy. The nerve that is affected conveys the amount of systemic and decreased function a patient will display. Motor, autonomic, or sensory nerve damage carries different types of characteristics and the severity of symptoms experienced by the patient.  
calmareaz.com
about 5 years ago
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Korean MERS virus is not a mutation, say experts

Korean scientists have said that the virus causing the severe outbreak of Middle East respiratory syndrome in their country has not undergone significant mutation.  
feeds.bmj.com
over 5 years ago
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Genetics - Genetic testing and counselling - NHS Choices

Genetic testing can be used to find out whether a person is carrying a specific genetic mutation (altered gene) that causes a particular medical condition.  
nhs.uk
over 5 years ago
28977
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PMC3674777

DNA sequencing studies have established that many cancers contain tens of thousands of clonal mutations throughout their genomes, a fact which is difficult to reconcile with the very low rate of mutation in normal human cells. This observation provides strong evidence for the mutator phenotype hypothesis, which proposes that an elevation in the spontaneous mutation rate is an early step in carcinogenesis. An elevated mutation rate implies that cancers undergo continuous evolution and harbor multiple sub-populations of cells differing from one another in DNA sequence. The extensive heterogeneity in DNA sequence and continual tumor evolution that would occur in the context of a mutator phenotype have important implications for cancer diagnosis and therapy.  
ncbi.nlm.nih.gov
over 5 years ago
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Exercise for older mouse mothers lowers risk of heart defects in babies

In people, a baby's risk of congenital heart defects is associated with the age of the mother. Risk goes up with increasing age. Newborn mice predisposed to heart defects because of genetic mutations show the same age association. A new study demonstrates that older mouse mothers reduce this risk for their offspring to that of younger mouse mothers through exercise alone, according to researchers at Washington University School of Medicine in St. Louis.  
eurekalert.org
over 5 years ago
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Exercise for older mouse mothers lowers risk of heart defects in babies

In people, a baby's risk of congenital heart defects is associated with the age of the mother. Risk goes up with increasing age. Newborn mice predisposed to heart defects because of genetic mutations show the same age association. A new study demonstrates that older mouse mothers reduce this risk for their offspring to that of younger mouse mothers through exercise alone, according to researchers.  
sciencedaily.com
over 5 years ago
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Study finds new genetic clues to pediatric seizure disorders

Researchers have identified a new genetic mutation at the heart of a severe and potentially deadly seizure disorder found in infants and young children. The finding may help scientists unravel the complex biological mechanism behind these diseases. Epileptic seizures are the result of bursts of electrical activity in the brain caused when groups of neurons fire in an abnormal pattern.  
sciencedaily.com
over 5 years ago
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Detection of BRAF Mutations Through Cell Transfer Technique

Is cell transfer technique a reliable method for isolating tumor cells for ancillary BRAF mutation analysis?  
medscape.com
over 5 years ago
Nci 150417 test tubes cancer tumor 800x600
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EGFR Testing Not Done in 25% of Lung Cancer Patients

Not all patients with advanced NSCLC undergo testing for the EGFR mutation, and for some patients who do undergo testing, therapy is initiated before the results are received.  
medscape.com
over 5 years ago
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Gene variant and environment can boost severity of respiratory syncytial virus

A particular genetic mutation combined with an urban environment increases the risk of severe disease in children infected with respiratory syncytial virus (RSV), an international team of...  
medicalnewstoday.com
over 5 years ago
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Gene in high-altitude cattle disease sheds light on human lung disease

Vanderbilt University researchers have found a genetic mutation that causes pulmonary hypertension in cattle grazed at high altitude, and which leads to a life-threatening condition called...  
medicalnewstoday.com
over 5 years ago