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HIV: Mechanisms of PI Resistance

This animation describes how mutations in viral proteases can lead to resistance to PI drugs. Narrated by Dr. Mark Wainberg, Professor of Medicine and of Mic...  
YouTube
almost 6 years ago
U5cp5 1microevolutioncance ksm
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Cell Division, Cancer | Learn Science at Scitable

Cancer is somewhat like an evolutionary process. Over time, cancer cells accumulate multiple mutations in genes that control cell division. Learn how dangerous this accumulation can be.  
nature.com
over 5 years ago
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Medical Embryology Growth

Infertility, Fertilization, Ovulation, Spermatogenesis, Gene Mutations, Medical Pictures, Babies, Medical Terms, Cell Growth,  
medical-embryology.blogspot.ro
over 5 years ago
28977
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PMC3159000

Thrombotic thrombocytopenic purpura (TTP) is a disorder with characteristic von Willebrand factor (VWF)-rich microthrombi affecting the arterioles and capillaries of multiple organs. The disorder frequently leads to early death unless the patients are treated with plasma exchange or infusion. Studies in the last decade have provided ample evidence to support that TTP is caused by deficiency of a plasma metalloprotease, ADAMTS13. When exposed to high shear stress in the microcirculation, VWF and platelets are prone to form aggregates. This propensity of VWF and platelet to form microvascular thrombosis is mitigated by ADAMTS13, which cleaves VWF before it is activated by shear stress to cause platelet aggregation in the circulation. Deficiency of ADAMTS13, due to autoimmune inhibitors in patients with acquired TTP and mutations of the ADAMTS13 gene in hereditary cases, leads to VWF–platelet aggregation and microvascular thrombosis of TTP. In this review, we discuss the current knowledge on the pathogenesis, diagnosis and management of TTP, address the ongoing controversies, and indicate the directions of future investigations.  
ncbi.nlm.nih.gov
over 5 years ago
Www.bmj
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Genomic sequencing of only tumor tissue could be misleading in nearly half of patients, study shows

Clinicians who rely on genomic analysis of only a patient’s tumor tissue to guide cancer therapy could be misled by the presence of harmless mutations that are also present in the patient’s normal germline cells and are unrelated to the cancer, a study published in Science Translational Medicine has found.1  
feeds.bmj.com
over 5 years ago
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A high number of genomic mutations in advanced malignant plural mesothelioma revealed by targeted next-generation sequencing

Next generation sequencing in malignant pleural mesothelioma (MPM) tumors shows a complex mutational setting with a high number of genetic alterations in genes involved in DNA repair, cell...  
medicalnewstoday.com
over 5 years ago
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A high number of genomic mutations in advanced malignant plural mesothelioma identified by targeted next-generation sequencing

Next generation sequencing in malignant pleural mesothelioma (MPM) tumors shows a complex mutational setting with a high number of genetic alterations in genes involved in DNA repair, cell...  
medicalnewstoday.com
over 5 years ago
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It takes more than one cell mutation for asbestos exposure to lead to cancer

It has been a long held belief that tumors arising from exposure to asbestos are caused by mutations in one cell, which then produces multiple clones.  
medicalnewstoday.com
over 5 years ago
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Shape-shifting molecule tricks viruses into mutating themselves to death

A newly developed spectroscopy method is helping to clarify the poorly understood molecular process by which an anti-HIV drug induces lethal mutations in the virus's genetic material.  
medicalnewstoday.com
over 5 years ago
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Naturally acquired mutations in the avian H3N8 flu virus allow the infection to spread in mammals via respiratory droplets

A study led by St. Jude Children's Research Hospital scientists found the avian influenza A H3N8 virus that killed harbor seals along the New England coast can spread through respiratory...  
medicalnewstoday.com
over 5 years ago
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DNA blood test detects lung cancer mutations

Circulating tumor DNA in blood a valid option for EGFR testing in patients who do not have accessible tumor tissue, study showsCancer DNA circulating in the bloodstream...  
medicalnewstoday.com
over 5 years ago
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Study identifies genetic cause of increased leukemia risk

The discovery of a gene mutation that increases the risk of acute lymphoblastic leukemia, may help doctors to increase monitoring and to develop strategies to prevent the disease.  
medicalnewstoday.com
over 5 years ago
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Genomic profiling of gastric cancer identifies drug-targetable mutations

The majority of gastric cancers harbor genomic alterations (GAs) associated with potential benefit from targeted therapies, according to a new study published in The Oncologist.  
medicalnewstoday.com
over 5 years ago
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Scientists identify mutation associated with cleft palate in humans and dogs

Scientists studying birth defects in humans and purebred dogs have identified an association between cleft lip and cleft palate - conditions that occur when the lip and mouth fail to form...  
medicalnewstoday.com
over 5 years ago
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Novel Gene Important For Craniofacial Development Implicated In Facial Cleft Birth Defects

In the United States, a baby is born with a facial cleft every hour, of every day of the year! Such birth defects result from both gene mutations and environmental insults.  
medicalnewstoday.com
over 5 years ago
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Some Gene Mutations May Be Treatable With Diet

Scientists have moved a step closer to correcting some unhealthy gene mutations with diet, according to a new research report appearing in the April 2012 issue of the journal GENETICS.  
medicalnewstoday.com
over 5 years ago
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Singapore identifies mutations that may enable earlier diagnosis of colorectal cancer recurrence

The findings will be used to develop diagnostic kits for individual patients with colorectal cancer to detect future liver metastasisA multi-disciplinary team of...  
medicalnewstoday.com
over 5 years ago
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Hidden burden: Most people carry recessive disease mutations

New approach estimates the average number of mutations per person that cause disease when inherited from both parentsHumans carry an average of one to two mutations per...  
medicalnewstoday.com
over 5 years ago
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Researchers pin down genetic pathways linked to CF disease severity

New findings from the UNC School of Medicine may shed light on why cystic fibrosis patients with the same genetic mutation can have different disease severity and may react differently to...  
medicalnewstoday.com
over 5 years ago