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SGEM#116: Paramedics’ Got a Squeeze Box – Remote Ischemic Conditioning

Guest Skeptics: Clay Odell. Clay is a paramedic and Executive Director of Upper Valley Ambulance, a regional EMS system covering nine communities in rural New Hampshire and Vermont. He’s been involved in EMS for over 30 years in a variety of roles including urban paramedic, flight paramedic, an emergency nurse, and Chief of the State EMS Office in New Hampshire. Clay is very interested in EBM for EMS and says he’s trying really hard to learn, but continues to procrastinate about actually taking a statistics course again.  
thesgem.com
over 4 years ago
Www.bmj
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PET after chemotherapy identifies Hodgkin’s lymphoma patients who can avoid radiotherapy

Positron emission tomography (PET) scanning immediately after chemotherapy for Hodgkin’s lymphoma can identify patients who are likely to have good survival without radiotherapy, a study reported in the New England Journal of Medicine has found.1  
feeds.bmj.com
over 4 years ago
Medullary%20cycling1
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Physiology, Medullary Cycling and Amonium Trapping: Acid Base Tutorial, University of Connecticut Health Center

After ammoniagenesis, ammonium is taken up into the medullary interstitium via a process called medullary recycling. It is then pumped back into the tubular fluid at the level of the collecting duct, where it undergoes what is called ammonium trapping after which it is excreted.  
fitsweb.uchc.edu
over 4 years ago
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Ablation of pulmonary veins works as well as more extensive treatment in persistent atrial fibrillation, study finds

Extensive catheter ablation is no more effective than more targeted ablation to isolate the pulmonary veins in reducing the rate of recurrent atrial fibrillation in patients with persistent atrial fibrillation, a trial reported in the New England Journal of Medicine has found.1  
feeds.bmj.com
over 4 years ago
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Emergency cooling doesn’t improve outcomes in children with cardiac arrest, study shows

Therapeutic hypothermia, in which the whole body is cooled, does not improve survival or reduce brain injury any more than normal temperature control in infants and children who have had a cardiac arrest out of hospital, shows a study reported in the New England Journal of Medicine.1  
feeds.bmj.com
over 4 years ago
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New England Journal of Medicine reconsiders relationship with industry

In an editorial introducing a series of articles looking at the relationship between industry and academia, the New England Journal of Medicine’s editor, Jeffrey M Drazen, asks whether medical journals have made it too hard for researchers to write review articles and editorials.1  
feeds.bmj.com
over 4 years ago
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New England Journal of Medicine reconsiders relationship with industry

In an editorial introducing a series of articles looking at the relationship between industry and academia, the New England Journal of Medicine’s editor, Jeffrey M Drazen, asks whether medical journals have made it too hard for researchers to write review articles and editorials.1  
feeds.bmj.com
over 4 years ago
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Hospital practice explains variation in outcomes in extremely premature infants, US study finds

Much of the variation seen in outcomes among infants born at 22, 23, or 24 weeks of gestation can be explained by differences in hospitals’ practices on whether to initiate active treatment to save the lives of these extremely premature newborns, concludes a new study in the New England Journal of Medicine.1  
feeds.bmj.com
over 4 years ago
Www.bmj
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CPR before medical services arrive more than doubles survival after cardiac arrest

Giving cardiopulmonary resuscitation before emergency medical services arrive more than doubles the 30 day survival rate in people who have a cardiac arrest out of hospital, shows a Swedish study reported in the New England Journal of Medicine.1  
feeds.bmj.com
over 4 years ago
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Drug combination that corrects deficient protein in cystic fibrosis improves lung function

A combination of two drugs used to correct levels of the transmembrane protein that is defective or deficient in cystic fibrosis significantly improves patients’ lung function, show the results of two randomised studies published in the New England Journal of Medicine.1  
feeds.bmj.com
over 4 years ago
Www.bmj
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Drug combination that corrects deficient protein in cystic fibrosis improves lung function

A combination of two drugs used to correct levels of the transmembrane protein that is defective or deficient in cystic fibrosis significantly improves patients’ lung function, show the results of two randomised studies published in the New England Journal of Medicine.1  
feeds.bmj.com
over 4 years ago
Www.bmj
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Removing more tissue around breast tumour reduces need for further surgery

Removing additional tissue around the cavity left after excising a tumour during partial mastectomy in women with early breast cancer halves the rate of positive margins that require further surgery, a randomised study reported in the New England Journal of Medicine has shown.1  
feeds.bmj.com
over 4 years ago
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Dear NEJM: We both know that conflicts of interest matter.

0 Introduction 0 Recently the New England Journal of Medicine launched a media campaign challenging the negative perception of industry conflicts of intere  
pulmcrit.org
over 4 years ago
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Liraglutide improves weight loss in people who are overweight or obese, study shows

Liraglutide significantly reduces body weight and improves metabolic control in people who are obese or overweight and have dyslipidaemia or hypertension, a randomised trial reported in the New England Journal of Medicine has shown.1  
feeds.bmj.com
over 4 years ago
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Angioplasty with paclitaxel coated balloon reduces restenosis in peripheral artery disease

Percutaneous transluminal angioplasty using a paclitaxel coated balloon notably improves arterial patency at one year when compared with the same procedure using a standard uncoated balloon in patients with femoropopliteal artery disease, a study in the New England Journal of Medicine has shown.1  
feeds.bmj.com
over 4 years ago
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Antiretroviral therapy for HIV should be started at diagnosis regardless of CD4+ count, study concludes

Initiating antiretroviral therapy immediately after HIV diagnosis rather than waiting until a patient’s CD4+ count has declined is of considerable benefit, a large international study published in the New England Journal of Medicine has found.1 The results of the study were also released at the International AIDS Society conference in Vancouver, Canada, on 20 July.  
feeds.bmj.com
over 4 years ago
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Assessment of Clinical Skills of Residents Utilizing Standardized Patients: A Follow-up Study and Recommendations for Application | Annals of Internal Medicine

The following institutions cooperated in this project: Beth Israel Hospital, Boston, Massachusetts; Boston City Hospital, Boston, Massachusetts; Brigham and Women's Hospital, Boston, Massachusetts; Baystate Medical Center, Springfield, Massachusetts; Hartford Hospital, Hartford, Connecticut; Memorial Hospital, Pawtucket, Rhode Island; Memorial Hospital, Worcester, Massachusetts; Mount Auburn Hospital, Cambridge, Massachusetts; New England Medical Center, Boston, Massachusetts; Rhode Island Hospital, Providence, Rhode Island; St. Vincent Hospital, Worcester, Massachusetts; University Hospital, Boston, Massachusetts; University of Massachusetts Medical Center, Worcester, Massachusetts; Worcester City Hospital, Worcester, Massachusetts; and Veterans Affairs Medical Center, Boston, Massachusetts.  
annals.org
over 4 years ago
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Medical Statistics and Medical Errors, Part I

The field of medical statistics is poorly understood by many doctors and by most patients. An article in the New England Journal of Medicine that surveyed over 100 articles published in reputable medical journals stated that over 50% of them used medical statistics incorrectly, and furthermore stated that this misuse invalidated the clinical conclusions of many of these articles. In this blog I will not discuss esoterica such as when to use a two-tailed t-test rather than a one-tailed test, or the uses and misuses of the Cox regression analysis. Instead I will try to point out fallacies in reasoning and statistics that should cause you to doubt a result quoted in the journal or in the newspapers.  
ghthomas.blogspot.co.uk
over 4 years ago