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Pesticide exposure contributes to heightened risk of heart disease

Pesticide exposure, not obesity alone, can contribute to increased cardiovascular disease risk and inflammation in premenopausal women, according to a new study.  
sciencedaily.com
almost 5 years ago
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Older people can learn to spend less time sitting down

Older adults spend 8.5 waking hours a day sitting or lying down -- time linked to obesity, heart disease, diabetes, and death -- even if they're physically active at other times. A new study showed it was feasible to coach older people to spend less time sitting: an average of a half hour less per day. They reported feeling more able to accomplish everyday tasks -- and they walked faster and had fewer depression symptoms.  
sciencedaily.com
almost 5 years ago
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Older people can learn to spend less time sitting down

Older adults spend 8.5 waking hours a day sitting or lying down -- time linked to obesity, heart disease, diabetes, and death -- even if they're physically active at other times. A new study showed it was feasible to coach older people to spend less time sitting: an average of a half hour less per day. They reported feeling more able to accomplish everyday tasks -- and they walked faster and had fewer depression symptoms.  
eurekalert.org
almost 5 years ago
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3 Real Contributors to the Obesity Epidemic

We're in the midst of an obesity epidemic that is contributing to chronic disea...  
huffingtonpost.com
almost 5 years ago
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Dr Jason Fung on the impact of diet on obesity and type 2 diabetes mellitus

Stream Dr Jason Fung on the impact of diet on obesity and type 2 diabetes mellitus by BMJ talk medicine from desktop or your mobile device  
feeds.bmj.com
almost 5 years ago
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Recent advances in clinical practice challenges and opportunities in the management of obesity

Stream Recent advances in clinical practice challenges and opportunities in the management of obesity by BMJ talk medicine from desktop or your mobile device  
feeds.bmj.com
almost 5 years ago
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Exercise 'not key to obesity fight' - BBC News

Physical activity has little role in tackling obesity - and instead public health messages should squarely focus on unhealthy eating, doctors say.  
bbc.co.uk
almost 5 years ago
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MelCap Electronic Pill to Help Treat Obesity, Eating Disorders |

MelCap Systems is an Israeli firm that may offer a new way of treating obesity and other eating conditions using a swallowable electronic pill. The technol  
medgadget.com
almost 5 years ago
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Exercise 'not key to obesity fight' - BBC News

Physical activity has little role in tackling obesity - and instead public health messages should squarely focus on unhealthy eating, doctors say.  
bbc.co.uk
almost 5 years ago
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BioMed Notes

Obesity in humans is associated with a region around FTO, a "fat mass and obesity-associated” gene on chromosome 16. Although this is the strongest genetic association, it accounts for only a 1-2% difference in Body Mass Index (BMI) and the mechanism was unknown. Here, the investigators looked at regulator proteins binding to variants DNA sequences within the FTO region, particularly those binding to sites with single nucleotide polymorphisms (SNPs), in 100 healthy Europeans -- 52 subjects were homozygous for 3 risk-variant SNPs (both alleles, all 3 loci) and the remaining 48 were homozygous for the non-risk variants. They found that the change of a T-to-C at one SNP within a risk allele of FTO prevented the binding of the repressor protein ARID5B. For want of this binding site, the repressor is lost. For want of this repressor, the expression of 2 linked genes doubles: IRX3, located about half a million base pairs (~0.5 Mbp) away, and IRX5, ~1 Mbp away. IRX3 repression made mice thinner by “increased energy dissipation without a change in physical activity or appetite”, i.e. not changing eating or exercise but rather elevating ‘metabolism’. The doubled expression of IRX3 led to a 5-fold reduction in mitochondrial thermogenesis and a 7-fold difference in brown/white adipose tissue development.  (Brown fat is brown because it holds more mitochondria, little furnaces that burn fat and produce heat.) The risk alleles are causative, and mediate through IRX3 and IRX5, because mimicking the repression of IRX3 or IRX5 in 8 carriers of the risk alleles, but not 10 carriers of the non-risk allele increased stimulated metabolism (Fig 3D, shown, left panel). And overexpression of IRX3 or IRX5 reduced stimulated metabolism in non-risk allele carriers (because their endogenous genes are repressed) but not in risk allele carriers (Fig 3D, right panel). Figure 3D. Oxygen consumption rate (OCR), basal and stimulated, in cells with risk or non-risk alleles. The take-home messages are that the causative SNP can be kilobases away from the genes that mediate the effect (not a huge surprise) and that small risks might develop from relatively big differences in particular developmental and cell biological pathways (reverse butterfly effect: not small-change-to-big-effect but big effect leads to small change (1-2% BMI)). N Engl J Med. 2015 Sep 3;373(10):895-907. “FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.” Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M  
biomednotes.blogspot.co.uk
over 4 years ago
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Obesity 'was a factor' in death of 18 year old - BBC News

Satish Appleby speaks about the death of her overweight son.  
bbc.co.uk
over 4 years ago
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Will new Indian growth charts help stem the rise in childhood obesity?

New body mass index charts for children in India have the same overweight and obesity cut-off points as for adults, but not everyone agrees that they will help, writes Manupriya  
feeds.bmj.com
over 4 years ago
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Drug dosing in obesity – Don't Forget the Bubbles

Obese and overweight children are on the increase. A common area of confusion is – how we are supposed to calculate their medications given their weight?  
dontforgetthebubbles.com
over 4 years ago
Www.bmj
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Tax processed food to subsidise healthier options and tackle obesity, says think tank

The tendency for common processed foods such as crisps and biscuits to become cheaper over the past 30 years, while fruit and vegetables have become more expensive, is driving the obesity epidemic, a think tank has said. It recommends that governments consider introducing taxes on unhealthy foods and use these to subsidise other food groups.  
feeds.bmj.com
over 4 years ago
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Drug maker must restart obesity drug study after releasing early data

A major US study of a newly approved antiobesity drug that was designed to measure adverse cardiovascular effects has been stopped by its steering committee after the manufacturer revealed first quarter data in a patent application.  
feeds.bmj.com
over 4 years ago
Www.bmj
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Teenage obesity is linked to bowel cancer in later life

Being obese as a teenager may double the risk of developing bowel cancer in middle age, research published in the journal Gut has shown.  
feeds.bmj.com
over 4 years ago
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Diabetes is rising in OECD countries, report warns

Deaths from cardiovascular disease have fallen by over 60% in the past 50 years in the Organisation for Economic Cooperation and Development (OECD) member states, but rising levels of obesity and diabetes threaten the prospects of further improvement, a new report warns.  
feeds.bmj.com
over 4 years ago
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Diabetes is rising in OECD countries, report warns

Deaths from cardiovascular disease have fallen by over 60% in the past 50 years in the Organisation for Economic Cooperation and Development (OECD) member states, but rising levels of obesity and diabetes threaten the prospects of further improvement, a new report warns.  
feeds.bmj.com
over 4 years ago
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Diabetes is rising in OECD countries, report warns

Deaths from cardiovascular disease have fallen by over 60% in the past 50 years in the Organisation for Economic Cooperation and Development (OECD) member states, but rising levels of obesity and diabetes threaten the prospects of further improvement, a new report warns.  
feeds.bmj.com
over 4 years ago
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Accelerating the translation of digital health obesity treatments

Gary G. Bennett, PhD and Director of Duke Obesity Prevention Program.  
youtube.com
over 4 years ago