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Pharmacokinetics

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Acetaminophen & Salicylate Toxicity with Dr. Bosse

Dr. George Bosse gives a thorough review of acetaminophen and salicylic acid pharmacokinetics followed by presenting symptoms, pathology and treatments for t...  
youtube.com
over 4 years ago
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26

A Foundation for Neonatal Care

This authoritative guide offers a vital overview including the recent fundamental changes in the care of newborn babies. As well as medical staff, key roles are now played by senior nurses, clinical nurse specialists, pharmacists, advanced neonatal nurse practitioners, nurse consultants, midwives, dieticians, physiotherapists and speech therapists. The involvement of such a diverse range of professional cultures in such a rapidly developing area often leads to competing priorities, complicated by a lack of established guidelines. There is also the added challenge of fetal medicine - an important emerging allied specialty new to many healthcare professionals. This book assists all professionals involved in the provision of neonatal care in understanding the genetic, physiological and biochemical mechanisms which have either led to or are associated with the clinical conditions affecting their patients. With comprehensive chapters on fetal medicine, genetics, inherited biochemical disorders, fundamental physiological concepts, the cardiovascular, renal and respiratory systems, bacterial and transplacental infections, pharmacokinetics, nutrition, and an overview of haemostasis, A Foundation For Neonatal Care aids understanding of the continuum of developmental physiology and pathology which is now required of neonatal care providers.  
books.google.co.uk
over 4 years ago
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29

Critical Care

We agree with the recent commentary of Gonçalves-Pereira and Oliveira refuting a ‘one size fits all’ paradigm of antibiotic dosing in patients subjected to extracorporeal circulation [1] but want to focus somewhat further on meropenem pharmacokinetics (PK).  
ccforum.com
over 4 years ago
Www.bmj
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The secret realm of phase I trials in healthy volunteers

Phase I clinical trials in healthy volunteers aim at establishing safety, pharmacokinetics, and dosage for subsequent testing of new drugs. They are a necessary step in building the evidence for new treatments. But many view them with suspicion. Phase I trials expose humans to unproved drugs—often at plasma concentrations needed for detecting toxicity. Because volunteers are healthy, the ratio of medical risk to benefit for them is almost infinite. Another reason for suspicion is that healthy volunteers are paid—a fact that makes it likely that primary motivations for participation are misaligned with those of researchers,1 and that study participants will be drawn from underemployed people.  
feeds.bmj.com
over 4 years ago
941160a7acd183072e7c61820af432a7966cc52d7131987142796123
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Drugs use in Diabetes

An overview of the drugs used in Diabetes.  
Kristian Dye
almost 4 years ago
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7

Morphine Delays, Attenuates Ticagrelor in Patients With MI

This study assessed the effect of IV morphine on the pharmacokinetics and pharmacodynamics of ticagrelor in the setting of acute MI.  
medscape.com
almost 4 years ago
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CORE EM: Pharmacology of Insulins - emdocs

Insulin was first licensed for human use in 1922. Since then, numerous formulations with various similar names have been produced and marketed. Because the names of the different drugs are often very similar (novolin vs novalog) it can difficult for emergency providers to keep all of the agents straight. In this post, we discuss the categories of insulins, the nomenclature and the pharmacokinetics of the most commonly used agents.  
emdocs.net
over 3 years ago
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Seeing Nanoparticles in 3D Within Animal Tissues |

Understanding the pharmacokinetics and distribution of nanoparticles has always been challenging. Researchers can quantify accumulation at the organ level,  
medgadget.com
over 3 years ago