Psoriasis

Pictures of dermatological conditions on the undergraduate syllabus including acute and chronic wounds, eczema, psoriasis and more.  

 

A informative document about psoriasis including the histology, epidemiology, triggers, types and treatment of the condition.  

for medical students: what you need to know, from skin basics to treatment in psoriasis and melanoma, managing uncertainty  

Psoriasis is an autoimmune condition which affects the skin and joints. It is sometimes referred to as one of the spondyloarthritides (inflammatory arthritis that is seronegative for rheumatoid factor (and/or does not fit the criteria for diagnosis as RA)).   Definitions  

Pathology Keratinocyte hyperproliferation: differentiation, or ‘skin cell going from basal layer to horny layer’, reduced from 4 weeks to 4 days [approximately!] Histopathological features: Parakeratosis: retained nuclei Acanthosis: thick epidermis Absent granular layer Lengthened rete ridges Thin dermal papillae  

Dimethyl fumerate has a chequered history⇑. It was banned as an industrial fungicide in the late 1990s, after furniture impregnated with fumarate caused outbreaks of serious allergic eczema. However, it remains an effective treatment for psoriasis when …  

“Psoriatic arthritis with distal joint involvement in the third and fifth digits (arrow). Onycholysis is also seen in most of the fingernails.”  

“Nail pits in psoriasis: Numerous pits are present on the nail of this patient with psoriasis”  

“Psoriatic arthritis X-ray of the wrist of a patient with psoriatic arthritis; note the 'pencil in cup' deformity (tapered proximal osseous surface and…”  

Synonyms: psoriatic arthropathy, arthropathia psoriatica, arthritis mutilans, seronegative arthritis associated with psoriasis See also separate articles...  

Objective To evaluate the relative risk of pulmonary disease among patients with psoriasis, psoriatic arthritis, and inflammatory bowel disease treated with methotrexate.  

Objective To evaluate the relative risk of pulmonary disease among patients with psoriasis, psoriatic arthritis, and inflammatory bowel disease treated with methotrexate.  

Objective To evaluate the relative risk of pulmonary disease among patients with psoriasis, psoriatic arthritis, and inflammatory bowel disease treated with methotrexate.  

Objective To evaluate the relative risk of pulmonary disease among patients with psoriasis, psoriatic arthritis, and inflammatory bowel disease treated with methotrexate.  

I have heard that sunlight can be helpful for psoriasis, yet the other day I heard someone I know say that it makes their's worse. I got quite confused and couldn't understand if it makes it better, worse or does it depend? Can anyone explain to me please?  

A 42 year old man develops a sore throat. He does not consult his GP but takes some over the counter painkillers and an anti-inflammatory. 1 week later he has a non itchy rash starting on his feet then spreading to his trunk. The rash has the appearance of tiny teardrops. He is correctly diagnosed with guttate psoriasis. The patient is put on penicillin orally 250mg QDS for 1 week. He then starts passing small volumes of urine. His urine is described as "orangey brown" . He continues taking a non steroidal anti inflammatory drug (ibuprofen 800mg TDS). What is the most likely explanation for this? a. Post infective glomerulonephritis b. Rheumatic fever c. Secondary to penicillin d. Interstitial nephritis secondary to anti inflammatory medication  

Objective To evaluate the relative risk of pulmonary disease among patients with psoriasis, psoriatic arthritis, and inflammatory bowel disease treated with methotrexate.  

Celgene Corporation has announced that results from long-term efficacy and safety analyses of the ESTEEM phase III clinical trial program of Otezla® (apremilast) were presented at the 73rd...