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Radiotherapy

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Seven days in medicine: 30 January to 5 February

Proton beam therapy is effective Proton beam therapy achieves similar survival to conventional photon radiotherapy in children with medulloblastoma and may be less toxic, a prospective study reported. Only 16% of children who had the more targeted proton therapy had significant hearing loss at five years, compared with 24-25% who had photon therapy, and they showed less cognitive deficit. Progression-free survival at five years was 80%, and overall survival was 83%—both similar to the results with conventional radiotherapy. (See The BMJ’s full story at doi:10.1136/bmj.i608.)  
feeds.bmj.com
over 3 years ago
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Seven days in medicine: 30 January to 5 February

Proton beam therapy is effective Proton beam therapy achieves similar survival to conventional photon radiotherapy in children with medulloblastoma and may be less toxic, a prospective study reported. Only 16% of children who had the more targeted proton therapy had significant hearing loss at five years, compared with 24-25% who had photon therapy, and they showed less cognitive deficit. Progression-free survival at five years was 80%, and overall survival was 83%—both similar to the results with conventional radiotherapy. (See The BMJ’s full story at doi:10.1136/bmj.i608.)  
feeds.bmj.com
over 3 years ago
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Proton Beam in Medulloblastoma: 'New Benchmark'

In children with medulloblastoma, proton-beam therapy has survival rates similar to standard radiotherapy, but fewer systemic toxicities.  
medscape.com
over 3 years ago
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Predictors of Inappropriate Radiotherapy for Lung Cancer

Are patients with metastatic lung cancer receiving more radiation fractions than recommended?  
medscape.com
over 3 years ago
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DCIS Prognostic Score Associated With Radiotherapy Survival Benefit

A simple prognostic score identifies women with ductal carcinoma in situ (DCIS) who will derive a survival benefit from radiotherapy after breast-conserving therapy, according to a longitudinal study.  
medscape.com
over 3 years ago
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Which Women With DCIS Can Forgo Radiotherapy?

A prognostic scoring system identifies patients with DCIS who may have improved survival with radiation after lumpectomy, and suggests that a substantial number of patients may not need radiation.  
medscape.com
over 3 years ago
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Ablative Radiotherapy in Intrahepatic Cholangiocarcinoma

Higher doses of radiotherapy may improve local control and overall survival in patients with inoperable intrahepatic cholangiocarcinoma.  
medscape.com
over 3 years ago
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Radiation-Induced Valvular Heart Disease

How prevalent is radiation-induced valvular disease following mediastinal radiotherapy? How should it be managed--and can the risk be reduced?  
medscape.com
over 3 years ago
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'Risky': Prostate Radiation, Second Cancers Linked

The absolute risks are low but there are notably increased relative risks for secondary cancers after radiotherapy for prostate cancer.  
medscape.com
over 3 years ago
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A (relatively) risky business: the link between prostatic radiotherapy and second malignancies

There is a well recognized association between exposure to radiation and carcinogenesis.1 The development of second malignancies after therapeutic radiation depends on the primary malignancy, the dose to tissues at risk, and specific characteristics of the patient.2 There is a strong association between radiotherapy and second malignancies in people with Hodgkin’s lymphoma3 4 and patients with other cancers treated with radiotherapy.5 6 Data linking radiotherapy for prostate cancer and subsequent malignancy have been less clear. Defining such a link has been difficult because the population is older and has a limited natural lifespan with prominent competing health risks. In addition, the relatively small number of outcomes in these analyses limits their statistical validity. Previous systematic reviews and one small meta-analysis reported inconsistent conclusions.7 8 9  
feeds.bmj.com
over 3 years ago
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Second malignancies after radiotherapy for prostate cancer: systematic review and meta-analysis

Objective To determine the association between exposure to radiotherapy for the treatment of prostate cancer and subsequent second malignancies (second primary cancers).  
feeds.bmj.com
over 3 years ago
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Don't Abandon Radiation, It Improves Survival in DLBCL

Large national US database supports a survival advantage for consolidation radiotherapy following chemotherapy over chemotherapy alone in early, diffuse, large B-cell lymphoma.  
medscape.com
over 3 years ago
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Second malignancies after radiotherapy for prostate cancer: systematic review and meta-analysis

Objective To determine the association between exposure to radiotherapy for the treatment of prostate cancer and subsequent second malignancies (second primary cancers).  
feeds.bmj.com
over 3 years ago
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Brain Metastases: Two Radiosurgery Techniques Compared

Two advanced radiosurgery approaches, the Gamma Knife and RapidArc, are equally effective at eradicating brain metastases.  
medscape.com
over 3 years ago
Www.bmj
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Partial breast radiotherapy is as effective as standard whole breast radiotherapy, study finds

Radiotherapy focused around only the part of the breast that had contained the tumour is as effective as the standard treatment of whole breast radiotherapy, shows research presented at the European Breast Cancer Conference in Amsterdam this week.1 The researchers hope that the results will contribute to changes in clinical practice worldwide.  
feeds.bmj.com
over 3 years ago
Www.bmj
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Partial breast radiotherapy is as effective as standard whole breast radiotherapy, study finds

Radiotherapy focused around only the part of the breast that had contained the tumour is as effective as the standard treatment of whole breast radiotherapy, shows research presented at the European Breast Cancer Conference in Amsterdam this week.1 The researchers hope that the results will contribute to changes in clinical practice worldwide.  
feeds.bmj.com
over 3 years ago
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Brief Androgen Suppression Plus Radiotherapy for Prostate Cancer

For men with intermediate- or high-risk localized prostate cancer, six months of androgen suppression (AS) plus radiotherapy (RT) significantly improved biochemical and clinical disease-free survival compared with RT alone in the EORTC trial 22991.  
medscape.com
over 3 years ago
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Second Malignancies After Radiotherapy for Prostate Cancer

Might irradiation of the prostate contribute to secondary cancers of other organs, such as bladder, colon, lung, and rectum?  
medscape.com
over 3 years ago
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Does Radiotherapy for PCa Cause Secondary Cancers?

A meta-analysis on the association of radiotherapy for prostate cancer and development of second primary malignancies may have important implications, says Dr Gerald Chodak.  
medscape.com
over 3 years ago
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Cranial Irradiation in EGFR-Mutant NSCLC Brain Metastases

Is erlotinib plus radiotherapy superior to either therapy alone for brain metastases associated with NSCLC?  
medscape.com
over 3 years ago