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Climate Change Threatens Hearts, Lungs But Also Brains - U.S. Study

Climate change can be expected to boost the number of annual premature U.S. deaths from heat waves in coming decades and to increase mental health problems from extreme weather like hurricanes and floods, a U.S. study said on Monday.  
medscape.com
over 4 years ago
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Mixed Message on Sleep Apnea Treatment Effect in Diabetes

Two studies come to differing conclusions about the impact of continuous positive airway pressure on glycemia in patients with both obstructive sleep apnea and type 2 diabetes.  
medscape.com
over 4 years ago
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Negative Pressure Pulmonary Edema in an Eye Care Setting

This unusual case of NPPE in an otherwise healthy patient highlights the need for intensive care facilities in any health care setting--including eye care--where general anesthesia is performed.  
medscape.com
over 4 years ago
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Will Hyperpolarized Noble Gas MRI Revolutionize Lung Imaging?

Hyperpolarized noble gas MRI marks the next wave of lung imaging innovation.  
medscape.com
over 4 years ago
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Translating Lung Cancer Screening Guidelines Into Practice

New lung cancer screening guidelines, as implemented at one community hospital, resulted in a much higher number of follow-ups than anticipated.  
medscape.com
over 4 years ago
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1069

Asthma: Definition, Aetiology, Clinical Features, Diagnosis and Managment

This is "Asthma" by pulsenotes on Vimeo, the home for high quality videos and the people who love them.  
vimeo.com
over 4 years ago
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Lab Case 98 – Interpretation

Expected HCO3 for acute compensated respiratory alkalosis would be 21, actual HCO3 is 18.6 which suggests an additional metabolic acidosis. The low CO2 suggests this an acute respiratory disorder, with a chronic respiratory alkalosis you would expect a CO2 closer to normal with a near normal pH. It is unlikely a patient would have a very rapid respiratory rate for a prolonged period.  
emergucate.com
over 4 years ago
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New and emerging targeted therapies for cystic fibrosis

Cystic fibrosis (CF) is a monogenic autosomal recessive disorder that affects about 70 000 people worldwide. The clinical manifestations of the disease are caused by defects in the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The discovery of the CFTR gene in 1989 has led to a sophisticated understanding of how thousands of mutations in the CFTR gene affect the structure and function of the CFTR protein. Much progress has been made over the past decade with the development of orally bioavailable small molecule drugs that target defective CFTR proteins caused by specific mutations. Furthermore, there is considerable optimism about the prospect of gene replacement or editing therapies to correct all mutations in cystic fibrosis. The recent approvals of ivacaftor and lumacaftor represent the genesis of a new era of precision medicine in the treatment of this condition. These drugs are having a positive impact on the lives of people with cystic fibrosis and are potentially disease modifying. This review provides an update on advances in our understanding of the structure and function of the CFTR, with a focus on state of the art targeted drugs that are in development.  
feeds.bmj.com
over 4 years ago
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New and emerging targeted therapies for cystic fibrosis

Cystic fibrosis (CF) is a monogenic autosomal recessive disorder that affects about 70 000 people worldwide. The clinical manifestations of the disease are caused by defects in the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The discovery of the CFTR gene in 1989 has led to a sophisticated understanding of how thousands of mutations in the CFTR gene affect the structure and function of the CFTR protein. Much progress has been made over the past decade with the development of orally bioavailable small molecule drugs that target defective CFTR proteins caused by specific mutations. Furthermore, there is considerable optimism about the prospect of gene replacement or editing therapies to correct all mutations in cystic fibrosis. The recent approvals of ivacaftor and lumacaftor represent the genesis of a new era of precision medicine in the treatment of this condition. These drugs are having a positive impact on the lives of people with cystic fibrosis and are potentially disease modifying. This review provides an update on advances in our understanding of the structure and function of the CFTR, with a focus on state of the art targeted drugs that are in development.  
feeds.bmj.com
over 4 years ago
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1

New and emerging targeted therapies for cystic fibrosis

Cystic fibrosis (CF) is a monogenic autosomal recessive disorder that affects about 70 000 people worldwide. The clinical manifestations of the disease are caused by defects in the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The discovery of the CFTR gene in 1989 has led to a sophisticated understanding of how thousands of mutations in the CFTR gene affect the structure and function of the CFTR protein. Much progress has been made over the past decade with the development of orally bioavailable small molecule drugs that target defective CFTR proteins caused by specific mutations. Furthermore, there is considerable optimism about the prospect of gene replacement or editing therapies to correct all mutations in cystic fibrosis. The recent approvals of ivacaftor and lumacaftor represent the genesis of a new era of precision medicine in the treatment of this condition. These drugs are having a positive impact on the lives of people with cystic fibrosis and are potentially disease modifying. This review provides an update on advances in our understanding of the structure and function of the CFTR, with a focus on state of the art targeted drugs that are in development.  
feeds.bmj.com
over 4 years ago
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Cost-Effectiveness of Antiviral Treatment for Influenza A

Is antiviral treatment based on a rapid point-of-care test for influenza A a cost-effective treatment method?  
medscape.com
over 4 years ago
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R.E.B.E.L. EM - Is Too Much Supplemental O2 Harmful in COPD Exacerbations? - emdocs

Does hyperoxia suppress a COPD patient’s respiratory drive? Does it cause V/Q mismatching? Does it change the chemistry of the patient’s blood through the Haldane effect? It’s enough to make you want to give up and page respiratory therapy. Well lucky for you we sifted through the primary literature to bring you the myths and facts, and the short answer is…it’s complicated.  
emdocs.net
over 4 years ago
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Efficacy and Safety of Corticosteroids in Pneumonia

Although widely used, is there an actual benefit to using a short course of systemic corticosteroids in community-acquired pneumonia?  
medscape.com
over 4 years ago
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Which vessel is a posterior relation of the right main bronchus?

This video is part of a playlist of short videos which are intended to combine multiple choice questions' answering experience with an improved understanding...  
youtube.com
over 4 years ago
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People With Sleep Apnea More Likely to Get Injured at Work

Obstructive sleep apnea, which wakes people many times a night, could also raise the risk of getting hurt during the day at work, a small Canadian study suggests.  
medscape.com
over 4 years ago
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Combined Surgical Approach Effective for Severe Sleep Apnea

For adults with severe obstructive sleep apnea (OSA), combined coblation endoscopic lingual lightening (CELL) and relocation pharyngoplasty yields better outcomes than relocation pharyngoplasty alone.  
medscape.com
over 4 years ago
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Low-Dose CT Lung Cancer Screening Programs in the U.S.

What are the biggest challenges to implementing low-dose CT lung cancer screening programs in the United States?  
medscape.com
over 4 years ago
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Imaging Case of the Week 197 Answer

The chest x-ray shows a widened mediastinum with a lack of delineation of the aortic knuckle. The left main bronchus appears depressed.  
emergucate.com
over 4 years ago