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RespiratorySystem

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Nasal Mucosa Graft to Deliver Drugs Through Blood-Brain Barrier |

As is well known, the blood-brain barrier is a strict checkpoint that prevents variety of drugs from reaching the brain. At the Massachusetts Eye and Ear/H  
medgadget.com
almost 5 years ago
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Testing antibiotics in combination for acute infections of Pseudomonas aeruginosa in cystic fibrosis | Cochrane

The main cause of death in people with cystic fibrosis is due to chronic lung infection. People with cystic fibrosis now live longer due to the aggressive use of antibiotics to treat lung infections. Traditionally, antibiotics are chosen based on the results of laboratory testing of each antibiotic separately against the bacterium (or bug) that is found in the lungs of someone with cystic fibrosis. Antibiotics tested in combination may have activity against a bacterium even if ineffective when tested alone. It is unclear, however, if choosing antibiotics to treat lung infections caused by Pseudomonas aeruginosa (P. aeruginosa) in people with cystic fibrosis, based on the results of testing antibiotics in combination is better than choosing antibiotics based on the results of testing antibiotics separately.  
cochrane.org
almost 5 years ago
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Fewer Mycophenolate Adverse Events in Scleroderma Lung Study

Results from the first clinical trial comparing mycophenolate with cyclophosphamide suggest that treatment options for scleroderma-related interstitial lung disease are expanding.  
medscape.com
almost 5 years ago
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Depression Common in Patients Awaiting Lung Transplant

More than half of patients waiting for a lung transplant suffered from psychologic stress in a new study, which might be serious enough to affect transplant outcomes.  
medscape.com
almost 5 years ago
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Mannitol, an inhaled drug, for treating lung disease in cystic fibrosis | Cochrane

Cystic fibrosis is a genetic disorder that affects the exocrine glands (sweat glands and others). Lung infections produce thick mucus (phlegm) which can block air passages and cause more infection and repeated inflammation. In turn, this progressively damages the lungs and can eventually cause respiratory failure. There are several drugs that are used to clear mucus from the airways of people with cystic fibrosis and inhaled dry powder mannitol is a new one that may improve their lung function. The dry powder formulation of mannitol may be more convenient and easier to use compared with established agents which are delivered by a nebuliser (e.g. hypertonic saline).  
cochrane.org
almost 5 years ago
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Collapse of Right Lung Apex

Prepare for USMLE,UK,CANADIAN,AUSTRALIAN, NURSING & OTHER MEDICAL BOARD examinations around the globe with us.Understand the basics, concepts and how to answ...  
youtube.com
almost 5 years ago
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Episode 35 – The Trachea

Source: Episode 35 – The Trachea  
prehospitalmed.com
almost 5 years ago
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Breathing training before surgery for reducing lung complications after surgery in adults undergoing heart and major abdominal surgery | Cochrane

Despite advances regarding patient care in the last few decades, breathing complications as a result of lung injury after surgery such as pneumonia are the leading cause of sickness and death in adults undergoing heart and major abdominal surgery. Training of breathing muscles using a small device at home before surgery seems to make breathing easier and helps strengthen muscles of respiration after surgery. This training may help reduce breathing complications after surgery and may lead to improved patient care and overall health care cost savings for the public health system. We wanted to establish whether training of breathing muscles before surgery can reduce the risk of lung complications and to identify who in particular might benefit from such training.  
cochrane.org
almost 5 years ago
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Genetic Basis for Poor Lung Function Identified

An international research group identified novel genetic causes for poor lung function and shared genetic causes of obstructed airflow, regardless of whether people never smoked or smoked heavily.  
medscape.com
almost 5 years ago
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Everolimus First Drug to Show Effect in Lung NETs

Already approved for use in pancreatic neuroendocrine tumors (NETs), the drug now shows efficacy in tumors originating in lung and gastrointestinal tract.  
medscape.com
almost 5 years ago
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Drugs to dissolve pulmonary embolism (blood clot in the lungs) | Cochrane

A pulmonary embolism is a potentially fatal blood clot that lodges in the main artery of the lungs, straining the right side of the heart and affecting blood circulation. Patients are also at risk of new embolisms forming (recurrence). In the case of a massive pulmonary embolism, treatment to restore blood flow is urgently required. Heparin thins the blood, but newer drugs that actively break up the clots (thrombolytics) may act more quickly and be more effective. These newer drugs include streptokinase, urokinase and recombinant tissue-type plasminogen activator. The major complication of this treatment is bleeding.  
cochrane.org
almost 5 years ago
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Inhibitor Slows Lung Decline in Inherited Emphysema

Replacement therapy can lessen lung decline in patients with alpha-1 antitrypsin deficiency who develop emphysema, and might be of benefit to emphysema patients without the genetic disorder.  
medscape.com
almost 5 years ago
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Rare 'healthy' smokers' lungs explained - BBC News

The mystery of why some people appear to have healthy lungs despite a lifetime of smoking has been explained by scientists.  
bbc.co.uk
almost 5 years ago
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Surgery Boosts Survival Chances for Advanced Throat Cancer

Surgery significantly improves survival among patients with advanced oropharyngeal and hypopharyngeal cancers, registry data show.  
medscape.com
almost 5 years ago
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Is it possible to decrease MRSA carriage by putting antibiotics in your nose?

It is estimated that up to 15-30% of the human population in developed countries are colonized by the community acquired strains of methicillin resistant staph aureus. The risk of developing a skin infection in the year following discovery of colonized status is approximately 1-in-4. Autoinfection rates are between 76-86% – thus most people that get MRSA infections get it from themselves.  
pemcincinnati.com
almost 5 years ago
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APRV Lung Demonstration | Resus Review

Unlike spontaneous breathing or conventional ventilation, the time spent at maximal inflation is typically much longer than time deflated. Time low is minimized to prevent collapse of alveoli and barotrauma. The video below shows shows treated pig lungs being ventilated with typical APRV settings.  
charlesbruen.wpengine.com
almost 5 years ago
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Critical Care

Ventilator settings resulting in decreased driving pressure (ΔP) are positively associated with survival. How to further foster the potential beneficial mediator effect of a reduced ΔP? One possibility is promoting the active modification of the lung’s “mechanical scenario” by means of lung recruitment and positive end-expiratory pressure selection. By taking into account the individual distribution of the threshold-opening airway pressures to achieve maximal recruitment, a redistribution of the tidal volume from overdistended to newly recruited lung occurs. The resulting more homogeneous distribution of transpulmonary pressures may induce a relief of overdistension in the upper regions. The gain in lung compliance after a successful recruitment rescales the size of the functional lung, potentially allowing for a further reduction in ΔP.  
ccforum.com
almost 5 years ago
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Virtual reality training for improving the skills needed for performing surgery of the ear, nose or throat | Cochrane

This review evaluated whether surgeons trained in virtual reality simulation achieved outcomes for their patients that were equivalent to, or better than, those obtained through conventional training methods. It also evaluated whether virtual reality training helped surgeons acquire equivalent (or better) technical skills required to achieve good surgical outcomes, or the non-technical skills to make good decisions and lead the operating room team. Another consideration evaluated was the level of experience of participants in the trials, given that some of the study participants were surgeons in training, while others were medical students.  
cochrane.org
almost 5 years ago
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Left multiloculated empyema in lungs CT chest

Prepare for USMLE,UK,CANADIAN,AUSTRALIAN, NURSING & OTHER MEDICAL BOARD examinations around the globe with us.Understand the basics, concepts and how to answ...  
youtube.com
almost 5 years ago