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Rheumatology

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Ehlers-Danlos Syndrome (EDS)

Ehlers-Danlos syndrome is an inherited connective tissue disorder caused by defective collagen synthesis. Symptoms vary widely between individuals. Some may be hardly effected, whilst other live severely restricted lives.   Epidemiology and Aetiology    
almostadoctor.com - free medical student revision notes
over 5 years ago
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3
68

Fibromyalgia

Fibromyalgia is a non-specific muscular disorder of unknown origin. It primarily affects insertions of tendons and associated soft tissues and presents with dull aching pains. It is much more common in women.  Epidemiology and Aetiology Cause is unknown Affects muscles rather than joints – although can often feel like joint pain Peak age of onset: 40-50 years M:F ratio 1:9  Pathology  
almostadoctor.com - free medical student revision notes
over 5 years ago
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4
55

Basic Physiology of Metabolism

Only 1% of pancreatic tissue is endocrine. This tissue is found in the Islets of langerhans. Surrounding the islets are adipose tissue deposits. The older you get, the more adipose tissue you have. There are four types of cell in the islets of langerhans, alpha, beta, delta and F. Alpha and beta secreted substances involved with control of glucose, delta and F cells control the level of action of the gastrointestinal tract.     
almostadoctor.com - free medical student revision notes
over 5 years ago
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1
18

Osgood-Schlatter disease

This is a painful condition in which there is injury to the tibial tuberosity where it joins with the patellar tendon. It is commonly found in adolescents who participate in a lot of sporting activities during their growth spurt. The patellar tendon causes damage to the tibial tuberosity due to a combination of increased quadriceps muscle strength, immaturity of the bone and repeated strain. Inflammation and increased bone growth around the tuberosity sometimes creates a palpable bony nodule just below the patellar tendon that may be painful.    
almostadoctor.com - free medical student revision notes
over 5 years ago
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8
258

Physiology of Lipoprotein Metabolism

Reducing the Atherogenic Burden Molecular Disease Branch National Heart, Lung and Blood Institute National Institutes of Health Bethesda, Maryland  
YouTube
over 5 years ago
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1
18

Recognising and treating fibromyalgia

Stream Recognising and treating fibromyalgia by BMJ talk medicine from desktop or your mobile device  
SoundCloud
over 5 years ago
Www.bmj
1
18

A patient with rheumatoid arthritis, cryoglobulinaemia, and an “accidental” finding

A 60 year old woman, originally from Greece, was admitted after burning herself while trying to warm her legs on an electric heater. She had rheumatoid arthritis treated with methotrexate and adalimumab.  
bmj.com
over 5 years ago
Www.bmj
1
13

What is an “n-of-1” trial?

Researchers assessed the effectiveness of “n-of-1” trials for the short term choice of drugs for osteoarthritis. The efficacy of sustained release paracetamol was compared with celecoxib in the management of symptoms associated with osteoarthritis. A series of double blind randomised n-of-1 controlled trials using a double dummy design was performed. The intervention was sustained release paracetamol (two 665 mg tablets, three times a day), or celecoxib (200 mg daily, or 200 mg twice a day for those who were already using this dose). Each treatment regimen was taken for two weeks, administered for three treatment cycles. The primary outcome measures included pain, stiffness, and functional limitation scores; preferred treatment; and adverse effects.1  
bmj.com
over 5 years ago
Www.bmj
2
44

A patient with rheumatoid arthritis, cryoglobulinaemia, and an “accidental” finding

A 60 year old woman, originally from Greece, was admitted after burning herself while trying to warm her legs on an electric heater. She had rheumatoid arthritis treated with methotrexate and adalimumab.  
bmj.com
over 5 years ago
Www.bmj
1
18

A patient with rheumatoid arthritis, cryoglobulinaemia, and an “accidental” finding

A 60 year old woman, originally from Greece, was admitted after burning herself while trying to warm her legs on an electric heater. She had rheumatoid arthritis treated with methotrexate and adalimumab.  
bmj.com
over 5 years ago
Www.bmj
1
17

A patient with rheumatoid arthritis, cryoglobulinaemia, and an “accidental” finding

A 60 year old woman, originally from Greece, was admitted after burning herself while trying to warm her legs on an electric heater. She had rheumatoid arthritis treated with methotrexate and adalimumab.  
bmj.com
over 5 years ago
Www.bmj
1
15

A patient with rheumatoid arthritis, cryoglobulinaemia, and an “accidental” finding

A 60 year old woman, originally from Greece, was admitted after burning herself while trying to warm her legs on an electric heater. She had rheumatoid arthritis treated with methotrexate and adalimumab.  
bmj.com
over 5 years ago
Www.bmj
1
12

What is an “n-of-1” trial?

Researchers assessed the effectiveness of “n-of-1” trials for the short term choice of drugs for osteoarthritis. The efficacy of sustained release paracetamol was compared with celecoxib in the management of symptoms associated with osteoarthritis. A series of double blind randomised n-of-1 controlled trials using a double dummy design was performed. The intervention was sustained release paracetamol (two 665 mg tablets, three times a day), or celecoxib (200 mg daily, or 200 mg twice a day for those who were already using this dose). Each treatment regimen was taken for two weeks, administered for three treatment cycles. The primary outcome measures included pain, stiffness, and functional limitation scores; preferred treatment; and adverse effects.1  
bmj.com
over 5 years ago
Www.bmj
1
21

A patient with rheumatoid arthritis, cryoglobulinaemia, and an “accidental” finding

A 60 year old woman, originally from Greece, was admitted after burning herself while trying to warm her legs on an electric heater. She had rheumatoid arthritis treated with methotrexate and adalimumab.  
bmj.com
over 5 years ago
Www.bmj
1
15

What is an “n-of-1” trial?

Researchers assessed the effectiveness of “n-of-1” trials for the short term choice of drugs for osteoarthritis. The efficacy of sustained release paracetamol was compared with celecoxib in the management of symptoms associated with osteoarthritis. A series of double blind randomised n-of-1 controlled trials using a double dummy design was performed. The intervention was sustained release paracetamol (two 665 mg tablets, three times a day), or celecoxib (200 mg daily, or 200 mg twice a day for those who were already using this dose). Each treatment regimen was taken for two weeks, administered for three treatment cycles. The primary outcome measures included pain, stiffness, and functional limitation scores; preferred treatment; and adverse effects.1  
www.bmj.com
over 5 years ago
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1
18

Inactivity, disability, and death are all interlinked

Physical activity has long been recognised as an important determinant of health and longevity, and many countries have explicit physical activity guidelines for promoting health.1 2 The corollary of this is that people who do not meet the guidelines, a substantial proportion of the population,3 are at risk of worse health. However, relatively little attention has been given to the question of how much activity is needed to make a difference. Although this is not explicitly their primary purpose, two new papers shed light on this question. Dunlop and colleagues (doi:10.1136/bmj.g2472) followed a cohort of people who had mild to moderate osteoarthritis or were at risk of osteoarthritis to look at the development of disability over two years.4 Cooper and colleagues (doi:10.1136/bmj.g2219) estimated the relation between physical capability in midlife—as indicated by grip strength, chair rise speed, and standing balance—and later mortality.5 Both showed that the relation between inactivity and risk of disability or death is not linear: people …  
bmj.com
over 5 years ago
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1
20

Relation of physical activity time to incident disability in community dwelling adults with or at risk of knee arthritis: prospective cohort study

Objective To investigate whether objectively measured time spent in light intensity physical activity is related to incident disability and to disability progression.  
bmj.com
over 5 years ago
Preview
3
53

Inactivity, disability, and death are all interlinked

Physical activity has long been recognised as an important determinant of health and longevity, and many countries have explicit physical activity guidelines for promoting health.1 2 The corollary of this is that people who do not meet the guidelines, a substantial proportion of the population,3 are at risk of worse health. However, relatively little attention has been given to the question of how much activity is needed to make a difference. Although this is not explicitly their primary purpose, two new papers shed light on this question. Dunlop and colleagues (doi:10.1136/bmj.g2472) followed a cohort of people who had mild to moderate osteoarthritis or were at risk of osteoarthritis to look at the development of disability over two years.4 Cooper and colleagues (doi:10.1136/bmj.g2219) estimated the relation between physical capability in midlife—as indicated by grip strength, chair rise speed, and standing balance—and later mortality.5 Both showed that the relation between inactivity and risk of disability or death is not linear: people …  
bmj.com
over 5 years ago
Preview
1
30

Relation of physical activity time to incident disability in community dwelling adults with or at risk of knee arthritis: prospective cohort study

Objective To investigate whether objectively measured time spent in light intensity physical activity is related to incident disability and to disability progression.  
bmj.com
over 5 years ago
Preview
1
4

Reactive Arthritis

 
almostadoctor.com - free medical student revision notes
over 5 years ago