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Sinaiem dark
0
3

status-epilepticus-2

Your patient arrives by ambulance having a seizure.  EMS administered ativan 10 minutes ago.  You give a second dose but the seizure continues.  What should you do?  
sinaiem.org
over 5 years ago
Preview
0
3

Carbamazepine versus phenytoin monotherapy (single drug treatment) for epilepsy | Cochrane

Epilepsy is a common neurological disorder in which recurrent seizures are caused by abnormal electrical discharges from the brain. We studied two types of epileptic seizures in this review; generalised onset seizures in which electrical discharges begin in one part of the brain and move throughout the brain, and partial onset seizures in which the seizure is generated in, and affects one part of the brain (the whole hemisphere of the brain or part of a lobe of the brain). For around 70% of people with epilepsy, generalised onset or partial onset seizures can be controlled by a single antiepileptic drug. Worldwide, phenytoin and carbamazepine are commonly used antiepileptic drugs, however carbamazepine is used more commonly in the USA and Europe due to concerns over side effects associated with phenytoin. Phenytoin is still commonly used in developing countries in Africa, Asia and South America due to the low cost of the drug.  
cochrane.org
over 5 years ago
Preview
0
7

Medicines for preventing epilepsy following traumatic head injury | Cochrane

Traumatic head injury is a frequent event and can injure the brain. This severe injury is often followed by seizures (fits), which may worsen the damage and can lead to chronic epilepsy, a neurologic disorder characterized by frequent recurrent seizures. Antiepileptic drugs are usually given to suppress already diagnosed seizures. Their role in curing the disease and preventing the development of epilepsy in people who are considered at risk for seizures after any brain injury, including head trauma, is not well understood.  
cochrane.org
over 5 years ago
Preview
0
15

FDA approves first 3-D printed drug

WASHINGTON — The Food and Drug Administration has approved the first prescription drug made through 3-D printing: a dissolvable tablet that treats seizures. Aprecia Pharmaceuticals said Monday the FDA approved its drug Spritam for adults and children who suffer from certain types of seizures caused by epilepsy. The tablet is manufactured through a layered process via 3-D printing and dissolves when taken with liquid. The Ohio-based company says its printing system can package potent drug doses of up to 1,000 milligrams into individual tablets. It expects to launch Spritam in the first quarter of 2016. The FDA has previously approved medical devices — including prosthetics — made with 3-D printing. An agency spokeswoman confirmed the new drug is the first prescription tablet approved that uses the process. Aprecia said in a statement it plans to develop other medications using its 3-D platform in coming years, including more neurological drugs. The company is privately owned. Doctors are increasingly turning to 3-D printing to create customized implants for patients with rare conditions and injuries, including children who cannot be treated with adult-size devices. The FDA held a workshop last year for medical manufacturers interested in the technology.  
nypost.com
over 5 years ago
Www.bmj
0
18

A pain in the neck type of headache

A 29 year old right hand dominant chef presented to the emergency department with a four day history of feeling “not normal.” He was sent home from work because of a gradual onset of dull pain on the left side of his neck radiating up into his head, which was getting progressively worse, as well as “seeing two of everything.” The pain was not influenced by changes in posture. In addition, his right side felt numb and he was dropping things at work. He felt unsteady on his feet, which prompted him to seek medical advice. He thought all his symptoms had come on suddenly and were gradually getting worse. He denied any recent alcohol consumption, illicit drug use, seizure activity, head injury, or loss of consciousness. He had no medical history of note, apart from hypothyroidism, for which he was taking thyroxine.  
feeds.bmj.com
over 5 years ago
Preview
0
12

Carbamazepine versus phenobarbitone monotherapy (single drug treatment) for epilepsy | Cochrane

Epilepsy is a common neurological disorder in which abnormal electrical discharges from the brain cause recurrent seizures. We studied two types of epileptic seizures in this review: generalised onset seizures in which electrical discharges begin in one part of the brain and move throughout the brain, and partial onset seizures in which the seizure is generated in and affects one part of the brain (the whole hemisphere of the brain or part of a lobe of the brain). For around 70% of people with epilepsy, a single antiepileptic drug can control generalised onset or partial onset seizures. Worldwide, phenobarbitone (PB) and carbamazepine (CBZ) are commonly used antiepileptic drugs; however, CBZ is used more commonly in the USA and Europe because of concerns over side-effects associated with PB, particularly concerns over behavioural changes in children treated with PB. Phenobarbitone is still commonly used in developing countries in Africa, Asia, and South America because of the low cost of the drug.  
cochrane.org
over 5 years ago
Preview
1
21

Propofol versus thiopental sodium for the treatment of refractory status epilepticus (RSE) | Cochrane

Persistent convulsions (lasting 30 minutes or more) are a major medical emergency associated with significant morbidity and mortality. At times, these convulsions fail to respond to first- and second-line drug therapy and may occur in up to 31% of patients suffering from persistent seizure or convulsive activities. Persistent seizure activity may become unresponsive to antiepileptic drugs. Anaesthetics such as thiopental sodium and propofol are frequently given for control of seizures in such situations. Both agents have their own side effects and complications. This review evaluates the evidence for the use of these anaesthetic drugs in controlling seizure activity in patients with RSE.  
cochrane.org
over 5 years ago
Preview
0
12

Are there any differences in survival between people with low grade glioma having early compared with delayed radiotherapy at the time of progression? | Cochrane

The issue Low grade gliomas are brain tumours that predominantly affect young adults. They grow at slower rates and are typically associated with a favourable prognosis compared with high grade gliomas. One of the most common presenting symptoms of people with LGG are seizures. Although, there are no definitive guidelines on the management of LGGs, most people with LGGs are treated with a combination of surgery followed by radiotherapy. However, it is unclear whether to use radiotherapy in the early postoperative period, or to delay until the disease progresses.  
cochrane.org
over 5 years ago