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Carbamazepine versus phenytoin monotherapy (single drug treatment) for epilepsy | Cochrane

Epilepsy is a common neurological disorder in which recurrent seizures are caused by abnormal electrical discharges from the brain. We studied two types of epileptic seizures in this review; generalised onset seizures in which electrical discharges begin in one part of the brain and move throughout the brain, and partial onset seizures in which the seizure is generated in, and affects one part of the brain (the whole hemisphere of the brain or part of a lobe of the brain). For around 70% of people with epilepsy, generalised onset or partial onset seizures can be controlled by a single antiepileptic drug. Worldwide, phenytoin and carbamazepine are commonly used antiepileptic drugs, however carbamazepine is used more commonly in the USA and Europe due to concerns over side effects associated with phenytoin. Phenytoin is still commonly used in developing countries in Africa, Asia and South America due to the low cost of the drug.  
cochrane.org
over 5 years ago
Sinaiem dark
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status-epilepticus-2

Your patient arrives by ambulance having a seizure.  EMS administered ativan 10 minutes ago.  You give a second dose but the seizure continues.  What should you do?  
sinaiem.org
over 5 years ago
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FDA Revokes Approval for Sun Pharma's Seizure Drug Over Compliance Issues

The U.S. Food and Drug Administration has revoked an approval issued in March to India's Sun Pharma Advanced Research Company Ltd (SPARC) to launch a drug for seizures, citing manufacturing quality problems at its production site.  
medscape.com
over 5 years ago