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Carbamazepine versus phenytoin monotherapy (single drug treatment) for epilepsy | Cochrane

Epilepsy is a common neurological disorder in which recurrent seizures are caused by abnormal electrical discharges from the brain. We studied two types of epileptic seizures in this review; generalised onset seizures in which electrical discharges begin in one part of the brain and move throughout the brain, and partial onset seizures in which the seizure is generated in, and affects one part of the brain (the whole hemisphere of the brain or part of a lobe of the brain). For around 70% of people with epilepsy, generalised onset or partial onset seizures can be controlled by a single antiepileptic drug. Worldwide, phenytoin and carbamazepine are commonly used antiepileptic drugs, however carbamazepine is used more commonly in the USA and Europe due to concerns over side effects associated with phenytoin. Phenytoin is still commonly used in developing countries in Africa, Asia and South America due to the low cost of the drug.  
cochrane.org
over 4 years ago
Sinaiem dark
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status-epilepticus-2

Your patient arrives by ambulance having a seizure.  EMS administered ativan 10 minutes ago.  You give a second dose but the seizure continues.  What should you do?  
sinaiem.org
over 4 years ago
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Respiratory tract infection associated with seizures

A two year old girl presented to her local hospital with breathing difficulties. She was diagnosed with virus induced wheeze. On day one of admission she deteriorated and developed respiratory failure, which required ventilatory support and transfer to our paediatric intensive care unit. Figure 1⇓ shows her chest radiograph on arrival. A multiplex polymerase chain reaction (PCR) panel performed on respiratory secretions identified a micro-organism. She was successfully extubated to nasal cannula oxygen two days later and transferred to a paediatric ward. Four hours after transfer she had a prolonged tonic-clonic convulsion. Owing to profound respiratory depression after two doses of lorazepam she required re-intubation and transfer back to the paediatric intensive care unit.  
feeds.bmj.com
over 4 years ago
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Respiratory tract infection associated with seizures

A two year old girl presented to her local hospital with breathing difficulties. She was diagnosed with virus induced wheeze. On day one of admission she deteriorated and developed respiratory failure, which required ventilatory support and transfer to our paediatric intensive care unit. Figure 1⇓ shows her chest radiograph on arrival. A multiplex polymerase chain reaction (PCR) panel performed on respiratory secretions identified a micro-organism. She was successfully extubated to nasal cannula oxygen two days later and transferred to a paediatric ward. Four hours after transfer she had a prolonged tonic-clonic convulsion. Owing to profound respiratory depression after two doses of lorazepam she required re-intubation and transfer back to the paediatric intensive care unit.  
feeds.bmj.com
over 4 years ago
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Non-pharmacological interventions for people with epilepsy and intellectual disabilities | Cochrane

Epilepsy is a neurological condition characterised by involuntary activity of the brain, which manifests in seizures. The rate of epilepsy in people with intellectual diabilities is significantly higher than in the general population. Epilepsy in this population is often less responsive to antiepileptic drugs (AEDs) and is associated with higher rates of morbidity and mortality. One relevant study comparing two surgical procedures has been included in this review. This study found that anterior corpus callosotomy (a procedure in which a section of the corpus callosum is severed) with anterior temporal lobectomy (a procedure in which part of the temporal lobe is removed) is more effective than anterior temporal lobectomy alone in improving quality of life and performance on IQ tests among people with epilepsy and intellectual disabilities. No support was found for a relative benefit of either procedure for improved seizure control. This review accentuates the lack of randomised controlled trials (RCTs) evaluating non-pharmacological interventions for people with epilepsy and intellectual disabilities. Given the prevalence and nature of epilepsy in this population, well-designed RCTs are needed to ascertain the effects of non-pharmacological interventions on seizure and behavioural outcomes in people with intellectual disabilities. However, good quality evidence derived from RCTs including the non-intellectually disabled should be assessed for side effects and efficacy before such studies are undertaken.  
cochrane.org
over 4 years ago
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Modified Atkins Diet Limits Seizures in Refractory Epilepsy

A ketogenic diet, a modified version of the Atkins diet, has been used to help control epilepsy in children. It now has shown efficacy in adults with drug-refractory disease, a study shows.  
medscape.com
over 4 years ago
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What Meds Could Help Prevent a Recurrent Eclamptic Seizure in a Pregnant Woman?

A 20-year-old G1 at 36 weeks is being monitored for preeclampsia. What medication is recommended for the prevention of a recurrent eclamptic seizure?  
medscape.com
over 4 years ago
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Heart Rate-Triggered Vagus Stimulator Offers Seizure Control

A vagus nerve stimulator triggered by the increase in heart rate before a seizure offers patients with drug-refractory epilepsy better seizure control and improved quality of life, a study shows.  
medscape.com
over 4 years ago
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Patient-centered Approaches to Managing Seizure Clusters CME/CE

This activity is intended for neurologists, primary care providers, emergency medicine physicians, nurses, pharmacists, and other clinicians involved in the management of seizure clusters  
medscape.org
over 4 years ago
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Focal Seizure on the right hand

Prepare for USMLE,UK,CANADIAN,AUSTRALIAN, NURSING & OTHER MEDICAL BOARD examinations around the globe with us.Understand the basics, concepts and how to answ...  
youtube.com
over 4 years ago
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The Art and Science of Diagnosing Seizures CME

The goal of this activity is to improve physicians’ competency and confidence in diagnosing patients with epileptic seizures.  
medscape.org
over 4 years ago
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Switching AED Forms Improves Seizure Control for ID Patients

Seizure control improved by 50% when patients with epilepsy and intellectual disability were switched from a liquid to a granule form of levetiracetam, a study shows. Gut absorption may be the reason.  
medscape.com
over 4 years ago
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Recognizing and managing paradoxical reactions from benzodiazepines & propofol

. A perplexing case . A young man with a history of seizures and alcoholism presented with a generalized seizure.  His seizure responded to lorazepam, but  
pulmcrit.org
over 4 years ago
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FDA Revokes Approval for Sun Pharma's Seizure Drug Over Compliance Issues

The U.S. Food and Drug Administration has revoked an approval issued in March to India's Sun Pharma Advanced Research Company Ltd (SPARC) to launch a drug for seizures, citing manufacturing quality problems at its production site.  
medscape.com
over 4 years ago
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Respiratory tract infection associated with seizures

A two year old girl presented to her local hospital with breathing difficulties. She was diagnosed with virus induced wheeze. On day one of admission she deteriorated and developed respiratory failure, which required ventilatory support and transfer to our paediatric intensive care unit. Figure 1⇓ shows her chest radiograph on arrival. A multiplex polymerase chain reaction (PCR) panel performed on respiratory secretions identified a micro-organism. She was successfully extubated to nasal cannula oxygen two days later and transferred to a paediatric ward. Four hours after transfer she had a prolonged tonic-clonic convulsion. Owing to profound respiratory depression after two doses of lorazepam she required re-intubation and transfer back to the paediatric intensive care unit.  
feeds.bmj.com
over 4 years ago
Preview
0
0

Respiratory tract infection associated with seizures

A two year old girl presented to her local hospital with breathing difficulties. She was diagnosed with virus induced wheeze. On day one of admission she deteriorated and developed respiratory failure, which required ventilatory support and transfer to our paediatric intensive care unit. Figure 1⇓ shows her chest radiograph on arrival. A multiplex polymerase chain reaction (PCR) panel performed on respiratory secretions identified a micro-organism. She was successfully extubated to nasal cannula oxygen two days later and transferred to a paediatric ward. Four hours after transfer she had a prolonged tonic-clonic convulsion. Owing to profound respiratory depression after two doses of lorazepam she required re-intubation and transfer back to the paediatric intensive care unit.  
feeds.bmj.com
over 4 years ago
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Can Headaches During Pregnancy Trigger Red Flags? CME/CE

: Approximately one-third of pregnant women receiving neurologic consultation for headache have secondary causes, particularly those without headache history and with seizures, hypertension, or fever.  
medscape.org
over 4 years ago
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Respiratory tract infection associated with seizures

A two year old girl presented to her local hospital with breathing difficulties. She was diagnosed with virus induced wheeze. On day one of admission she deteriorated and developed respiratory failure, which required ventilatory support and transfer to our paediatric intensive care unit. Figure 1⇓ shows her chest radiograph on arrival. A multiplex polymerase chain reaction (PCR) panel performed on respiratory secretions identified a micro-organism. She was successfully extubated to nasal cannula oxygen two days later and transferred to a paediatric ward. Four hours after transfer she had a prolonged tonic-clonic convulsion. Owing to profound respiratory depression after two doses of lorazepam she required re-intubation and transfer back to the paediatric intensive care unit.  
feeds.bmj.com
over 4 years ago
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Mindfulness-Based Therapy Promising for Resistant Epilepsy

A new study shows that adding a form of mental meditation to the care of those with resistant epilepsy improved quality of life, seizure frequency, and other measures.  
medscape.com
over 4 years ago
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Lab Case 74 – Interpretation

Causes of acid base disorder – Renal failure, Addison’s disease/ crisis ppt by acute gastric illness, consider other causes. Has patient had a seizure (ICH/ meningitis/ low Na)?  
emergucate.com
over 4 years ago