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Critical Care

Acute-phase proteins, such as procalcitonin (PCT), C-reactive protein (CRP) and albumin, may relate with course and outcome in status epilepticus (SE), as seizures bring about inflammation, changes of cytokine levels and blood–brain barrier breakdown. We aimed to determine the predictive value of serum levels of PCT at SE onset for the emergence of infections and unfavorable outcome in adult patients with SE. Furthermore, we sought to compare the predictive value of PCT, CRP and albumin for death.  
ccforum.com
almost 5 years ago
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Treatment of epilepsy in people with neurocysticercosis | Cochrane

Neurocysticercosis is a common infection of the brain caused by the larvae of the pork tapeworm, migrating to the brain. Seizure is the most common symptom, while some people may present with headache, vomiting or brain swelling. This review investigates the usefulness of antiepileptic drugs (AEDs) in preventing seizures in people who did not have seizures but presented with headache or brain oedema. We also examined the usefulness of the AEDS in people with neurocysticercosis with epilepsy in terms of choice of drug, dosage, duration of treatment, cost, side effects and the quality of life.  
cochrane.org
almost 5 years ago
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Epilepsy App Tracks Seizures

Information gathered with the new interactive app, downloaded to the Apple Watch, will be used to develop a seizure detector.  
medscape.com
almost 5 years ago
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Antiepileptic drugs for the treatment of infants with severe myoclonic epilepsy | Cochrane

Severe myoclonic epilepsy in infants (SMEI), also known as Dravet syndrome, is a rare, drug-resistant form of epilepsy, for which stiripentol (STP) has been recently licensed for treatment when given in combination with other antiepileptic drugs. In this review, we evaluated the efficacy and tolerability of STP and other antiepileptic drugs for the treatment of SMEI. Upon systematically searching (27 April 2015) the medical literature, we found no randomised controlled trials (RCTs) assessing drugs other than STP. We found two RCTs evaluating the efficacy and tolerability of STP in 64 children with SMEI compared with placebo. Compared with patients given placebo, those receiving STP were more likely to be seizure free or to have 50% or greater reduction in seizure frequency. Only one study explicitly reported the occurrence of side effects, which occurred more frequently in patients treated with STP. These data, derived from two small studies, indicate that STP is significantly better than placebo with regards to efficacy but is not as well tolerated. Further studies should be conducted to unequivocally establish the long-term efficacy and tolerability of STP in the treatment of patients with SMEI.  
cochrane.org
almost 5 years ago
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Stiripentol for focal refractory epilepsy | Cochrane

Epilepsy is one of the more common chronic neurological disorders; it affects 1% of the population worldwide. A large proportion of these people (up to 30%) continue to have seizures despite adequate therapy with antiepileptic drugs (AEDs), used singularly (as monotherapy) or in combination (polytherapy). These individuals are regarded as having refractory epilepsy. Stiripentol is a new AED that was developed in France and was approved in 2007 by the European Medicines Agency (EMA) for the treatment of Dravet syndrome as adjunctive therapy with valproate and clobazam, with promising effects. This review appraised evidence for the use of stiripentol as add-on treatment for focal refractory epilepsy in individuals taking AEDs.  
cochrane.org
almost 5 years ago
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Sudoku and Seizures?

Researchers report a case of clonic seizures induced by solving Sudoku puzzles.  
medscape.com
almost 5 years ago
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CDC Warning: Fentanyl-Related Fatalities Rising

The CDC has released an alert related to a recent significant spike in fentanyl drug seizures by law enforcement and possible related fatalities.  
medscape.com
almost 5 years ago
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Lab Case 77 – Interpretation

Causes of seizure are numerous but in this patient drug abuse is a major cause. It turns out the patient was taking 400-600mg of tramadol per day and had been doctor shopping for tramadol.  
emergucate.com
almost 5 years ago
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Sulthiame add-on therapy for epilepsy | Cochrane

Epilepsy is a common neurological (brain) condition that is characterised by recurrent seizures (fits). Most patients respond well to conventional antiepileptic medicines, although about 30% of patients (non responders) will continue to have seizures .  
cochrane.org
almost 5 years ago
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Smoking and Seizures: Where the Evidence Stands

Dr Wilner describes the epidemiology of smoking among people with epilepsy, the potential effects of nicotine on seizures, and seizure risks among smoking cessation medications.  
medscape.com
almost 5 years ago
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CHMP Recommends EU Approval for Brivaracetam

The Committee for Medicinal Products for Human Use recommends marketing approval for brivaracetam (Briviact, UCB Pharma SA) as adjunctive therapy for partial-onset seizures.  
medscape.com
over 4 years ago
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Seizures in Children and Adolescents Aged 6-17 Years

This report assessed the incidence and causes of seizures in children and adolescents, as well as sociodemographic characteristics of children with seizures as compared to the general population.  
medscape.com
over 4 years ago
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Synconvulsions: Just how common are convulsions in syncope? (Re-post)

This post originally appeared on PEMBlog back in August of 2014 and has been reposted because I think it is a really important topic.  
pemcincinnati.com
over 4 years ago
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Atypical Symptoms After Ibogaine Intoxication

Was this patient's grand-mal seizure caused by his use of ibogaine, an herbal psychoactive drug which is used recreationally as well as experimentally to treat drug withdrawal symptoms?  
medscape.com
over 4 years ago
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Autoimmune Epilepsy Gaining Attention

Researchers are learning more about antibodies that attack the brain, causing various seizure syndromes.  
medscape.com
over 4 years ago
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Hyponatremic Seizure

This case is written by Dr. Kyla Caners. She is a PGY5 Emergency Medicine resident at McMaster University and is also one of the Editors-in-Chief here at EMSimCases. Why it Matters This case allows educators to review the approach to a common condition while also pushing learners to think outside conventional treatments. In particular, it…  
emsimcases.com
over 4 years ago
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Wearable Seizure Detection Devices Promising

New portable devices that monitor for seizures are lighter, smaller, and better than before, researchers say.  
medscape.com
over 4 years ago
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Biofeedback Reduces Seizures in Intractable Epilepsy

Electrodermal biofeedback is a promising approach to reducing seizure frequency in drug-resistant epilepsies.  
medscape.com
over 4 years ago