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SensitivityAndSpecificity

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Atopic Dermatitis

Atopic dermatitis is a skin inflammation caused by sensitivity to something in the environment. It often runs in families and may occur along with hay fever,...  
youtube.com
almost 4 years ago
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Head Turning Sign May Help Identify Alzheimer's

A new study of patients with dementia showed high sensitivity and predictive value of the test that helps distinguish Alzheimer's from other conditions.  
medscape.com
almost 4 years ago
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R.E.B.E.L. EM - Xanthochromia Detection: Visual Inspection vs. Spectrophotometry - emdocs

An LP gives providers the ability to perform CSF analysis for red blood cells and detect xanthochromia by visual inspection or spectrophotometry. In most of the world, including the United States, the predominant approach to identifying xanthochromia is visual detection. However, this technique is subjective and considered unreliable by many. Spectrophotometry is a more objective test but, has lower specificity, carries a higher cost and is unavailable in the majority of hospitals.  
emdocs.net
about 4 years ago
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Position-Related Neurapraxia Prediction Not Always on Target

Intraoperative monitoring for neurapraxia shown to have low sensitivity in predicting nerve deficit.  
medscape.com
about 4 years ago
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Introduction to Psychology 1.0 | Flat World Education

The most fundamental emotions, known as the basic emotionsThe emotions of anger, disgust, fear, happiness, sadness, and surprise., are those of anger, disgust, fear, happiness, sadness, and surprise. The basic emotions have a long history in human evolution, and they have developed in large part to help us make rapid judgments about stimuli and to quickly guide appropriate behavior (LeDoux, 2000).LeDoux, J. E. (2000). Emotion circuits in the brain. Annual Review of Neuroscience, 23, 155–184. The basic emotions are determined in large part by one of the oldest parts of our brain, the limbic system, including the amygdala, the hypothalamus, and the thalamus. Because they are primarily evolutionarily determined, the basic emotions are experienced and displayed in much the same way across cultures (Ekman, 1992; Elfenbein & Ambady, 2002, 2003; Fridland, Ekman, & Oster, 1987),Ekman, P. (1992). Are there basic emotions? Psychological Review, 99(3), 550–553; Elfenbein, H. A., & Ambady, N. (2002). On the universality and cultural specificity of emotion recognition: A meta-analysis. Psychological Bulletin, 128, 203–23; Fridlund, A. J., Ekman, P., & Oster, H. (1987). Facial expressions of emotion. In A. Siegman & S. Feldstein (Eds.), Nonverbal behavior and communication (2nd ed., pp. 143–223). Hillsdale, NJ: Lawrence Erlbaum Associates. and people are quite accurate at judging the facial expressions of people from different cultures. View "Video Clip: The Basic Emotions" to see a demonstration of the basic emotions.  
catalog.flatworldknowledge.com
about 4 years ago
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180

Sensitivity and Specificity

Easily understand the concepts of SENSITIVITY and SPECIFICITY! These two words can be confusing when you are first learning the basics of biostatistics.  
youtu.be
about 4 years ago
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Neonatal Circumcision Does Not Reduce Sensitivity in Men

Circumcised and uncircumcised men did not differ in penile sensitivity, and the foreskin was not the most sensitive part of the penis, a new study showed.  
medscape.com
about 4 years ago
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UMEM Educational Pearls - University of Maryland School of Medicine, Department of Emergency Medicine

Typically, if an infant or young child presents to the ED with concern for intracranial hemorrhage (ICH), CT is performed as a rapid diagnostic tool. Now that clinicians are more aware of the radiation associated with head CT, the possible use of ultrasound was studied. Ultrasound is commonly used in the neonatal population for detecting ICH. A study by Elkhunovich et al looked at children younger than 2 years who had cranial ultrasounds preformed. Over a 5 year period, 283 ultrasounds were done on patients between 0 to 485 days old (median 33 days). There were 39 bleeds detected. Ultrasound specificity and sensitivity was calculated by comparing the results with CT, MRI and/or clinical outcome. For significant bleeds, the sensitivity for ultrasound was 81%. The specificity for detecting ICH was 97%.  
umem.org
about 4 years ago
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High-Sensitivity Triage Strategy Pegged at $1.3 Million per QALY

Achieving current quality benchmarks for field trauma triage would not be cost-effective, new findings show.  
medscape.com
about 4 years ago
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Hope and Hype Push Liquid Biopsies in Oncology

Detecting cancer through tumor DNA circulating in the blood has both possibilities and limitations. Realizing its full potential depends in part on resolving cost and sensitivity issues.  
medscape.com
about 4 years ago
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Drug Sensitivity Testing for Gastric Cancer Diagnostics

Recent advances have made diagnostic drug sensitivity testing for cancer a reality. What methods are currently available for drug sensitivity testing in gastric cancer diagnostics?  
medscape.com
over 4 years ago
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CT Angiography for Suspected ACS in the Era of hs-Troponins

Does a diagnostic strategy supplemented by early coronary CT angiography offer an advantage over diagnosis via high-sensitivity troponin assay in suspected acute coronary syndrome?  
medscape.com
over 4 years ago
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A Clinical Decision Rule and CT for Subarachnoid Hemorrhage

A new study examines the sensitivity of early cranial CT and a clinical decision rule for detecting subarachnoid hemorrhage.  
medscape.com
over 4 years ago
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Xanthochromia Detection: Visual Inspection vs. Spectrophotometry - R.E.B.E.L. EM - Emergency Medicine Blog

Background: Although non-contrast head CT (NCHCT) has near perfect sensitivity (98-100%) in detecting aneurysmal subarachnoid hemorrhage (SAH) when performed within 6 hours of headache onset, sensitivity declines after 6 hours. As a result of declining sensitivity, lumbar puncture (LP) continues to be part of the workup in suspected SAH. An LP gives providers the ability to perform CSF analysis for red blood cells and detect xanthochromia by visual inspection or spectrophotometry. In most of the world, including the United States, the predominant approach to identifying xanthochromia is visual detection. However, this technique is subjective and considered unreliable by many. Spectrophotometry is a more objective test but, has lower specificity, carries a higher cost and is unavailable in the majority of hospitals.  
rebelem.com
over 4 years ago
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Net benefit approaches to the evaluation of prediction models, molecular markers, and diagnostic tests

Many decisions in medicine involve trade-offs, such as between diagnosing patients with disease versus unnecessary additional testing for those who are healthy. Net benefit is an increasingly reported decision analytic measure that puts benefits and harms on the same scale. This is achieved by specifying an exchange rate, a clinical judgment of the relative value of benefits (such as detecting a cancer) and harms (such as unnecessary biopsy) associated with models, markers, and tests. The exchange rate can be derived by asking simple questions, such as the maximum number of patients a doctor would recommend for biopsy to find one cancer. As the answers to these sorts of questions are subjective, it is possible to plot net benefit for a range of reasonable exchange rates in a “decision curve.” For clinical prediction models, the exchange rate is related to the probability threshold to determine whether a patient is classified as being positive or negative for a disease. Net benefit is useful for determining whether basing clinical decisions on a model, marker, or test would do more good than harm. This is in contrast to traditional measures such as sensitivity, specificity, or area under the curve, which are statistical abstractions not directly informative about clinical value. Recent years have seen an increase in practical applications of net benefit analysis to research data. This is a welcome development, since decision analytic techniques are of particular value when the purpose of a model, marker, or test is to help doctors make better clinical decisions.  
feeds.bmj.com
over 4 years ago
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Rapid Rule Out of AMI: Taking Cardiac Testing to the Next Level CME

The goal of this activity is to help clinicians understand recent clinical trial data on the use biomarkers, such as high-sensitivity cardiac troponin levels, to rapidly exclude acute myocardial infarction (AMI).  
medscape.org
over 4 years ago
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Discussion: a price for advances in medicine. Phase I clinical trial fail in France

Let me suggest a topic for discussion that might be a bit provocative. It's about the prices that sometimes we have to pay for advances in medicine. Ist phase clinical trial of a new painkiller drug manufactured by Bial (Portugal) failed with one man brain-dead and another five ones in critical state with neurologic symptoms, three of them are suspected to have irreversable changes in their CNS. [Links to news articles below] What is your opinion: who carries responsibility for these cases? Bial, Biotrial clinic that carried out the trial or maybe somone else involved? What kind of responsibility must it be provided the fact people involved in the study are volunteers and must have been consulted about specificity and all the issues that can arise in phase I clinical trials? Could there take place unproperly done preclinical trial? What do you think about it? ||You can follow these links to get more information about the case: http://www.bbc.com/news/world-europe-35337671 http://www.medscape.com/viewarticle/857379  
Alina Ivaniuk
over 4 years ago
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Sensitivity to Wheat, Gluten, and FODMAPs in IBS

Does science support a low FODMAP diet in patients with irritable bowel syndrome?  
medscape.com
over 4 years ago
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hs-Troponins Associated With Exercise-Induced Ischemia

High-sensitivity troponin levels pre- and post-stress testing can be a significant predictor of myocardial ischemia and "provide substantial incremental value to clinical judgement," say researchers.  
medscape.com
over 4 years ago