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7

Using haemoglobin A1c to diagnose type 2 diabetes or to identify people at high risk of diabetes

Haemoglobin A1c (HbA1c) can now be used as an alternative test to glucose concentration for diagnosing type 2 diabetes or identifying people at high risk of developing the disease  
bmj.com
over 5 years ago
Www.bmj
1
25

Treatment allocation in trials: cluster randomisation

Researchers investigated the effectiveness of neuromuscular training in reducing the rate of acute knee injuries in adolescent female football players. A cluster randomised controlled trial study design was used. The intervention was a 15 minute neuromuscular warm-up programme (targeting core stability, balance, and proper knee alignment) carried out twice a week throughout one season. A total of 230 football clubs were recruited from the female under 14 to under 18 series in eight regional districts of the Swedish Football Association, located in the middle and southern parts of Sweden. Clubs were randomised to the intervention or control using cluster allocation, stratified by regional district. In total, 121 clubs were allocated to the intervention group and 109 to the control group, and the clubs were followed for one season. The coaches of the clubs allocated to the control group were instructed to train and play as usual without any changes.1  
bmj.com
over 5 years ago
Www.bmj
1
29

Anticoagulation in atrial fibrillation

Atrial fibrillation increases the risk of stroke, which is a leading cause of death and disability worldwide. The use of oral anticoagulation in patients with atrial fibrillation at moderate or high risk of stroke, estimated by established criteria, improves outcomes. However, to ensure that the benefits exceed the risks of bleeding, appropriate patient selection is essential. Vitamin K antagonism has been the mainstay of treatment; however, newer drugs with novel mechanisms are also available. These novel oral anticoagulants (direct thrombin inhibitors and factor Xa inhibitors) obviate many of warfarin’s shortcomings, and they have demonstrated safety and efficacy in large randomized trials of patients with non-valvular atrial fibrillation. However, the management of patients taking warfarin or novel agents remains a clinical challenge. There are several important considerations when selecting anticoagulant therapy for patients with atrial fibrillation. This review will discuss the rationale for anticoagulation in patients with atrial fibrillation; risk stratification for treatment; available agents; the appropriate implementation of these agents; and additional, specific clinical considerations for treatment.  
bmj.com
over 5 years ago
Www.bmj
1
20

Anticoagulation in atrial fibrillation

Atrial fibrillation increases the risk of stroke, which is a leading cause of death and disability worldwide. The use of oral anticoagulation in patients with atrial fibrillation at moderate or high risk of stroke, estimated by established criteria, improves outcomes. However, to ensure that the benefits exceed the risks of bleeding, appropriate patient selection is essential. Vitamin K antagonism has been the mainstay of treatment; however, newer drugs with novel mechanisms are also available. These novel oral anticoagulants (direct thrombin inhibitors and factor Xa inhibitors) obviate many of warfarin’s shortcomings, and they have demonstrated safety and efficacy in large randomized trials of patients with non-valvular atrial fibrillation. However, the management of patients taking warfarin or novel agents remains a clinical challenge. There are several important considerations when selecting anticoagulant therapy for patients with atrial fibrillation. This review will discuss the rationale for anticoagulation in patients with atrial fibrillation; risk stratification for treatment; available agents; the appropriate implementation of these agents; and additional, specific clinical considerations for treatment.  
bmj.com
over 5 years ago
Www.bmj
1
12

Omega 3 supplements do not reduce cardiovascular risk in elderly

Commentators have said that more trials on the effects of omega 3 fatty acid supplements “seem unjustified” after another study found that their use was not associated with a reduced risk of cardiovascular disease. Patients should be advised to eat fish rather than take the supplements, they said.  
bmj.com
over 5 years ago
Www.bmj
1
11

Married women have lower risk of dying from heart disease than single women, says UK study

Women who are married or living with a partner have a similar risk of developing ischaemic heart disease to unmarried women but a substantially lower risk of dying from it, data from the Million Women cohort have shown.1  
bmj.com
over 5 years ago
Www.bmj
1
18

Anticoagulation in atrial fibrillation

Atrial fibrillation increases the risk of stroke, which is a leading cause of death and disability worldwide. The use of oral anticoagulation in patients with atrial fibrillation at moderate or high risk of stroke, estimated by established criteria, improves outcomes. However, to ensure that the benefits exceed the risks of bleeding, appropriate patient selection is essential. Vitamin K antagonism has been the mainstay of treatment; however, newer drugs with novel mechanisms are also available. These novel oral anticoagulants (direct thrombin inhibitors and factor Xa inhibitors) obviate many of warfarin’s shortcomings, and they have demonstrated safety and efficacy in large randomized trials of patients with non-valvular atrial fibrillation. However, the management of patients taking warfarin or novel agents remains a clinical challenge. There are several important considerations when selecting anticoagulant therapy for patients with atrial fibrillation. This review will discuss the rationale for anticoagulation in patients with atrial fibrillation; risk stratification for treatment; available agents; the appropriate implementation of these agents; and additional, specific clinical considerations for treatment.  
bmj.com
over 5 years ago
Www.bmj
1
30

Incretin based drugs and risk of acute pancreatitis in patients with type 2 diabetes: cohort study | The BMJ

Objectives To determine whether the use of incretin based drugs, compared with sulfonylureas, is associated with an increased risk of acute pancreatitis. - currently located behind a paywall. Your institution may have access through Athens/Elservier or similar.  
bmj.com
over 5 years ago
Www.bmj
1
29

Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies

Objective To investigate the risk of pancreatitis associated with the use of incretin-based treatments in patients with type 2 diabetes mellitus.  
bmj.com
over 5 years ago
Www.bmj
1
18

Higher sugar intake linked to raised risk of cardiovascular mortality, study finds

Higher consumption of added sugar is associated with an increased risk of cardiovascular mortality, a new US study has shown.1  
bmj.com
over 5 years ago
Www.bmj
1
54

Incretin based drugs and risk of acute pancreatitis in patients with type 2 diabetes: cohort study

Objectives To determine whether the use of incretin based drugs, compared with sulfonylureas, is associated with an increased risk of acute pancreatitis.  
bmj.com
over 5 years ago
Www.bmj
1
29

Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies

Objective To investigate the risk of pancreatitis associated with the use of incretin-based treatments in patients with type 2 diabetes mellitus.  
www.bmj.com
over 5 years ago
Www.bmj
1
18

Obesity, genetic risk, and environment

The alarming global rise in prevalence of obesity is caused by unhealthy obesogenic environments. In westernised societies we are all exposed to calorie dense food, sedentary lives, stress, and sleep deficit. Some people seem relatively insensitive to these environmental pressures, while others are severely affected and become obese.  
bmj.com
over 5 years ago
Www.bmj
1
10

Young women most at risk are least likely to be offered HPV vaccine

Young women most at risk of developing cervical cancer are the least likely to have been offered the human papillomavirus (HPV) vaccine or to have completed the course, according to a survey of women attending sexual health services in England.  
bmj.com
over 5 years ago
Www.bmj
1
30

Obesity, genetic risk, and environment

The alarming global rise in prevalence of obesity is caused by unhealthy obesogenic environments. In westernised societies we are all exposed to calorie dense food, sedentary lives, stress, and sleep deficit. Some people seem relatively insensitive to these environmental pressures, while others are severely affected and become obese.  
bmj.com
over 5 years ago
Www.bmj
1
4

I parodied a drug company’s direct-to-consumer advertising on YouTube

A Japanese company has been marketing an intravenous neuraminidase inhibitor direct to consumers through a television commercial and its website. But such use in low risk patients should not be encouraged, says Takashi Fujiwara, who decided to create his own YouTube infomercial  
bmj.com
over 5 years ago
Www.bmj
1
34

Using haemoglobin A1c to diagnose type 2 diabetes or to identify people at high risk of diabetes

Haemoglobin A1c (HbA1c) can now be used as an alternative test to glucose concentration for diagnosing type 2 diabetes or identifying people at high risk of developing the disease  
bmj.com
over 5 years ago
Www.bmj
3
132

Anticoagulation in atrial fibrillation

Atrial fibrillation increases the risk of stroke, which is a leading cause of death and disability worldwide. The use of oral anticoagulation in patients with atrial fibrillation at moderate or high risk of stroke, estimated by established criteria, improves outcomes. However, to ensure that the benefits exceed the risks of bleeding, appropriate patient selection is essential. Vitamin K antagonism has been the mainstay of treatment; however, newer drugs with novel mechanisms are also available. These novel oral anticoagulants (direct thrombin inhibitors and factor Xa inhibitors) obviate many of warfarin’s shortcomings, and they have demonstrated safety and efficacy in large randomized trials of patients with non-valvular atrial fibrillation. However, the management of patients taking warfarin or novel agents remains a clinical challenge. There are several important considerations when selecting anticoagulant therapy for patients with atrial fibrillation. This review will discuss the rationale for anticoagulation in patients with atrial fibrillation; risk stratification for treatment; available agents; the appropriate implementation of these agents; and additional, specific clinical considerations for treatment.  
bmj.com
over 5 years ago
Www.bmj
1
21

Management of women at high risk of breast cancer

The risk of breast cancer is multifactorial, but some women will have a high risk because of a genetic predisposition or, rarely, as a consequence of radiotherapy at a young age  
bmj.com
over 5 years ago
Www.bmj
1
15

Management of women at high risk of breast cancer

The risk of breast cancer is multifactorial, but some women will have a high risk because of a genetic predisposition or, rarely, as a consequence of radiotherapy at a young age  
feeds.bmj.com
over 5 years ago