StemCellTransplantation

Most patients with relapsing remitting multiple sclerosis (MS) who are taking part in a small study of high dose immunosuppressive therapy followed by transplantation of their own haematopoietic stem cells have experienced sustained remission for three years, a study has found.  

Most patients with relapsing remitting multiple sclerosis (MS) who are taking part in a small study of high dose immunosuppressive therapy followed by transplantation of their own haematopoietic stem cells have experienced sustained remission for three years, a study has found.  

Brentuximab vedotin proved effective in stopping disease progression in patients with hard-to-treat Hodgkin lymphoma when administered straight after stem cell transplantation.  

Abstract & Introduction: In adults with high-risk ALL treated with intensified pediatric-like protocol, allogeneic stem cell transplantation in first complete remission is associated with a 69.5% 3-year overall survival.  

Aiming to improve outcomes in autologous stem cell transplantation in myeloma, a Canadian trial investigates a novel agent for induction.  

We evaluated the evidence regarding whether giving platelet transfusions to patients with low platelets who are bleeding (therapeutically) is as effective and safe as giving platelet transfusions regularly to prevent bleeding (prophylactically). Our target population was people with blood cancers who were receiving intensive myelosuppressive (causing decreased blood cell production) chemotherapy treatments or stem cell transplantation.  

Abstract and Introduction: Matched donor hematopoietic stem cell transplantation has a good outcome in severe congenital neutropenia, but careful patient selection is needed because of high transplant-related mortality.  

We evaluated the evidence about whether low-dose platelet transfusions (platelet transfusions containing a lower number of platelets (1.1 x 1011/m2 ± 25%)) given to prevent bleeding in people with low platelet counts were as effective and safe as standard-dose (2.2 x 1011/m2 ± 25%) or high-dose platelet transfusions (platelet transfusions containing a larger number of platelets (4.4 x 1011/m2 ± 25%)) given regularly to prevent bleeding (prophylactically). Our target population was children and adults with blood cancers who were receiving intensive chemotherapy treatments or stem cell transplantation.  

We evaluated the evidence about whether platelet transfusions given to prevent bleeding in people with lower platelet counts (for example 5 x 109/L or below) were as effective and safe as the current standard (10 x 109/L or below), or whether higher platelet count levels (20 x 109/L or below, 30 x 109/L or below, or 50 x 109/L or below) were safer than the current standard (10 x 109/L or below). Our target population was people with blood cancers (for example leukaemia, lymphoma, myeloma) who were receiving intensive (myelosuppressive) chemotherapy treatments or stem cell transplantation.  

In recipients of nonrelated hematopoietic stem cell transplants, rabbit antithymocyte globulin (ATG) is associated with lower rates of chronic graft-vs-host disease. Should it be the standard of care?  

Aggressive immunosuppression followed by autologous haematopoietic stem cell transplantation (aHSCT) halted clinical relapses and the development of new brain lesions for a prolonged period in most patients with multiple sclerosis (MS) taking part in a small early stage trial, results published in the Lancet have shown.1  

Aggressive immunosuppression followed by autologous haematopoietic stem cell transplantation (aHSCT) halted clinical relapses and the development of new brain lesions for a prolonged period in most patients with multiple sclerosis (MS) taking part in a small early stage trial, results published in the Lancet have shown.1  

Aggressive immunosuppression followed by autologous haematopoietic stem cell transplantation (aHSCT) halted clinical relapses and the development of new brain lesions for a prolonged period in most patients with multiple sclerosis (MS) taking part in a small early stage trial, results published in the Lancet have shown.1  

Aggressive immunosuppression followed by autologous haematopoietic stem cell transplantation (aHSCT) halted clinical relapses and the development of new brain lesions for a prolonged period in most patients with multiple sclerosis (MS) taking part in a small early stage trial, results published in the Lancet have shown.1