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GI Bleeding in Patients With AF on Rivaroxaban or Warfarin

GI bleeding is a common complication of oral anticoagulation. How does the incidence of GI bleeding in AF patients taking rivaroxaban compare to those on warfarin?  
medscape.com
over 4 years ago
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New Blood Thinner 'Antidote' to Help Doctors Move Past Warfarin

A new class of blood thinners that competes with widely used warfarin should get a boost next year when an antidote that can reverse the medications' effects in an emergency is expected to enter the market, according to top U.S. heart doctors and investors.  
medscape.com
over 4 years ago
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Warfarin, Sulfonylurea Combo Ups Severe Hypoglycemia Risk

The findings suggest a unique drug-drug interaction between warfarin and glipizide/glimepiride, with the greatest hypoglycemia risk at start of warfarin treatment.  
medscape.com
over 4 years ago
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Three-Year Major Bleeding Risk Same With Watchman or Warfarin

Patients with AF face a similar 3-year bleeding risk if they undergo left atrial appendage closure with this device or stay on long-term warfarin therapy. The CMS cautionary approach is right, two experts say.  
medscape.com
over 4 years ago
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Association between use of warfarin with common sulfonylureas and serious hypoglycemic events: retrospective cohort analysis

Study question Is warfarin use associated with an increased risk of serious hypoglycemic events among older people treated with the sulfonylureas glipizide and glimepiride?  
feeds.bmj.com
over 4 years ago
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Are Patients with Atrial Fibrillation Being Optimally Treated? CME/CE

: New research indicates that primary care physicians underuse stroke and bleeding risk calculators for patients with atrial fibrillation but still aggressively prescribe warfarin.  
medscape.org
over 4 years ago
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Effect of Body Weight on Dose of Vitamin K Antagonists

Should body weight be taken into consideration when prescribing warfarin, especially in obese patients?  
medscape.com
over 4 years ago
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Amid Class 2 Watchman Recall, CMS Proposes Limits on Coverage

While the CMS proposes reimbursement only for afib patients not on warfarin, the FDA warns of blood-leakage risks if the device's hemostasis valve is "tightened with the dilator in place."  
medscape.com
over 4 years ago
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Pharmacogenomic Testing and Warfarin Management

Learn how advances in pharmacogenomic research can improve anticoagulant management.  
medscape.com
over 4 years ago
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Edoxaban vs Warfarin in Patients With AF on Amiodarone

What's the effect of amiodarone on the relative efficacy and safety profile of edoxaban?  
medscape.com
over 4 years ago
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Nil nocere: do no harm reversing warfarin! - St.Emlyn's

reversing warfarin . risks in the emergency department. head injury critical appraisal  
stemlynsblog.org
over 4 years ago
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Nil nocere: do no harm reversing warfarin! - St.Emlyn's

reversing warfarin . risks in the emergency department. head injury critical appraisal  
feedproxy.google.com
over 4 years ago
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Risk of Adverse GI Effects of Dabigatran vs Warfarin in AF

Which agent has greater GI bleeding risk among patients with atrial fibrillation?  
medscape.com
over 4 years ago
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Dancing with the Devil: Taking Dabigatran to the OR - R.E.B.E.L. EM - Emergency Medicine Blog

If you are like me, you are seeing more and more patients on Dabigatran. This drug is touted to be superior to traditional warfarin for reduction of stroke in Afib patients and has had a lot of momentum by many other studies.  
rebelem.com
over 4 years ago
Healio safe image
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Triple therapy has similar outcomes, more bleeding than dual therapy in older patients

Older patients with atrial fibrillation who received triple therapy consisting of aspirin, clopidogrel and warfarin at discharge after PCI for acute MI had a similar risk for major adverse cardiac events at 2 years, but higher rates of major bleeding compared with patients who received aspirin and clopidogrel only. Researchers analyzed 4,959 patients aged 65 years or older from the Acute  
healio.com
over 4 years ago
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Drug interactions with warfarin: what clinicians need to know

Remaining vigilant for interactions between medications is a formidable challenge for several reasons. The science of drug interactions is dauntingly complex and constantly evolving, the patient's medication list is often a moving target with prescription and nonprescription elements, and dozens of new drugs arrive at our pharmacies each year, often with incompletely characterized drug interaction profiles.  
cmaj.ca
over 4 years ago
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Real world effectiveness of warfarin among ischemic stroke patients with atrial fibrillation: observational analysis from Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) study

Objective To examine the association between warfarin treatment and longitudinal outcomes after ischemic stroke in patients with atrial fibrillation in community practice.  
feeds.bmj.com
over 4 years ago
Www.bmj
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Retrospective cohort studies: advantages and disadvantages

Researchers investigated whether differences exist between the sexes in the risk of ischaemic stroke in patients with atrial fibrillation.1 A nationwide retrospective cohort study design was used. Data were taken from the Swedish national discharge register. Participants were 100 802 patients with a first diagnosis of atrial fibrillation between 1 July 2005 and 31 December 2008, with a total follow-up of 139 504 years at risk (median 1.2). Information about drug treatment was taken from the Swedish drug register. Patients were excluded if at baseline they were prescribed warfarin, had mitral stenosis, or had previous valvular surgery. Patients who died less than 14 days from baseline were also excluded.  
feeds.bmj.com
over 4 years ago
Www.bmj
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Sudden onset double vision

An 83 year old woman was admitted to the acute stroke unit with sudden onset double vision that had lasted for three hours. She had a medical history of monoclonal gammopathy of uncertain significance and atrial fibrillation, for which she was not receiving anticoagulation because of an adverse reaction to warfarin. She had no history of transient ischaemic attack or stroke. She had diplopia only when looking through her right. On examination she was unable to adduct her left eye, with nystagmus in her right eye when she attempted to do this. Her neurological examination was otherwise normal. Computed tomography of the head on admission was normal, as was magnetic resonance imaging of the head, which was requested the next day. Figure 1⇓ shows T2 weighted (A) and diffusion weighted (B) sequences at the level of the upper pons.  
feeds.bmj.com
over 4 years ago