What is the advantage of 'block and replace' regime in managing grave's disease patient?

I am now doing a thyroid surgery rotation. This morning we had a tutorial regarding management of patient with grave's disease (hyperthyroid). We were asked about what are the options that available for them. One of the participants highlighted the so called "block and replace regime" in which we are giving patient with carbimazole (block) and thyroxine (replace). The problem is, despite giving carbimazole alone, why do we need to add on thyroxine in managing hyperthyroid patient since this thyroxine might worsen the condition.

Any ideas?

Authored By malek ahmad on Wednesday 31st October 2012

Responses

Aoibhin McGarrity
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Posted almost 8 years ago

I think the main advantage of Block and Replace is that it improves symptoms more quickly. If you give the blocking dose of carbimazole (40mg) it effectively stops the thyroid producing any thyroxine, then you treat as if they are hypothyroid, with an

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saleh Hasan
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Posted almost 8 years ago

Hi!

I'm working as postgraduate doctor within endocrinology as my speciality.
We used block and replace treatment specialy preoperative. This to make patient euthyroid as soon as posiible and prevent TSH to increase which in its turn m

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Dr Luma Khalid
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Posted almost 8 years ago

Block and replace regime is one of the two regimes offered to patients with Graves disease. Although now thyroid ablation with resultant inevitable hypothyroidism is being considered more often. Block and replace is basically a conservative treatment o

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imaobong Uttah
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Posted almost 8 years ago

In Graves disease the thyroid releases excessive thyroid hormone. By blocking it with carbimazole the excessive release of thyroid us prevented and replacing with thyroxine allows sufficient levels of the hormone to prevent hypothyroidism and its effec

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