Cytotoxic Drugs

Hey guys, I'm really struggling with this.

I've read that alkylating agents - a particular type of cytotoxic drug - work through the pairing of alkylguanine and thymine, which leads to the substitution of AT for GC and therefore defective replication.

I'm confused as to why this automatically leads to this substitution?

Authored By Gemma Loach on Wednesday 31st October 2012

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Peter Calvert
·
Medical Student - Lancaster
·
Posted over 7 years ago

Basing this answer on "pharmacology at a glance" textbook and a brief net search!

I can't find anything stating that the alkylating agents always cause a substitution of AT for GC, but it seems they can cause mis-pairing

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Dr Luma Khalid
·
Posted over 7 years ago

I think you have misunderstood what you read. Mechanisms of action of alkylating agents have already been explained in the post above so i am just going to concentrate on the issue you have raised. I see you have already understood the part where the a

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