If low calcium ions level causes "tetany", then does high calcium ions level cause "tetany" also? How so?

From Guyton - Medical Physiology

Low calcium ions level is claimed to cause "tetany" due to the theory stating that calcium ions bind to the exterior surfaces of the sodium channel protein (voltage-gated Na+ channel) molecule and because of their positive charges, they alter the electrical state of the channel protein itself, altering the voltage level required to open the sodium gate, i.e., presence of Ca++ causes an increase in the threshold potential.

What about high calcium level then? Does it cause tetany? If it does, what is the mechanism behind it?

Authored By Rama Raja on Wednesday 28th November 2012

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Raghad Sabbagh
·
Medical Student - Sheffield
·
Posted almost 7 years ago

Hypercalcaemia actually causes muscle weakness, because the high levels of positively changed calcium ions around a neuronal cell shields the negative proteins found on the outside of the cell --> the cell is more positive on the outside --> resulting

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