What causes enlarged platelets?

Hey everyone,

A day before i was having a look at a cbc report which reported enlarged platelets. the patient has not gone through any sort of injury or bleeding disorders. what might be the other reasons of enlarged platelets either pathological or physiological ?

Authored By komal zafar on Wednesday 5th December 2012

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Lize De Klerk
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Posted over 7 years ago

An introductory answer, which I’m sure can be improved upon-:

  1. Large (4 mm diameter) physiologic platelets may indicate increased turnover with shortened marrow release time.

    Q – associated thrombocytopenia/ thrombocytosis?

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Mr Raymond Buick
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Paediatric Surgeon
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Posted over 7 years ago

I presume the previous answer refers to platelets above 4 microns (one millionth of a metre), not as stated 4 mm (millimetres - one thousanth of a metre)

This is not my field but here is a short answer (and a reference)

The platelet pla

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