Hormone sensitive Lipase in Type 2 Diabetes mellitus
My question is regarding the rise of NEFAs as a pathogenic cause of type 2 DM.
In a healthy human hormone sensitive lipase responds to epinephrine, ACTH & glucagon to release glycerol + NEFAs. I thought this enzyme would be the main culprit acting to release glycerol + NEFAs in DM2, however, several papers are saying it markedly reduced! My question is then, if HSL is reduced in type 2 DM/Obese patients, what enzyme is responsible for the lipolysis? Which hormone stimulates it?
I hope someone can shed some light on this.