Lactic Acidosis with Hypokalaemia

Why exactly does this occur. I understand salbutamol increases K+ entry into cells, which therefore increases H+ entry into the blood (K+/H+ exchange) but I thought this would be a metabolic acidosis - why then does lactate build up?

Authored By Ricky Rimmer on Thursday 2nd May 2013


sampath kumar
Posted over 7 years ago

b2-Adrenergic Agents—Epinephrine, Ritodrine, Terbutaline, Salbumatol,
and Dobutamine b-Agonists cause lactic acidosis in several ways.

1) First, b2-adrenergic–mediated stimulation of muscle and hepatic phosphorylase and inhibition of glycog