Increased GFR or decreased GFR in DM causes diabetic nephropathy?

Hi everyone,

I am a little confused about the pathogenesis of diabetic nephropathy in DM. Is it...

...hyperglycaemia inducing vasodilation in the renal arteries ---> increased GFR ---> damage to the glomerulus ---> eventually, end stage renal disease?

OR

...hyaline arterial stenosis of renal arteries ---> decreased GFR ---> nephrotic syndrome ---> end stage renal disease?

OR

...hyperglycaemia inducing matrix proliferation in the glomerulus ---> decreased GFR ---> damage to the glomerulus ---> end stage renal disease?

OR

...none of the above?

Would appreciate it if anyone who can shed some light! Thanks!

Authored By Syaza Faizul on Sunday 8th December 2013

Responses

sampath kumar
·
Posted over 6 years ago

Renal Complications of Diabetes Mellitus

Like other microvascular complications, the pathogenesis of diabetic nephropathy is related to chronic hyperglycemia. The mechanisms by which chronic hyperglycemia leads to ESRD, though incompletely defi

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Ahmed Iraqi
·
Posted over 6 years ago

The earliest detectable change in the course of diabetic nephropathy is a thickening in the glomerulus. At this stage, the kidney may leak more serum albumin (plasma protein) than normal in the urine (albuminuria), and this can be detected by sensitive

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