Increased GFR or decreased GFR in DM causes diabetic nephropathy?
Hi everyone,
I am a little confused about the pathogenesis of diabetic nephropathy in DM. Is it...
...hyperglycaemia inducing vasodilation in the renal arteries ---> increased GFR ---> damage to the glomerulus ---> eventually, end stage renal disease?
OR
...hyaline arterial stenosis of renal arteries ---> decreased GFR ---> nephrotic syndrome ---> end stage renal disease?
OR
...hyperglycaemia inducing matrix proliferation in the glomerulus ---> decreased GFR ---> damage to the glomerulus ---> end stage renal disease?
OR
...none of the above?
Would appreciate it if anyone who can shed some light! Thanks!